DGKA
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Official Full Name
diacylglycerol kinase, alpha 80kDa
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Overview
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. -
Synonyms
DGKA; diacylglycerol kinase, alpha 80kDa; DAGK, DAGK1, diacylglycerol kinase, alpha (80kD); diacylglycerol kinase alpha; DGK alpha; DAG kinase alpha; diglyceride kinase alpha; 80 kDa diacylglycerol kinase; DAGK; DAGK1; DGK-alpha; MGC12821; MGC42356;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Bacillus subtilis (strain 168)
- Human
- Mouse
- Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
- Rat
- Synechocystis sp. (strain PCC 6803 / Kazusa)
- E. coli or Yeast
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DGKA Related Articles
- DGKA Related Research Area
DGKA involved in several pathways and played different roles in them. We selected most pathways DGKA participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Choline metabolism in cancer, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes | JUNB;EGR3;EGR1;DGKA;CSF2;BATF3;CTLA4;EGR4;IKZF1 |
Choline metabolism in cancer | PIK3CD;EIF4EBP1;MTOR;MAP2K2;RAC1;DGKA;PDPK1;GPCPD1;SLC22A5 |
Effects of PIP2 hydrolysis | ABHD12;TRPC3;DGKA;PRKCHB;MGLL;DGKQ;TRPC7;TAE1;TRPC6A |
G alpha (q) signalling events | ANXA1A;GPRC6A;TRPC6A;NPFF;NMBB;NMU;UTS2;NPS;DGKG |
GPCR downstream signaling | CNR1;NMB;ADM2A;PROK1;PIK3R6;SCT;OPN1MW2;TAE1;SSTR1 |
Gastrin-CREB signalling pathway via PKC and MAPK | FFAR3;OXTRL;FPR-RS3;PRKCHB;GPR132B;LTB4R;EDN2;OPN4;TAC3 |
Glycerolipid metabolism | AGPAT9;ALDH1B1;AKR1B10;GPAM;PNPLA3;GLA;PNLIPRP3;GLYCTK;DAK |
Glycerophospholipid metabolism | CDIPT;GNPAT;PLA2G12B;CEPT1B;AGPAT9;ETNPPL;CDS2;PPAP2A;AGPAT2 |
DGKA has several biochemical functions, for example, ATP binding, calcium ion binding, diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKA itself. We selected most functions DGKA had, and list some proteins which have the same functions with DGKA. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | MYO7B;CDC42BPB;PANK1A;AK7B;DNAH14;ALDH18A1;SNRKA;KIF26A;KIF11 |
calcium ion binding | KCNIP4;PLA2G12A;MYL13;MASP1;NUCB1;FBN2B;PCDH1G32;VSNL1A;MMP15 |
diacylglycerol kinase activity | DGKD;DGKZ;AGK;DGKAA;DGKB;DGKQ;TAE1;DGKA;DGKE |
phospholipid binding | Defa4;FABP1;APOA1;CPS1;F10;APOEA;MYOF;PACSIN1;SYT14 |
DGKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKA here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKA.
SRC; IL21; adhB
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