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DHCR7

  • Official Full Name

    7-dehydrocholesterol reductase

  • Overview

    This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
  • Synonyms

    DHCR7; 7-dehydrocholesterol reductase; SLOS, Smith Lemli Opitz syndrome; 7 dehydrocholesterol reductase; 7 DHC reductase; Delta 7 dehydrocholesterol reductase; Putative sterol reductase SR 2; Sterol Delta; 7-DHC reductase; sterol delta-7-reductase; putative sterol reductase SR-2; delta-7-dehydrocholesterol reductase; SLOS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Bovine
  • Chicken
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Protein Conjugation
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHCR7-2582H Recombinant Human DHCR7 Protein, GST-tagged Wheat Germ GST
Human DHCR7-6949HCL Recombinant Human DHCR7 293 Cell Lysate HEK293 N/A
Human DHCR7-2800H Recombinant Human DHCR7 Protein, His-tagged, OVA Conjugated Protein Conjugation N-His His449-Ala464
Human DHCR7-479H Recombinant Human DHCR7 Protein, His/GST-tagged E.coli His/GST Cys61~Leu153
Human DHCR7-2510HF Recombinant Full Length Human DHCR7 Protein, GST-tagged In Vitro Cell Free System GST 475 amino acids
Mouse DHCR7-4553M Recombinant Mouse DHCR7 Protein Mammalian Cell His
Mouse DHCR7-2352M-B Recombinant Mouse DHCR7 Protein Pre-coupled Magnetic Beads HEK293
Mouse DHCR7-2352M Recombinant Mouse DHCR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DHCR7-1858R Recombinant Rat DHCR7 Protein Mammalian Cell His
Rat DHCR7-1516R Recombinant Rat DHCR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DHCR7-1516R-B Recombinant Rat DHCR7 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL34220BF Recombinant Full Length Bovine 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system His Full Length (1-475aa)
Bovine DHCR7-293B Recombinant Bovine DHCR7 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-475aa
Danio rerio (Zebrafish) (Brachydanio rerio) RFL32768DF Recombinant Full Length Danio Rerio 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system His Full Length (1-478)
Homo sapiens (Human) RFL2095HF Recombinant Full Length Human 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system His Full Length (1-475)
Xenopus laevis (African clawed frog) RFL11704XF Recombinant Full Length Xenopus Laevis 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL3431XF Recombinant Full Length Xenopus Tropicalis 7-Dehydrocholesterol Reductase(Dhcr7) Protein, His-Tagged E.coli expression system His Full Length (1-473)
Zebrafish DHCR7-11477Z Recombinant Zebrafish DHCR7 Mammalian Cell His
Chicken DHCR7-4340C Recombinant Chicken DHCR7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DHCR7 involved in several pathways and played different roles in them. We selected most pathways DHCR7 participated on our site, such as Activation of gene expression by SREBF (SREBP), Cholesterol biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of gene expression by SREBF (SREBP)SREBF2;NFYBA;DHCR7;NCOA2;CARM1;MTF1;NFYAL;CYP51A1;NFYBB
Cholesterol biosynthesisEBP;LBR;DHCR24;SREBF2;ARV1;PMVK;CYP51A1;DHCR7
Metabolic pathwaysPANK4;GCNT1;POLG2;PYCR2;CYP21A2;COQ5;SAT2B;PGM2;IDO2
MetabolismSLC27A5;Sult2a6;COX7C;CPNE7;CYP2K6;PMVK;CERS4A;SLC5A9;AZIN1B
Metabolism of lipids and lipoproteinsAgmo;PMVK;GC;ACOT11A;ARV1;SLC44A5B;COQ6;CPNE6;OSBP
Regulation of cholesterol biosynthesis by SREBP (SREBF)INSIG1;DHCR7;YY2;PMVK;NFYAL;SREBF2;INSIG2;NFYBA;NFYBB
Steroid biosynthesisTM7SF2;SQLEA;SOAT2;LSS;CYP51;SC5DL;FAXDC2;SQLE;SC5D
cholesterol biosynthesis IDHCR24;DHCR7;EBP;LBR

DHCR7 has several biochemical functions, for example, 7-dehydrocholesterol reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHCR7 itself. We selected most functions DHCR7 had, and list some proteins which have the same functions with DHCR7. You can find most of the proteins on our site.

Function Related Protein
7-dehydrocholesterol reductase activity

DHCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHCR7.

TOR1A; FADS1; ILK; NDN; TNIK; q8czf9_yerpe; Cep152; 15-deoxy-delta(12,14; E2F3; Atp2a2; LTN1; 1C; ERBB2; Bmpr1a; Smn1; P; Hspa14; AGO2

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