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DGUOK

  • Official Full Name

    deoxyguanosine kinase

  • Overview

    In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two;deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein;encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In;addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of;lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative;splice variants encoding different protein isoforms have been described for this gene.
  • Synonyms

    DGUOK; deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; Deoxyguanosine kinase mitochondrial; OTTHUMP00000160251; OTTHUMP00000160252; mitochondrial deoxyguanosine kinase; MTDPS3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DGUOK-2579H Recombinant Human DGUOK Protein, GST-tagged Wheat Germ GST
Human DGUOK-772H Recombinant Human DGUOK Protein, His-tagged E.coli His
Human DGUOK-6951HCL Recombinant Human DGUOK 293 Cell Lysate HEK293 N/A
Human DGUOK-6952HCL Recombinant Human DGUOK 293 Cell Lysate HEK293 N/A
Human DGUOK-1011H Recombinant Human DGUOK Protein (40-277 aa), His-SUMO-tagged E.coli His/SUMO 40-277 aa
Human DGUOK-476H Recombinant Human DGUOK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DGUOK-753H Recombinant Human DGUOK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DGUOK-2509HF Recombinant Full Length Human DGUOK Protein, GST-tagged In Vitro Cell Free System GST 277 amino acids
Human DGUOK-753H-B Recombinant Human DGUOK Protein Pre-coupled Magnetic Beads HEK293
Human DGUOK-2174HFL Recombinant Full Length Human DGUOK Protein, C-Flag-tagged Mammalian cells Flag
Mouse Dguok-2541M Recombinant Mouse Dguok Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish DGUOK-5866Z Recombinant Zebrafish DGUOK Mammalian Cell His
Chicken DGUOK-3539C Recombinant Chicken DGUOK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DGUOK Related Articles

DGUOK involved in several pathways and played different roles in them. We selected most pathways DGUOK participated on our site, such as Metabolic pathways, Metabolism, Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGUOK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysADPGK;PSAT1;ATP6V1BA;GALNTL6;TDO2B;NAMPT;ATP6V1AA;PLCB3;IPPK
MetabolismACOT12;CES1;SLC26A1;CYP4T8;D2HGDH;PAICS;FAM213B;CKMT2;NUDT4
Metabolism of nucleotidesTM9SF1;NUDT18;ADSSL1;ADK;NUDT1;AK7A;NUDT5;ADSL;DGUOK
Purine metabolismFHIT;NPR1;ADSSL;NT5C2B;POLR2EB;NME2;ALLC;POLR2J2;PRUNE
Purine salvagePNP5B;DGUOK;TM9SF1;ADAL;DCK;ADA;ADK
purine deoxyribonucleosides salvage

DGUOK has several biochemical functions, for example, ATP binding, deoxyguanosine kinase activity, nucleoside kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGUOK itself. We selected most functions DGUOK had, and list some proteins which have the same functions with DGUOK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingHSPA5;UBE2R2;MYLK4;DHX32;P2RX7;STRADA;MAP3K3;XRCC2;Adcy4
deoxyguanosine kinase activity
nucleoside kinase activityUCK2A;DGUOK;UCK2B;UCK1;DCK;UCK2;TK1

DGUOK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGUOK here. Most of them are supplied by our site. Hope this information will be useful for your research of DGUOK.

PXN

Zheng, YW; Wang, AW; et al. B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. BLOOD 123:931-934(2014).
Sharma, S; Moon, CS; et al. Biomarkers in Parkinson's disease (recent update). NEUROCHEMISTRY INTERNATIONAL 63:201-229(2013).
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