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DGKQ

  • Official Full Name

    diacylglycerol kinase, theta 110kDa

  • Overview

    The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
  • Synonyms

    DGKQ; diacylglycerol kinase, theta 110kDa; DAGK4, diacylglycerol kinase, theta (110kD); diacylglycerol kinase theta; DAGK; DAGK7; DGK-theta; DAG kinase theta; diglyceride kinase theta; DAGK4;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DGKQ-522H Recombinant Human DGKQ Mammalian Cell His
Human DGKQ-11959H Recombinant Human DGKQ, His-tagged E.coli His 595-942a.a.
Human DGKQ-2796H Recombinant Human DGKQ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DGKQ-1336H Recombinant Human DGKQ Protein, His-tagged E.coli N-His Pro584-Ala721
Human DGKQ-2796H-B Recombinant Human DGKQ Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DGKQ Related Articles
  • DGKQ Related Research Area

DGKQ involved in several pathways and played different roles in them. We selected most pathways DGKQ participated on our site, such as Choline metabolism in cancer, Effects of PIP2 hydrolysis, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Choline metabolism in cancerRAC1;EGF;MAPK3;PLA2G4A;WAS;PIK3R5;MAP2K1;PRKCG;DGKG
Effects of PIP2 hydrolysisRASGRP2;MGLL;DGKQ;DGKG;ABHD12;ABHD6B;TRPC7;PRKCHB;DGKB
G alpha (q) signalling eventsTRPC3;FPR-RS4;PROK1;NPSR1;GPR132B;AGTR1;ABHD12;EDNRB;ANXA1B
GPCR downstream signalingCNR1;GHRH;ABHD6B;OR7D2;GPR55A;PROKR1A;RXFP2;ANXA1A;PENK
Gastrin-CREB signalling pathway via PKC and MAPKGCGB;NMUR1;QRFP;GPR4;CASR;FPR-RS6;TRPC7;MLN;UTS2
Glycerolipid metabolismLPIN2;AGPAT9L;ALDH9A1B;LPIN1;ALDH2;PNLIP;GLA;Akr1b3;AKR1B1L
Glycerophospholipid metabolismPLA2G6;PNPLA7;CHATA;PMT;LPIN1;PCYT1BB;GPD2;ETNK2;ACHE
HemostasisPRTN3;CAP1;KIF4A;SLC3A2B;ZFPM2A;TAE1;AKAP10;MAFG;AMICA1

DGKQ has several biochemical functions, for example, ATP binding, activating transcription factor binding, diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKQ itself. We selected most functions DGKQ had, and list some proteins which have the same functions with DGKQ. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPIK3CD;RFK;SYN3;UBE2D1;PHKG1A;STRADA;MYLK;ADCK1;EPHA4A
activating transcription factor bindingPPARG;RELA;HDAC7A;ZFP516;HDAC4;HDAC7;ATOH8;HDAC1;MEF2A
diacylglycerol kinase activityDGKE;DGKAA;DGKQ;DGKA;TAE1;DGKD;DGKG;DGKB;AGK
kinase bindingPARK2;SLC2A1;TRIP6;CTNNB1;CEBPA;RB1;PER3;STUB1;JAKMIP3
metal ion bindingB4GALT3;PRDM15;ZNF750;CYP21A1;ZFP346;TRIM55A;POLM;NCS1A;ZNF711
phospholipase bindingCALM3;Pla2r1;PDPK1;NEFL;CALM1;CALM2;PTPN11;PRKCZ;SERPINB1A
protein bindingHEYL;PDLIM5;PAM;TSPO;AZIN2;CLEC4G;CASC3;EGR1;TRIM69

DGKQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKQ here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKQ.

pi3p

Nalls, MA; Pankratz, N; et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. NATURE GENETICS 46:989-+(2014).
Lessard, CJ; Li, H; et al. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome. NATURE GENETICS 45:1284-+(2013).
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