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DHCR24

  • Official Full Name

    24-dehydrocholesterol reductase

  • Overview

    This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
  • Synonyms

    DHCR24; 24-dehydrocholesterol reductase; DCE; SELADIN1; Nbla03646; seladin-1; delta(24)-sterol reductase; seladin 1; diminuto/dwarf1 homolog; selective AD indicator 1; desmosterol-to-cholesterol enzyme; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHCR24-11962H Recombinant Human DHCR24, GST-tagged E.coli GST 217-516a.a.
Human DHCR24-105H Recombinant Human DHCR24 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DHCR24-106H Recombinant Human DHCR24 protein, GST-tagged Wheat Germ GST
Human DHCR24-6950HCL Recombinant Human DHCR24 293 Cell Lysate HEK293 N/A
Human DHCR24-731HF Recombinant Full Length Human DHCR24 Protein, GST-tagged In Vitro Cell Free System GST 516 amino acids
Human DHCR24-5686H Recombinant Human DHCR24 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DHCR24-754H-B Recombinant Human DHCR24 Protein Pre-coupled Magnetic Beads HEK293
Human DHCR24-1959H Recombinant Human DHCR24 Protein (Arg53-His516), N-His tagged E.coli N-His Arg53-His516
Human DHCR24-2126HFL Recombinant Full Length Human DHCR24 Protein, C-Flag-tagged Mammalian cells Flag
Human DHCR24-754H Recombinant Human DHCR24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dhcr24-2542M Recombinant Mouse Dhcr24 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cynomolgus Monkey DHCR24-462C Recombinant Cynomolgus DHCR24 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey DHCR24-208C Recombinant Cynomolgus Monkey DHCR24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DHCR24-208C-B Recombinant Cynomolgus Monkey DHCR24 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DHCR24-1931Z Recombinant Zebrafish DHCR24 Mammalian Cell His
Chicken DHCR24-2944C Recombinant Chicken DHCR24 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DHCR24 involved in several pathways and played different roles in them. We selected most pathways DHCR24 participated on our site, such as Cholesterol biosynthesis, Metabolic pathways, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHCR24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cholesterol biosynthesisDHCR24;PMVK;DHCR7;EBP;ARV1;CYP51A1;SREBF2;LBR
Metabolic pathwaysNAT2;GLUD2;KCNG4;BCKDHA;CDS1;UGT1A4;PIGC;ATP5A1;IDI1
MetabolismITPKB;BCHE;SLC46A1;PDP2;UCP2;ALOX5B.3;CPNE1;LYVE1;OAZ2B
Metabolism of lipids and lipoproteinsBCHE;CHKA;AKR1C2;DGAT1B;CYP24A1;ACSF2;CETP;SIN3B;ARSF
Steroid biosynthesisCELL;MSMO1;NSDHL;FAXDC2;SC4MOL;HSD17B7;SQLE;DHCR24;DHCR7
Tryptophan metabolismTPH1B;AOX3L1;ALDH9A1;CMTM2A;ASMT;ALDH9A1B;MAOB;AADAT;AOC1
cholesterol biosynthesis IDHCR24;LBR;EBP;DHCR7
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)DHCR24;LBR;EBP

DHCR24 has several biochemical functions, for example, delta24(24-1) sterol reductase activity, delta24-sterol reductase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHCR24 itself. We selected most functions DHCR24 had, and list some proteins which have the same functions with DHCR24. You can find most of the proteins on our site.

Function Related Protein
delta24(24-1) sterol reductase activity
delta24-sterol reductase activity
enzyme bindingGOLPH3;TAL1;POR;SLC27A2;CCND1;PPP1R3D;NKX2-1;SLC12A3;CYP3A4
flavin adenine dinucleotide bindingGFER;DUS4L;DPYD;LDHD;PPOX;FMO3;FMO1;ACADM;NOS3
oxidoreductase activity, acting on CH-OH group of donorsDHCR24;AOX4;AOX3;XDH;AGPS;AOX1;AOX3L1;GULO
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptorDHCR24;SRD5A3;LBR;TM7SF2;BDH2
peptide antigen bindingMHC1UFA;TUBB3;HLA-C;MHC1UJA;HLA-A;MHC1ZE;HLA-B;MHC1UXA2;HLA-DRB5

DHCR24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHCR24 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHCR24.

env; 15-deoxy-delta(12,14; ssrna_ug; IKBKB; Atp2a2; GBA; Nedd1; Fbl; SNCA; Jup; CKAP5; Ufl1; q99ib8-pro_0000045602; SLC38A1

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