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DHDH

  • Official Full Name

    dihydrodiol dehydrogenase (dimeric)

  • Overview

    This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
  • Synonyms

    DHDH; dihydrodiol dehydrogenase (dimeric); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; HUM2DD; D-xylose 1-dehydrogenase; 3-deoxyglucosone reductase; D-xylose-NADP dehydrogenase; 2DD;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHDH-11965H Recombinant Human DHDH, His-tagged E.coli His 1-334a.a.
Human DHDH-2584H Recombinant Human DHDH Protein, GST-tagged Wheat Germ GST
Human DHDH-468HCL Recombinant Human DHDH cell lysate N/A
Human DHDH-4938H Recombinant Human DHDH protein, GST-tagged E.coli GST 1-334aa
Human DHDH-6662H Recombinant Human DHDH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DHDH-2525HF Recombinant Full Length Human DHDH Protein, GST-tagged In Vitro Cell Free System GST 334 amino acids
Mouse DHDH-4555M Recombinant Mouse DHDH Protein Mammalian Cell His
Mouse Dhdh-2544M Recombinant Mouse Dhdh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DHDH-2353M-B Recombinant Mouse DHDH Protein Pre-coupled Magnetic Beads HEK293
Mouse DHDH-2353M Recombinant Mouse DHDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DHDH-463C Recombinant Cynomolgus DHDH Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey DHDH-209C Recombinant Cynomolgus Monkey DHDH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DHDH-209C-B Recombinant Cynomolgus Monkey DHDH Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DHDH Related Articles

DHDH involved in several pathways and played different roles in them. We selected most pathways DHDH participated on our site, such as Pentose and glucuronate interconversions, Metabolism of xenobiotics by cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsUGT1A6;AKR1B1L;DHDH;KL;SORD;AKR1B8;UGT1A7C;ALDH2.1;ALDH1B1
Metabolism of xenobiotics by cytochrome PGSTT2B;GSTM7;GSTM2;UGT1A7;HSD11B1;GSTM5;GSTA2;UGT2A3;EPHX1

DHDH has several biochemical functions, for example, D-xylose 1-dehydrogenase (NADP+) activity, NAD(P)+ transhydrogenase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHDH itself. We selected most functions DHDH had, and list some proteins which have the same functions with DHDH. You can find most of the proteins on our site.

Function Related Protein
D-xylose 1-dehydrogenase (NADP+) activityDHDHL;DHDH
NAD(P)+ transhydrogenase activityNNT;DHDH
electron carrier activityCIAPIN1;GCDH;DERL3;ME1;AKR7A3;NDUFS6;SDHC;ACAD11;AKR1A1
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityDHDH;AKR1C3;AKR1C2;AKR1C21

DHDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHDH here. Most of them are supplied by our site. Hope this information will be useful for your research of DHDH.

Aro-Karkkainen, N; Toivari, M; et al. L-Arabinose/D-galactose 1-dehydrogenase of Rhizobium leguminosarum bv. trifolii characterised and applied for bioconversion of L-arabinose to L-arabonate with Saccharomyces cerevisiae. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 98:9653-9665(2014).
Meneely, KM; Lamb, AL; et al. Two Structures of a Thiazolinyl Imine Reductase from Yersinia enterocolitica Provide Insight into Catalysis and Binding to the Nonribosomal Peptide Synthetase Module of HMWP1. BIOCHEMISTRY 51:9002-9013(2012).
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