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DEK

  • Official Full Name

    DEK oncogene

  • Overview

    This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    DEK; DEK oncogene; DEK oncogene (DNA binding); protein DEK; D6S231E; DEK gene; DEK oncogene DNA binding; DEK_HUMAN; DNA binding; OTTHUMP00000039357; OTTHUMP00000016078; OTTHUMP00000221544; OTTHUMP00000221545;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • MYC
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DEK-2529H Recombinant Human DEK Protein, GST-tagged Wheat Germ GST
Human DEK-433H Recombinant Human DEK Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DEK-2046H Recombinant Human DEK, GST-tagged E.coli GST
Human DEK-6980HCL Recombinant Human DEK 293 Cell Lysate HEK293 N/A
Human DEK-1385H Recombinant Human DEK protein, His&Myc-tagged E.coli His&Myc 309-375aa(S375SLEH)
Human DEK-748H-B Recombinant Human DEK Protein Pre-coupled Magnetic Beads HEK293
Human DEK-5902H Recombinant Human DEK protein, His&Myc-tagged Insect Cell His&Myc 2-375aa
Human DEK-1090HFL Recombinant Full Length Human DEK Protein, C-Flag-tagged Mammalian cells Flag
Human DEK-748H Recombinant Human DEK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DEK-2457HF Recombinant Full Length Human DEK Protein, GST-tagged In Vitro Cell Free System GST 375 amino acids
Mouse DEK-180M Recombinant Mouse DEK protein, His-tagged Insect Cell His 1-380aa
Mouse Dek-447M Recombinant Mouse Dek Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat DEK-1845R Recombinant Rat DEK Protein Mammalian Cell His
Rat DEK-1503R-B Recombinant Rat DEK Protein Pre-coupled Magnetic Beads HEK293
Rat DEK-1503R Recombinant Rat DEK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DEK-1241R Recombinant Rhesus monkey DEK Protein, His-tagged Mammalian Cell His
Rhesus Macaque DEK-1066R-B Recombinant Rhesus Macaque DEK Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DEK-1066R Recombinant Rhesus Macaque DEK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DEK-4273Z Recombinant Zebrafish DEK Mammalian Cell His
Chicken DEK-1932C Recombinant Chicken DEK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DEK Related Articles

DEK involved in several pathways and played different roles in them. We selected most pathways DEK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DEK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DEK has several biochemical functions, for example, DNA binding, histone binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEK itself. We selected most functions DEK had, and list some proteins which have the same functions with DEK. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHOXC12;SSBP3B;ELK4;HOXC11A;UBP1;ASH2L;THAP5;TSG101;FOSL1A
histone bindingTONSL;RNF20;SIRT1;ELP2;COPRS;NCL;Ctsl;NPM2;BRD7
poly(A) RNA bindingHIST1H4L;ZFP622;MRPL41;U2SURP;HNRNPH3;ARF1;EEF2;RBM4B;D19BWG1357E

DEK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEK here. Most of them are supplied by our site. Hope this information will be useful for your research of DEK.

DAXX; CSNK2A1; UPF1; q7cit1_yerpe; NOP56; ESR1; DBP; CSNK2A2; RPL10; HIST2H4B; HIST1H3D; NR5A1; Rpl35; MMGT1; HDAC2

Patel, RM; Walters, LL; et al. DEK expression in Merkel cell carcinoma and small cell carcinoma. JOURNAL OF CUTANEOUS PATHOLOGY 39:753-757(2012).
Kostianets, O; Shyian, M; et al. Serological Analysis of SEREX-Defined Medullary Breast Carcinoma-Associated Antigens. CANCER INVESTIGATION 30:519-527(2012).
  • Q&As
  • Reviews

Q&As (5)

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What are the current diagnostic methods for assessing DEK protein levels in clinical samples? 04/01/2022

Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry are commonly used to measure DEK protein levels in clinical samples from cancer and autoimmune disease patients.

How does DEK protein contribute to the pathogenesis of autoimmune diseases? 07/23/2021

DEK protein has been shown to play a role in aberrant immune responses, leading to the development of autoimmune diseases such as lupus and rheumatoid arthritis.

How does DEK protein interact with other cellular proteins in cancer and autoimmune diseases? 01/26/2021

DEK protein has been shown to interact with various cellular proteins, modulating signaling pathways and gene expression patterns associated with cancer and autoimmune diseases.

Are there any specific genetic mutations associated with DEK protein dysregulation in cancer? 07/12/2019

Mutations in the DEK gene and its regulatory regions have been identified in certain cancers, contributing to its aberrant expression and oncogenic potential.

Can DEK protein levels in patient samples predict treatment response in cancer therapy? 10/15/2017

Studies have suggested that DEK protein levels in patient samples may serve as predictive biomarkers for treatment response and resistance in cancer therapy.

Customer Reviews (3)

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Reviews
08/27/2021

    This collaboration may extend beyond the purchase of the DEK protein, potentially leading to additional support, joint research projects, or access to expertise in the field.

    12/20/2019

      This may include providing detailed protocols, troubleshooting advice, and suggestions for experimental design.

      08/13/2016

        The manufacturer can provide researchers with high-quality DEK protein, ensuring it is properly purified, characterized, and quality-controlled.

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