DHRS9
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Official Full Name
dehydrogenase/reductase (SDR family) member 9
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Overview
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. -
Synonyms
DHRS9; dehydrogenase/reductase (SDR family) member 9; dehydrogenase/reductase SDR family member 9; 3 alpha hydroxysteroid dehydrogenase; 3alpha HSD; NADP dependent retinol dehydrogenase/reductase; RDH15; RDHL; retinol dehydrogenase homolog; RETSDR8; SDR9C4; short chain dehydrogenase/reductase family 9C; member 4; 3-@alpha-HSD; 3-@alpha-hydroxysteroid dehydrogenase; 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; DHRS9_HUMAN; NADP-dependent retinol dehydrogenase/reductase; RDH-E2; RDHE2; RDHTBE; Retinol dehydrogenase, tracheobronchiol epithelail cell-specific; SDR family, member 9; short chain dehydrogenase/reductase family 9; short chain dehydrogenase/reductase family 9C, member 4; Short chain dehydrogenase/reductase retSDR8; Short-chain dehydrogenase/reductase retSDR8; OTTHUMP00000163043; OTTHUMP00000204923; OTTHUMP00000204925; OTTHUMP00000204926; OTTHUMP00000205057; 3ALPHA-HSD;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- DHRS9 Related Articles
DHRS9 involved in several pathways and played different roles in them. We selected most pathways DHRS9 participated on our site, such as Metabolic pathways, RA biosynthesis pathway, Retinol metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHRS9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolic pathways | ATP5J2;NME2;AMT;MTHFD1B;ZNF408;PNAT10;GBA;OXSM;MMAB |
RA biosynthesis pathway | DHRS9;ADH8B;SDR16C5;DHRS4;CRABP1;RDH10;RDH7;RDH14B;ALDH8A1 |
Retinol metabolism | CYP4A12A;CYP3A7-CYP3AP1;CYP2C70;SDR16C5A;ADH2-1;CYP3A25;CYP2C18;LRAT;DHRS4L2 |
Signal Transduction | SKIB;MOB1BA;PPY;ARHGEF17;TAX1BP3;C;GPR55;PTHRP2;ABR |
Signaling by Retinoic Acid | FABP11A;AKR1C6;RDH14;PDK2;CRABP1B;PDK2B;CRABP2A;RDH13;DHRS9 |
The canonical retinoid cycle in rods (twilight vision) | ABCA4A;RLBP1A;MYO7AA;IRBP;RPE65B;SDR9C7;DHRS9;RLBP1B;RDH10 |
Visual phototransduction | MYO7AA;RDH12;BCO2A;GRK7;DHRS3;APOA4B.2;RLBP1;RLN1;NMT1B |
retinol biosynthesis | DHRS4;DHRS9;RBP5;CES5A |
DHRS9 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, racemase and epimerase activity, retinol dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHRS9 itself. We selected most functions DHRS9 had, and list some proteins which have the same functions with DHRS9. You can find most of the proteins on our site.
Function | Related Protein |
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alcohol dehydrogenase (NAD) activity | ADH1;ADH8B;ADH8A;ADH1A;ADH7;ADH6;ADH4;ADH5;DHRS9 |
racemase and epimerase activity | |
retinol dehydrogenase activity | DHRS3;RDH12;BMP2;RDH5;ADH1;AKR1C3;RDH1;HSD17B6;RDH11 |
testosterone dehydrogenase (NAD+) activity | HSD17B6;HSD17B8;DHRS9;HSD17B1;AKR1C3;H2-KE6;HSD17B2 |
DHRS9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHRS9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHRS9.
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is currently no definitive way to alter the variation of the DHRS9 gene. However, healthy lifestyles, such as a balanced diet, moderate exercise, and good social interactions, may help reduce the risk of neurological disorders, although they may not directly improve the effects of the DHRS9 gene variant.
Mutations in the DHRS9 gene may cause abnormal function of retinoic acid-binding protein 1, which in turn affects retinoic acid metabolism and may increase the risk of neurological diseases.
Studies have shown that mutations in the DHRS9 gene may affect cognitive function, but the specific mechanism still needs further research.
Future research on the DHRS9 gene may involve more in-depth studies of molecular mechanisms, disease associations, and the development of therapeutics for this gene variant.
Studies have shown that mutations in the DHRS9 gene may be associated with certain behavioral traits, such as social skills, attention, and impulse control.
Variants in the DHRS9 gene, including single nucleotide polymorphisms (SNPs), insertions/deletions, etc., can be detected by gene sequencing technology.
Customer Reviews (3)
Write a reviewDHRS9 is highly specific and active, and does not cause abnormal immune responses.
The product is very mature and can be used for scientific research.
The solubility is very good and can be easily dissolved in a variety of buffers.
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