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DGKG

  • Official Full Name

    diacylglycerol kinase, gamma 90kDa

  • Overview

    This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    DGKG; diacylglycerol kinase, gamma 90kDa; DAGK3, diacylglycerol kinase, gamma (90kD); diacylglycerol kinase gamma; DAG kinase gamma; diglyceride kinase gamma; diacylglyerol kinase gamma; DAGK3; DGK-GAMMA; MGC104993; MGC133330;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DGKG-1361H Recombinant Human DGKG protein, His & T7-tagged E.coli His/T7 Ile451~Gln698 (Accession # P49619)
Human DGKG-2574H Recombinant Human DGKG Protein, GST-tagged Wheat Germ GST
Human DGKG-6955HCL Recombinant Human DGKG 293 Cell Lysate HEK293 N/A
Human DGKG-6954HCL Recombinant Human DGKG 293 Cell Lysate HEK293 N/A
Human DGKG-6956HCL Recombinant Human DGKG 293 Cell Lysate HEK293 N/A
Human DGKG-01H Recombinant Human DGKG Protein, His-tagged Insect Cell His
Human DGKG-15H Recombinant Active Human DGKG Protein, His-tagged Insect Cell His
Human DGKG-454H Recombinant Human DGKG Protein (1-255 aa), His-SUMO-tagged E.coli His/SUMO 1-255 aa
Human DGKG-12H Recombinant Active Human DGKG Protein, GST-tagged Insect Cell GST
Human DGKG-2499HF Recombinant Full Length Human DGKG Protein, GST-tagged In Vitro Cell Free System GST 766 amino acids
Human DGKG-13H Recombinant Active Human DGKG Protein, His-tagged Insect Cell His
Human DGKG-14H Recombinant Active Human DGKG Protein, His-tagged Insect Cell His
Human DGKG-1918H Recombinant Human DGKG Protein (Ile451-Gln698), N-His tagged E.coli N-His Ile451-Gln698
Mouse Dgkg-1362M Recombinant Mouse Dgkg protein, His & T7-tagged E.coli His/T7 Asp346~Met576 (Accession # Q91WG7)
Mouse Dgkg-458M Recombinant Mouse Dgkg Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat DGKG-1856R Recombinant Rat DGKG Protein Mammalian Cell His
Rat Dgkg-1363R Recombinant Rat Dgkg protein, His & T7-tagged E.coli His/T7 Ile287~Arg524 (Accession # P49620)
Rat DGKG-1514R Recombinant Rat DGKG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DGKG-1514R-B Recombinant Rat DGKG Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DGKG Related Articles
  • DGKG Related Research Area

DGKG involved in several pathways and played different roles in them. We selected most pathways DGKG participated on our site, such as Choline metabolism in cancer, Effects of PIP2 hydrolysis, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Choline metabolism in cancerRHEB;FOS;CHKB;SLC5A7;DGKD;SP1;PPAP2A;PLA2G4B;PCYT1A
Effects of PIP2 hydrolysisMGLL;DGKA;TRPC3;ABHD12;PRKCHB;ABHD6B;TAE1;TRPC7;RASGRP2
G alpha (q) signalling eventsMLN;DGKA;EDN2;TAC2;TAC3;RGS21;LPAR5A;ANXA1B;KISS1
GPCR downstream signalingGPR18;HCAR1-2;TAS2R7;CNR2;ARHGEF18A;QRFP;TRIO;PIK3R6;CHRM3
Gastrin-CREB signalling pathway via PKC and MAPKGRP;TRPC3;TRPC7;LPAR2B;RASGRP2;LPAR1;FPR-RS4;TRH;LTB4R
Glycerolipid metabolismDGKA;LIPC;AKR1B1L;Akr1b3;MOGAT1;LPIN2;GK2;TAE1;DGAT1
Glycerophospholipid metabolismPLA2G1B;PLA2G16;DGKG;PLA2G4A;ETNPPL;DGKD;AGPAT5;CDS1;GNPAT
HemostasisSTXBP3A;MFN1;ZFPM2A;LOC100514666;KIF4;ATP2B1B;GNA13B;SH2B3;BSG

DGKG has several biochemical functions, for example, ATP binding, calcium ion binding, diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKG itself. We selected most functions DGKG had, and list some proteins which have the same functions with DGKG. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSMC5;MYO7B;KIF7;FARS2;HIPK1;MAT2AB;ATP12A;LARS2;PRKD1
calcium ion bindingSLIT2;UMOD;EYS;PCDH1G2;S100A4;PPEF1;BRAF;PLA2G2E;NOTCH2
diacylglycerol kinase activityDGKB;DGKZ;DGKG;DGKQ;DGKE;DGKAA;DGKA;AGK;TAE1

DGKG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKG here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKG.

ALB; ARRB1

Lisowski, P; Wieczorek, M; et al. Effects of Chronic Stress on Prefrontal Cortex Transcriptome in Mice Displaying Different Genetic Backgrounds. JOURNAL OF MOLECULAR NEUROSCIENCE 50:33-57(2013).
Vahtola, E; Storvik, M; et al. Effects of Levosimendan on Cardiac Gene Expression Profile and Post-Infarct Cardiac Remodelling in Diabetic Goto-Kakizaki Rats. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 109:387-397(2011).
  • Q&As
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