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DIABLO

  • Official Full Name

    diablo, IAP-binding mitochondrial protein

  • Overview

    This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Synonyms

    DIABLO; diablo, IAP-binding mitochondrial protein; SMAC; DFNA64; diablo homolog, mitochondrial; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DIABLO-377H Recombinant Human Diablo Homolog (Drosophila), T7-tagged E.coli T7
Human DIABLO-2617H Recombinant Human DIABLO Protein E.coli N/A
Human DIABLO-30927TH Recombinant Human DIABLO N/A
Human DIABLO-869H Active Recombinant Human DIABLO protein, His-tagged E.coli His Ala56-Asp239
Human DIABLO-23H Recombinant Human DIABLO protein, GST/His-tagged E.coli GST/His 1-239 aa (full-length)
Human DIABLO-30929TH Recombinant Human DIABLO, His-tagged E.coli His 239 amino acids
Human DIABLO-30928TH Recombinant Human DIABLO, T7 -tagged E.coli T7
Human DIABLO-2618H Recombinant Human DIABLO Protein Yeast N/A
Human DIABLO-2619H Recombinant Human DIABLO Protein, GST-tagged Wheat Germ GST
Human DIABLO-6927HCL Recombinant Human DIABLO 293 Cell Lysate HEK293 N/A
Human DIABLO-001H Recombinant Human DIABLO Protein, His-GST-tagged E.coli His/GST 1-239
Human DIABLO-4238H Recombinant Human DIABLO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DIABLO-4802H Recombinant Human DIABLO protein, GST-tagged E.coli GST 56-239aa
Human DIABLO-3897H Recombinant Human DIABLO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DIABLO-106H Recombinant Human DIABLO Protien, GST-tagged E. coli GST 1-239 aa
Human DIABLO-0878H Recombinant Human DIABLO Protein (A56-D239), GST tagged E.coli GST A56-D239
Human DIABLO-1338H Recombinant Human DIABLO Protein, His-tagged E.coli N-His Ala56-Asp239
Human DIABLO-2557HF Recombinant Full Length Human DIABLO Protein, GST-tagged In Vitro Cell Free System GST 186 amino acids
Human DIABLO-0877H Recombinant Human DIABLO Protein (A56-D239), Tag Free E.coli No tag A56-D239
Mouse DIABLO-4587M Recombinant Mouse DIABLO Protein Mammalian Cell His
Mouse Diablo-2563M Recombinant Mouse Diablo Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DIABLO-2373M Recombinant Mouse DIABLO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DIABLO-2373M-B Recombinant Mouse DIABLO Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DIABLO Related Articles
  • DIABLO Related Research Area

DIABLO involved in several pathways and played different roles in them. We selected most pathways DIABLO participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Apoptotic factor-mediated response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIABLO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ApoptosisRELA;TRP53;PIK3R3;IRF2A;IRAK3;CSF2RB;Fasl;CYCSB;BIDA
Apoptosis Modulation and SignalingPTRH2;DAXX;CAPNS1;BOK;HN1;BLK;SEPT4;BIK;CDKN2A
Apoptotic factor-mediated responseDIABLOA;DIABLOB;DIABLO
Caspase cascade in apoptosisDFFA;ACTA1;LMNB1;CRADD;GAS2;TOP1;DIABLO;CFL2;PARP1
Intrinsic Pathway for ApoptosisGZMC;GZMF;NMT1;DIABLOA;GZME;Gzmg;DIABLOB;DIABLO;BAXB
Programmed Cell DeathGZMF;DSG2;CASP6L1;DSP;HMGB2A;GZME;DIABLO;VIML;DAPK3
Release of apoptotic factors from the mitochondriaDIABLO;DIABLOA;DIABLOB
SMAC binds to IAPsDIABLOB;DIABLOA;DIABLO

DIABLO has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIABLO itself. We selected most functions DIABLO had, and list some proteins which have the same functions with DIABLO. You can find most of the proteins on our site.

Function Related Protein
protein bindingNSF;CNEP1R1;GLI1;ADAM17;RBM15;MEAF6;HIST3H3;CCDC121;GSG1

DIABLO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIABLO here. Most of them are supplied by our site. Hope this information will be useful for your research of DIABLO.

XIAP; BIRC2; BIRC7

Smolewski, P; Robak, P; et al. Pro-apoptotic effect of an anti-CD37 scFv-Fc fusion protein, in combination with the anti-CD20 antibody, ofatumumab, on tumour cells from B-cell malignancies. EUROPEAN JOURNAL OF CANCER 50:2677-2684(2014).
Hernandez-Jimenez, M; Sacristan, S; et al. Apoptosis-related proteins are potential markers of neonatal hypoxic-ischemic encephalopathy (HIE) injury. NEUROSCIENCE LETTERS 558:143-148(2014).
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