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DHX58

  • Official Full Name

    DEXH (Asp-Glu-X-His) box polypeptide 58

  • Overview

    A full-length cDNA encoding mouse LGP2 was cloned by computational analysis, RT-PCR, and RACE of liver and mammary tissue total RNA. And human LGP2 was also cloned. Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
  • Synonyms

    DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58; LGP2; D11LGP2; D11lgp2e; RNA helicase LGP2; OTTHUMP00000164729; ortholog of mouse D11lgp2; Probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2 homolog; RNA helicase LGP2; RLR; D11LGP2E3; RIG-I-like receptor LGP2; EC 3.6.4.13;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • StrepII; Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHX58-11989H Recombinant Human DHX58, GST-tagged E.coli GST C-term-350a.a.
Human DHX58-2614H Recombinant Human DHX58 Protein, GST-tagged Wheat Germ GST
Human DHX58-984HCL Recombinant Human DHX58 cell lysate N/A
Human DHX58-760H Recombinant Human DHX58 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DHX58-2556HF Recombinant Full Length Human DHX58 Protein, GST-tagged In Vitro Cell Free System GST 678 amino acids
Human DHX58-0061H Recombinant Human DHX58 Protein (M1-D678), Flag tagged Mammalian cell Flag M1-D678
Human DHX58-2172HFL Recombinant Full Length Human DHX58 Protein, C-Flag-tagged Mammalian cells Flag
Human DHX58-0062H Recombinant Human DHX58 Protein (M1-D678), His/StrepII; Flag tagged Mammalian cell His/StrepII; Flag M1-D678
Human DHX58-760H-B Recombinant Human DHX58 Protein Pre-coupled Magnetic Beads HEK293
Mouse DHX58-4584M Recombinant Mouse DHX58 Protein Mammalian Cell His
Mouse DHX58-2370M-B Recombinant Mouse DHX58 Protein Pre-coupled Magnetic Beads HEK293
Mouse DHX58-2370M Recombinant Mouse DHX58 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DHX58-8207Z Recombinant Zebrafish DHX58 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DHX58 Related Articles

DHX58 involved in several pathways and played different roles in them. We selected most pathways DHX58 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX58 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RIG-I-like receptor signaling pathwayMAP3K7;ATG5;IFNPHI3;DHX58;Ifna11;ISG15;TRAF6;TANK;RIPK1

DHX58 has several biochemical functions, for example, ATP binding, DNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX58 itself. We selected most functions DHX58 had, and list some proteins which have the same functions with DHX58. You can find most of the proteins on our site.

Function Related Protein
ATP bindingRPS6KA3B;KIF2B;CAMKK2;ZAP70;RUVBL1;MAPK11;MAP4K6;NLRP5;HSPA2
DNA bindingTRP53;ZNF468;CDKN2A;SSH2;GTF2F2;ADNP;CRSP7;TOMM20A;OTX1B
double-stranded RNA bindingDDX58;OAS1A;DROSHA;IFIH1;RNASEN;APTX;MBNL1;OASL2;ADARB1
helicase activityHELZ;SMARCAL1;DDX11;SUPV3L1;ACTG2;ANXA1;DDX19;DDX6;MOV10
protein bindingHLCS;FBXW5;ANKRD1;HMGN4;SLC3A1;ACTN4;MAGEC2;EIF3I;CCT4
single-stranded RNA bindingCNBP;CBX6;IFIH1;RBMX;CBX4;TLR7;EIF2C3;PIWIL1;ANXA1
zinc ion bindingRNF222;POLR1A;BTR18;RNF168;ADAM32;MMP19;DTNB;ZDHHC22;RNF149

DHX58 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX58 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX58.

NKRF; EIF2AK2; EIF6; DHX30; STAU2; AGO2; DICER1; P/V/C; P/V; P/V; P/V

Kreit, M; Paul, S; et al. Inefficient Type I Interferon-Mediated Antiviral Protection of Primary Mouse Neurons Is Associated with the Lack of Apolipoprotein L9 Expression. JOURNAL OF VIROLOGY 88:3874-3884(2014).
Velazguez, AFC; Corby, J; et al. Design and cloning of fluorescent human helicase DHX58 (LGP2): Building the tools to study viral helicases. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 247:-(2014).
  • Q&As
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