DIABLO
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Official Full Name
diablo, IAP-binding mitochondrial protein
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Overview
This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] -
Synonyms
DIABLO; diablo, IAP-binding mitochondrial protein; SMAC; DFNA64; diablo homolog, mitochondrial; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- GST|His
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- No tag
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- DIABLO Related Articles
- DIABLO Related Research Area
DIABLO involved in several pathways and played different roles in them. We selected most pathways DIABLO participated on our site, such as Apoptosis, Apoptosis Modulation and Signaling, Apoptotic factor-mediated response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIABLO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Apoptosis | RELA;TRP53;PIK3R3;IRF2A;IRAK3;CSF2RB;Fasl;CYCSB;BIDA |
Apoptosis Modulation and Signaling | PTRH2;DAXX;CAPNS1;BOK;HN1;BLK;SEPT4;BIK;CDKN2A |
Apoptotic factor-mediated response | DIABLOA;DIABLOB;DIABLO |
Caspase cascade in apoptosis | DFFA;ACTA1;LMNB1;CRADD;GAS2;TOP1;DIABLO;CFL2;PARP1 |
Intrinsic Pathway for Apoptosis | GZMC;GZMF;NMT1;DIABLOA;GZME;Gzmg;DIABLOB;DIABLO;BAXB |
Programmed Cell Death | GZMF;DSG2;CASP6L1;DSP;HMGB2A;GZME;DIABLO;VIML;DAPK3 |
Release of apoptotic factors from the mitochondria | DIABLO;DIABLOA;DIABLOB |
SMAC binds to IAPs | DIABLOB;DIABLOA;DIABLO |
DIABLO has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIABLO itself. We selected most functions DIABLO had, and list some proteins which have the same functions with DIABLO. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | NSF;CNEP1R1;GLI1;ADAM17;RBM15;MEAF6;HIST3H3;CCDC121;GSG1 |
DIABLO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIABLO here. Most of them are supplied by our site. Hope this information will be useful for your research of DIABLO.
XIAP; BIRC2; BIRC7
- Q&As
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