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DGKZ

  • Official Full Name

    diacylglycerol kinase, zeta

  • Overview

    The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified.
  • Synonyms

    DGKZ; diacylglycerol kinase, zeta; diacylglycerol kinase, zeta 104kDa; diacylglycerol kinase zeta; DAGK5; DAGK6; DGK ZETA; hDGKzeta; DAG kinase zeta; diglyceride kinase zeta; DGK-ZETA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DGKZ-2577H Recombinant Human DGKZ Protein, GST-tagged Wheat Germ GST
Human DGKZ-11960H Recombinant Human DGKZ, His-tagged E.coli His 296-600a.a.
Human DGKZ-26682TH Recombinant Human DGKZ, His-tagged E.coli His
Human DGKZ-6953HCL Recombinant Human DGKZ 293 Cell Lysate HEK293 N/A
Human DGKZ-19H Recombinant Active Human DGKZ Protein, His-tagged Insect Cell His
Human DGKZ-45H Recombinant Human DGKZ Protein, Flag-tagged HEK293 Flag
Human DGKZ-752H Recombinant Human DGKZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DGKZ-752H-B Recombinant Human DGKZ Protein Pre-coupled Magnetic Beads HEK293
Human DGKZ-3861H Recombinant Human DGKZ protein, His-tagged E.coli His 297-601 aa
Human DGKZ-3295H Recombinant Human DGKZ Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DGKZ-542HFL Recombinant Full Length Human DGKZ Protein, C-Flag-tagged Mammalian cells Flag
Human DGKZ-2508HF Recombinant Full Length Human DGKZ Protein, GST-tagged In Vitro Cell Free System GST 929 amino acids
Human DGKZ-2246H Recombinant Human DGKZ Protein (Val506-Ala743), N-His tagged E.coli N-His Val506-Ala743
Mouse Dgkz-1364M Recombinant Mouse Dgkz protein, His & T7-tagged E.coli His/T7 Tyr657~Val879 (Accession # Q80UP3)
Mouse Dgkz-260M Recombinant Mouse Dgkz Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat DGKZ-1857R Recombinant Rat DGKZ Protein Mammalian Cell His
Rat DGKZ-1515R-B Recombinant Rat DGKZ Protein Pre-coupled Magnetic Beads HEK293
Rat DGKZ-1515R Recombinant Rat DGKZ Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken DGKZ-2856C Recombinant Chicken DGKZ Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DGKZ Related Articles
  • DGKZ Related Research Area

DGKZ involved in several pathways and played different roles in them. We selected most pathways DGKZ participated on our site, such as Glycerolipid metabolism, Glycerophospholipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycerolipid metabolismDGKAA;ALDH2.1;GLYCTK;ALDH9A1;MOGAT1;LIPG;AKR1B1L;ALDH7A1;PPAP2D
Glycerophospholipid metabolismCEPT1B;DGKZ;EPT1;AGPAT3;MBOAT2B;PLA2G5;PLA2G1B;PLA2G3;CHAT
Metabolic pathwaysG6PC;PPAP2A;ST6GALNAC1;GATC;CECR1A;CYP4A10;ITPKC;CKBB;AKR1B1
Phosphatidylinositol signaling systemPRKCA;CALML3;PIP4K2B;OCRL;PLCB4;PIK3C2B;PLCD1A;IPMKB;MTMR2
Phospholipase D signaling pathwayCXCR1;INS2;GRM1;MAPK3;PLCB2;PIK3R5;AKT2;LPAR4;PLA2G4F
Choline metabolism in cancerPIK3R2;PDPK1;RPS6KB1;WASL;CHKB;PLA2G4A;Pdgfa&Pdgfb;RAF1;SLC22A5

DGKZ has several biochemical functions, for example, ATP binding, diacylglycerol kinase activity, enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKZ itself. We selected most functions DGKZ had, and list some proteins which have the same functions with DGKZ. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRPF4BA;RBKS;NEK3;DDX3;TBCK;RFK;CTPS2;CSNK1G3;TIE1
diacylglycerol kinase activityTAE1;DGKD;DGKB;DGKZ;DGKAA;DGKG;DGKQ;AGK;DGKE
enzyme inhibitor activitySCG5;ATPIF1;APOV1;WFIKKN1;TXNIP;PRPSAP1;TAE1;APBA3;FRY
lipid kinase activityPIK3C2B;TAE1;DGKZ
metal ion bindingDMRT2;KLF2A;NANOS1;ZFP583;POLK;TRIM35-21;ZNF592;KDM6B;TAX1BP1
protein C-terminus bindingHPCAL4;YEATS4;RAD51;CEP135;VPS36;MRE11A;XRCC5;CAV3;TFCP2
protein bindingITGA3;CAV1;PDXP;Abcb1b;MED23;BRCC3;NUP50;YAP1;DAB2

DGKZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKZ here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKZ.

SAT1; MAPK6; GRINL1A; q8ckj5_yerpe; tnp_8; npm_alk; ARRB2; ARRB1; CBX8

Wang, LCS; Lo, A; et al. Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity. CANCER IMMUNOLOGY RESEARCH 2:154-166(2014).
Wheeler, ML; Dong, MB; et al. Diacylglycerol Kinase zeta Limits B Cell Antigen Receptor-Dependent Activation of ERK Signaling to Inhibit Early Antibody Responses. SCIENCE SIGNALING 6:-(2013).
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