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DHX8

  • Official Full Name

    DEAH (Asp-Glu-Ala-His) box polypeptide 8

  • Overview

    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.
  • Synonyms

    DHX8; DEAH (Asp-Glu-Ala-His) box polypeptide 8; DDX8, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8 (RNA helicase); ATP-dependent RNA helicase DHX8; HRH1; PRP22; PRPF22; ATP dependent RNA helicase DHX8; DDX 8; DDX8; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8 (RNA helicase); DEAD/H (Asp Glu Ala Asp/His) box polypeptide 8; DEAD/H box polypeptide 8; DEAH (Asp Glu Ala His) box polypeptide 8; DEAH box polypeptide 8; DEAH box protein 8; DHX 8; DHX8_HUMAN; HRH 1; PRP 22; PRPF 22; RNA helicase HRH 1; RNA helicase HRH1; DEAH-box protein 8; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DHX8-2615H Recombinant Human DHX8 Protein, GST-tagged Wheat Germ GST
Human DHX8-27450TH Recombinant Human DHX8 Wheat Germ N/A 100 amino acids
Human DHX8-2605H Recombinant Human DHX8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Dhx8-3752M Recombinant Mouse Dhx8, His-tagged E.Coli or Yeast His 1244
Mouse DHX8-4585M Recombinant Mouse DHX8 Protein Mammalian Cell His
Mouse DHX8-2371M Recombinant Mouse DHX8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dhx8-2562M Recombinant Mouse Dhx8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DHX8-2371M-B Recombinant Mouse DHX8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DHX8 involved in several pathways and played different roles in them. We selected most pathways DHX8 participated on our site, such as Spliceosome, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeU2AF1L4;CCDC12;SRSF6A;PRPF8;SNRPC;PQBP1;SF3B3;SLU7;TRA2B
mRNA processingPTBP1;CLK1;SNRPN;SNURF;SFPQ;RNASET2B;PTBP2;ZFP346;PSKH1

DHX8 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX8 itself. We selected most functions DHX8 had, and list some proteins which have the same functions with DHX8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMYO1H;PFKL;CDC34B;PRKCQ;ATP6V1B1;MAP3K2;GSK3AB;SMC5;GTF2F2B
ATP-dependent RNA helicase activityDDX43;DDX39AA;PL10;DDX17;DHX37;DDX3;DDX18;DDX25;TMEM38A
identical protein bindingTYROBP;MMP9;PCBD1;APP;SERPINA1D;ITGA2B;SHMT2;MTSS1;TTR
poly(A) RNA bindingRPS7;ATP5C1;NKRF;IFI203;EXOSC8;ZFML;SF1;FAM98A;CLNS1A
protein bindingFLT1;OBFC2B;CAMK2D;EP300;MED29;TCHP;PARP9;RNF135;TOMM70A

DHX8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX8 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX8.

CHERP; NKAP; ISY1; SRPK2; SRPK1; USP12; SMAD3; SMAD2; PRPF40A; MFAP1; PRPF38A; ZCCHC10; THOC1; SAP30BP; RBMX2

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