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DERL2

  • Official Full Name

    Der1-like domain family, member 2

  • Overview

    Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the;homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER (Oda et al., 2006;(PubMed 16449189)).
  • Synonyms

    DERL2; Der1-like domain family, member 2; derlin-2; CGI 101; derlin 2; F LAN 1; F LANa; FLANa; Carcinoma related; Degradation in endoplasmic reticulum protein 2; DER 2; Der1 like domain family member 2; DER2; DERL 2; Derlin2; DERtrin 2; DERtrin2; DERtrin-2; OTTHUMP00000128204; der1-like protein 2; F-LANa; CGI-101; F-LAN-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Dictyostelium discoideum (Slime mold)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DERL2-984H Recombinant Human DERL2 Mammalian Cell His
Human DERL2-11941H Recombinant Human DERL2, His-tagged E.coli His 1-70a.a.
Human DERL2-6970HCL Recombinant Human DERL2 293 Cell Lysate HEK293 N/A
Human DERL2-2389H Recombinant Human DERL2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DERL2-2791H Recombinant Human DERL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DERL2-2791H-B Recombinant Human DERL2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Derl2-584M Recombinant Mouse Derl2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Dictyostelium discoideum (Slime mold) RFL31419DF Recombinant Full Length Dictyostelium Discoideum Probable Derlin-2 Homolog(Derl2) Protein, His-Tagged E.coli expression system His Full Length (1-254)
Homo sapiens (Human) RFL32737HF Recombinant Full Length Human Derlin-2(Derl2) Protein, His-Tagged E.coli expression system His Full Length (1-239)
Mus musculus (Mouse) RFL24828MF Recombinant Full Length Mouse Derlin-2(Derl2) Protein, His-Tagged E.coli expression system His Full Length (1-239)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL33857PF Recombinant Full Length Pongo Abelii Derlin-2(Derl2) Protein, His-Tagged E.coli expression system His Full Length (1-239)
Rhesus Macaque DERL2-1245R Recombinant Rhesus monkey DERL2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DERL2-1070R Recombinant Rhesus Macaque DERL2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DERL2-1070R-B Recombinant Rhesus Macaque DERL2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DERL2-3002Z Recombinant Zebrafish DERL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DERL2 involved in several pathways and played different roles in them. We selected most pathways DERL2 participated on our site, such as Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with DERL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationANKRD28;NANP;CTSZ;MIA3;ST8SIA2;TRAPPC6BL;ALG2;TRAPPC1;MPDU1
Calnexin/calreticulin cycleMAN1B1;OS9;DERL2
DiseaseFDX1L;GPC5;FKBP1A;PRELP;KREMEN1;NUPL2;RBP4;EEF2;CTDP1
Diseases of signal transductionCTBP1;DERL2;OS9;RBP4;RNF43;OPN1MW;OPN1LW;KREMEN2;HEYL
ER Quality Control Compartment (ERQC)OS9;MAN1B1;DERL2
Hedgehog ligand biogenesisOS9;SCUBE2;GPC5A;HHAT;DISP2;DERL2;NOTUM1A;NOTUM
Hh mutants abrogate ligand secretionDERL2;OS9
Hh mutants that dont undergo autocatalytic processing are degraded by ERADOS9;DERL2

DERL2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DERL2 itself. We selected most functions DERL2 had, and list some proteins which have the same functions with DERL2. You can find most of the proteins on our site.

Function Related Protein
protein bindingZNF274;PDIA2;VPS54;PMM2;CD69;NPHP4;ZNF34;EIF4EBP2;RFWD2

DERL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DERL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DERL2.

KRTAP10-7; KRTAP10-8; Dlg4; Kcnk1; Smn1; REEP5; TMEM63B; Kctd5; MASTL; Hspa14; FZD1

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