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DGCR8

  • Official Full Name

    DGCR8 microprocessor complex subunit

  • Overview

    This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
  • Synonyms

    DGCR8; DGCR8 microprocessor complex subunit; Gy1; pasha; DGCRK6; C22orf12; microprocessor complex subunit DGCR8; DiGeorge syndrome critical region 8; DiGeorge syndrome critical region gene 8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DGCR8-2567H Recombinant Human DGCR8 Protein, GST-tagged Wheat Germ GST
Human DGCR8-6962HCL Recombinant Human DGCR8 293 Cell Lysate HEK293 N/A
Human DGCR8-2495HF Recombinant Full Length Human DGCR8 Protein, GST-tagged In Vitro Cell Free System GST 773 amino acids
Human DGCR8-1141HFL Recombinant Full Length Human DGCR8 Protein, C-Flag-tagged Mammalian cells Flag
Human DGCR8-750H Recombinant Human DGCR8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DGCR8-750H-B Recombinant Human DGCR8 Protein Pre-coupled Magnetic Beads HEK293
Mouse DGCR8-4541M Recombinant Mouse DGCR8 Protein Mammalian Cell His
Mouse DGCR8-2348M Recombinant Mouse DGCR8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dgcr8-2533M Recombinant Mouse Dgcr8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DGCR8-2348M-B Recombinant Mouse DGCR8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DGCR8-1252R Recombinant Rhesus monkey DGCR8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DGCR8-1077R Recombinant Rhesus Macaque DGCR8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DGCR8-1077R-B Recombinant Rhesus Macaque DGCR8 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DGCR8-6587Z Recombinant Zebrafish DGCR8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DGCR8 involved in several pathways and played different roles in them. We selected most pathways DGCR8 participated on our site, such as Direct p53 effectors, Gene Expression, Gene Silencing by RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGCR8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Direct p53 effectorsBNIP3L;DDX5;CD82;RNF144B;AIFM2;PLK3;DUSP1;GDF15;NDRG1
Gene ExpressionHNRNPH1L;ZIM2;ADAT3;HNRNPL;DDX4;FAM36A;SCO1;ZNF45;RXRBB
Gene Silencing by RNADPY19L2;TSNAX;TDRD1;DGCR8;PLD6;ASZ1;TSN;MYBL1;FKBP6
MicroRNA (miRNA) biogenesisTARBP2;BARHL1;DGCR8

DGCR8 has several biochemical functions, for example, double-stranded RNA binding, heme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DGCR8 itself. We selected most functions DGCR8 had, and list some proteins which have the same functions with DGCR8. You can find most of the proteins on our site.

Function Related Protein
double-stranded RNA bindingOAS1A;OAS1B;ILF2;IFIH1;OAS2;DDX58;PRKRIP1;MBNL1;HMGB1
heme bindingCYP1C2;CYP7B1;CYP2AA1;CYP2AA9;GUCY1B3;CYP26C1;EPX;CYP46A1.1;CYP2D6
metal ion bindingATP2B1B;ZNF230;TRIM35;TGFBR2;NME2;PARP12;ZEB2;PAN3;PIR
primary miRNA bindingDGCR8;SRF
protein bindingADIPOQ;CPSF2;F2RL1;FZD8;MYCN;UPF3B;TIMELESS;GGA1;EFNA4
protein homodimerization activityMECOM;NR6A1B;STK10;PTS;RAP1GAP;ATF3;ERP29;NLGN4X;TBX15
contributes_to ribonuclease III activity

DGCR8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGCR8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DGCR8.

DROSHA; SRPK1; MEOX2; DDX17; EEF1D; HNRNPUL1; KIF15

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