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DHRS9

  • Official Full Name

    dehydrogenase/reductase (SDR family) member 9

  • Overview

    3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.
  • Synonyms

    DHRS9; dehydrogenase/reductase (SDR family) member 9; dehydrogenase/reductase SDR family member 9; 3 alpha hydroxysteroid dehydrogenase; 3alpha HSD; NADP dependent retinol dehydrogenase/reductase; RDH15; RDHL; retinol dehydrogenase homolog; RETSDR8; SDR9C4; short chain dehydrogenase/reductase family 9C; member 4; 3-@alpha-HSD; 3-@alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; DHRS9_HUMAN; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHE2; RDHTBE; Retinol dehydrogenase, tracheobronchiol epithelail cell-specific; SDR family, member 9; short chain dehydrogenase/reductase family 9; short chain dehydrogenase/reductase family 9C, member 4; Short chain dehydrogenase/reductase retSDR8; Short-chain dehydrogenase/reductase retSDR8; OTTHUMP00000163043; OTTHUMP00000204923; OTTHUMP00000204925; OTTHUMP00000204926; OTTHUMP00000205057; 3ALPHA-HSD;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHRS9-2603H Recombinant Human DHRS9 Protein, GST-tagged Wheat Germ GST
Human DHRS9-270H Recombinant Human DHRS9 protein, His-tagged E.coli His Arg18-Val319
Human DHRS9-1561H Recombinant Human Dehydrogenase/Reductase (SDR Family) Member 9, His-tagged E.coli His
Human DHRS9-6934HCL Recombinant Human DHRS9 293 Cell Lysate HEK293 N/A
Human DHRS9-2548HF Recombinant Full Length Human DHRS9 Protein, GST-tagged In Vitro Cell Free System GST 319 amino acids
Human DHRS9-1997H Recombinant Human DHRS9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DHRS9-3736H Recombinant Human DHRS9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Dhrs9-2552M Recombinant Mouse Dhrs9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat DHRS9-1863R Recombinant Rat DHRS9 Protein Mammalian Cell His
Rat DHRS9-1521R-B Recombinant Rat DHRS9 Protein Pre-coupled Magnetic Beads HEK293
Rat DHRS9-1521R Recombinant Rat DHRS9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DHRS9-10010Z Recombinant Zebrafish DHRS9 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DHRS9 Related Articles

DHRS9 involved in several pathways and played different roles in them. We selected most pathways DHRS9 participated on our site, such as Metabolic pathways, RA biosynthesis pathway, Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHRS9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysATP5J2;NME2;AMT;MTHFD1B;ZNF408;PNAT10;GBA;OXSM;MMAB
RA biosynthesis pathwayDHRS9;ADH8B;SDR16C5;DHRS4;CRABP1;RDH10;RDH7;RDH14B;ALDH8A1
Retinol metabolismCYP4A12A;CYP3A7-CYP3AP1;CYP2C70;SDR16C5A;ADH2-1;CYP3A25;CYP2C18;LRAT;DHRS4L2
Signal TransductionSKIB;MOB1BA;PPY;ARHGEF17;TAX1BP3;C;GPR55;PTHRP2;ABR
Signaling by Retinoic AcidFABP11A;AKR1C6;RDH14;PDK2;CRABP1B;PDK2B;CRABP2A;RDH13;DHRS9
The canonical retinoid cycle in rods (twilight vision)ABCA4A;RLBP1A;MYO7AA;IRBP;RPE65B;SDR9C7;DHRS9;RLBP1B;RDH10
Visual phototransductionMYO7AA;RDH12;BCO2A;GRK7;DHRS3;APOA4B.2;RLBP1;RLN1;NMT1B
retinol biosynthesisDHRS4;DHRS9;RBP5;CES5A

DHRS9 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, racemase and epimerase activity, retinol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHRS9 itself. We selected most functions DHRS9 had, and list some proteins which have the same functions with DHRS9. You can find most of the proteins on our site.

Function Related Protein
alcohol dehydrogenase (NAD) activityADH1;ADH8B;ADH8A;ADH1A;ADH7;ADH6;ADH4;ADH5;DHRS9
racemase and epimerase activity
retinol dehydrogenase activityDHRS3;RDH12;BMP2;RDH5;ADH1;AKR1C3;RDH1;HSD17B6;RDH11
testosterone dehydrogenase (NAD+) activityHSD17B6;HSD17B8;DHRS9;HSD17B1;AKR1C3;H2-KE6;HSD17B2

DHRS9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHRS9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHRS9.

Zubair, N; Kooperberg, C; et al. Genetic Variation Predicts Serum Lycopene Concentrations in a Multiethnic Population of Postmenopausal Women. JOURNAL OF NUTRITION 145:187-192(2015).
Lord, DM; Baran, AU; et al. BdcA, a Protein Important for Escherichia coli Biofilm Dispersal, Is a Short-Chain Dehydrogenase/Reductase that Binds Specifically to NADPH. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (6)

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Can lifestyle changes reduce the risk for DHRS9 mutations? 11/19/2022

There is currently no definitive way to alter the variation of the DHRS9 gene. However, healthy lifestyles, such as a balanced diet, moderate exercise, and good social interactions, may help reduce the risk of neurological disorders, although they may not directly improve the effects of the DHRS9 gene variant.

What is the effect of mutations in the DHRS9 gene? 11/16/2022

Mutations in the DHRS9 gene may cause abnormal function of retinoic acid-binding protein 1, which in turn affects retinoic acid metabolism and may increase the risk of neurological diseases.

Are DHRS9 gene variants associated with cognitive function 08/31/2022

Studies have shown that mutations in the DHRS9 gene may affect cognitive function, but the specific mechanism still needs further research.

What might be involved in future studies of the DHRS9 gene? 08/05/2022

Future research on the DHRS9 gene may involve more in-depth studies of molecular mechanisms, disease associations, and the development of therapeutics for this gene variant.

Are variants in the DHRS9 gene associated with behavioral traits? 07/04/2022

Studies have shown that mutations in the DHRS9 gene may be associated with certain behavioral traits, such as social skills, attention, and impulse control.

How to detect variants in the DHRS9 gene? 04/16/2020

Variants in the DHRS9 gene, including single nucleotide polymorphisms (SNPs), insertions/deletions, etc., can be detected by gene sequencing technology.

Customer Reviews (3)

Write a review
Reviews
10/24/2022

    DHRS9 is highly specific and active, and does not cause abnormal immune responses.

    04/22/2022

      The product is very mature and can be used for scientific research.

      10/19/2020

        The solubility is very good and can be easily dissolved in a variety of buffers.

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