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DGKA

  • Official Full Name

    diacylglycerol kinase, alpha 80kDa

  • Overview

    The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
  • Synonyms

    DGKA; diacylglycerol kinase, alpha 80kDa; DAGK, DAGK1, diacylglycerol kinase, alpha (80kD); diacylglycerol kinase alpha; DGK alpha; DAG kinase alpha; diglyceride kinase alpha; 80 kDa diacylglycerol kinase; DAGK; DAGK1; DGK-alpha; MGC12821; MGC42356;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Bacillus subtilis (strain 168)
  • Human
  • Mouse
  • Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
  • Rat
  • Synechocystis sp. (strain PCC 6803 / Kazusa)
  • E. coli or Yeast
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DGKA-181H Active Recombinant Human DGKA protein, GST-tagged Insect Cell GST
Human DGKA-2569H Recombinant Human DGKA Protein, GST-tagged Wheat Germ GST
Human DGKA-26771TH Recombinant Human DGKA Wheat Germ N/A 735 amino acids
Human DGKA-6960HCL Recombinant Human DGKA 293 Cell Lysate HEK293 N/A
Human DGKA-6961HCL Recombinant Human DGKA 293 Cell Lysate HEK293 N/A
Human DGKA-751H Recombinant Human DGKA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DGKA-358H Recombinant Human DGKA Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human DGKA-2096H Recombinant Human DGKA Protein (1-735 aa), His-tagged E.coli His 1-735 aa
Human DGKA-1056H Recombinant Human DGKA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DGKA-4712H Recombinant Human DGKA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DGKA-125HF Recombinant Full Length Human DGKA Protein In Vitro Cell Free System 735 amino acids
Human DGKA-627HFL Recombinant Full Length Human DGKA Protein, C-Flag-tagged Mammalian cells Flag
Human DGKA-2496HF Recombinant Full Length Human DGKA Protein, GST-tagged In Vitro Cell Free System GST 735 amino acids
Human DGKA-751H-B Recombinant Human DGKA Protein Pre-coupled Magnetic Beads HEK293
Mouse DGKA-4542M Recombinant Mouse DGKA Protein Mammalian Cell His
Mouse DGKA-2349M-B Recombinant Mouse DGKA Protein Pre-coupled Magnetic Beads HEK293
Mouse DGKA-2349M Recombinant Mouse DGKA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dgka-2534M Recombinant Mouse Dgka Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Dgka-677M Recombinant Mouse Dgka Protein, His-tagged E.coli His His305~Arg531
Rat DGKA-1854R Recombinant Rat DGKA Protein Mammalian Cell His
Rat Dgka-11R Recombinant Active Rat Dgka Protein, His-tagged Insect Cell His
Rat DGKA-1512R-B Recombinant Rat DGKA Protein Pre-coupled Magnetic Beads HEK293
Rat Dgka-678R Recombinant Rat Dgka Protein, His-tagged E.coli His Ala312~Glu557
Rat DGKA-1512R Recombinant Rat DGKA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bacillus subtilis DGKA-1044B Recombinant Bacillus subtilis DGKA protein, His-tagged E. coli or Yeast His
Bacillus subtilis (strain 168) RFL4857BF Recombinant Full Length Bacillus Subtilis Undecaprenol Kinase(Dgka) Protein, His-Tagged E.coli expression system His Full Length (1-123)
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) RFL31584PF Recombinant Full Length Pseudomonas Aeruginosa Diacylglycerol Kinase(Dgka) Protein, His-Tagged E.coli expression system His Full Length (1-123)
Synechocystis sp. (strain PCC 6803 / Kazusa) RFL17595SF Recombinant Full Length Synechocystis Sp. Probable Diacylglycerol Kinase(Dgka) Protein, His-Tagged E.coli expression system His Full Length (1-175)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DGKA Related Articles
  • DGKA Related Research Area

DGKA involved in several pathways and played different roles in them. We selected most pathways DGKA participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Choline metabolism in cancer, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcineurin-regulated NFAT-dependent transcription in lymphocytesJUNB;EGR3;EGR1;DGKA;CSF2;BATF3;CTLA4;EGR4;IKZF1
Choline metabolism in cancerPIK3CD;EIF4EBP1;MTOR;MAP2K2;RAC1;DGKA;PDPK1;GPCPD1;SLC22A5
Effects of PIP2 hydrolysisABHD12;TRPC3;DGKA;PRKCHB;MGLL;DGKQ;TRPC7;TAE1;TRPC6A
G alpha (q) signalling eventsANXA1A;GPRC6A;TRPC6A;NPFF;NMBB;NMU;UTS2;NPS;DGKG
GPCR downstream signalingCNR1;NMB;ADM2A;PROK1;PIK3R6;SCT;OPN1MW2;TAE1;SSTR1
Gastrin-CREB signalling pathway via PKC and MAPKFFAR3;OXTRL;FPR-RS3;PRKCHB;GPR132B;LTB4R;EDN2;OPN4;TAC3
Glycerolipid metabolismAGPAT9;ALDH1B1;AKR1B10;GPAM;PNPLA3;GLA;PNLIPRP3;GLYCTK;DAK
Glycerophospholipid metabolismCDIPT;GNPAT;PLA2G12B;CEPT1B;AGPAT9;ETNPPL;CDS2;PPAP2A;AGPAT2

DGKA has several biochemical functions, for example, ATP binding, calcium ion binding, diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKA itself. We selected most functions DGKA had, and list some proteins which have the same functions with DGKA. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYO7B;CDC42BPB;PANK1A;AK7B;DNAH14;ALDH18A1;SNRKA;KIF26A;KIF11
calcium ion bindingKCNIP4;PLA2G12A;MYL13;MASP1;NUCB1;FBN2B;PCDH1G32;VSNL1A;MMP15
diacylglycerol kinase activityDGKD;DGKZ;AGK;DGKAA;DGKB;DGKQ;TAE1;DGKA;DGKE
phospholipid bindingDefa4;FABP1;APOA1;CPS1;F10;APOEA;MYOF;PACSIN1;SYT14

DGKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKA here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKA.

SRC; IL21; adhB

Li, DF; Pye, VE; et al. Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:104-122(2015).
Comba, S; Sabatini, M; et al. Engineering a Streptomyces coelicolor biosynthesis pathway into Escherichia coli for high yield triglyceride production. BIOTECHNOLOGY FOR BIOFUELS 7:-(2014).
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