DIO2
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Official Full Name
deiodinase, iodothyronine, type II
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Overview
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
DIO2; deiodinase, iodothyronine, type II; type II iodothyronine deiodinase; type 2 DI; type-II 5 deiodinase; type-II 5-deiodinase; iodothyronine type II deiodinase; 5DII; DIOII; AI324267;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Fundulus heteroclitus (Killifish) (Mummichog)
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|MBP
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | DIO2-2628H | Recombinant Human DIO2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | DIO2-532H | Recombinant Human DIO2 | Mammalian Cell | His | ||
Human | DIO2-2798H | Recombinant Human DIO2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | DIO2-2798H-B | Recombinant Human DIO2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | DIO2-3650H | Recombinant Human DIO2 protein, GST-tagged | E.coli | GST | 171-273 aa | |
Mouse | Dio2-1340M | Recombinant Mouse Dio2 Protein, His-tagged | E.coli | N-His | Ser30-Phe259 | |
Rat | Dio2-8147R | Recombinant Rat Dio2 protein, His & MBP-tagged | E.coli | His/MBP | Ser30~Phe259 (Accession# P70551) | |
Rat | DIO2-1869R | Recombinant Rat DIO2 Protein | Mammalian Cell | His | ||
Rat | DIO2-1527R-B | Recombinant Rat DIO2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Dio2-1341R | Recombinant Rat Dio2 Protein, His&GST-tagged | E.coli | N-His&GST | Ser30-Thr129 | |
Rat | DIO2-1560R | Recombinant Rat DIO2 Protein (1-266 aa), His-tagged | Yeast | His | 1-266 aa | |
Rat | DIO2-1527R | Recombinant Rat DIO2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Bos taurus (Bovine) | RFL4865BF | Recombinant Full Length Bovine Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-269) | |
Fundulus heteroclitus (Killifish) (Mummichog) | RFL33665FF | Recombinant Full Length Fundulus Heteroclitus Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-266) | |
Homo sapiens (Human) | RFL30280HF | Recombinant Full Length Human Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-273) | |
Rattus norvegicus (Rat) | RFL23815RF | Recombinant Full Length Rat Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-266) | |
Sus scrofa (Pig) | RFL6341SF | Recombinant Full Length Pig Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-269) | |
Zebrafish | DIO2-12056Z | Recombinant Zebrafish DIO2 | Mammalian Cell | His | ||
Chicken | DIO2-5690C | Recombinant Chicken DIO2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- DIO2 Related Articles
DIO2 involved in several pathways and played different roles in them. We selected most pathways DIO2 participated on our site, such as Amine-derived hormones, Metabolism, Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Amine-derived hormones | TPH2;DBH;DIO2;CGA;DDC |
Metabolism | CYP2R1;SLC26A2;SURF1;EPM2A;THEM5;ARSK;SLC25A15A;MMS19;GC |
Metabolism of amino acids and derivatives | CKBA;PAOX;CKMT2A;FTCD;CKM;BHMT2;OAZ2;DCT;HIBADH |
Regulation of thyroid hormone activity | |
Selenium Metabolism and Selenoproteins | TRNAU1AP;SELK;FBXO17;SELENBP1;MSRB1;SELT;DIO2;CREM;SP3 |
Selenium Pathway | DIO2;CRP;SERPINA3;PRDX3;SELT;PRDX2;SELK;TXNRD3IT1;SEP15 |
Thyroid hormone signaling pathway | NCOR1;PLCD4;PIK3R2;MED27;PLCB2;NOTCH4;MED12L;ATP1A1;PFKP |
Thyroxine biosynthesis |
DIO2 has several biochemical functions, for example, selenium binding, thyroxine 5-deiodinase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIO2 itself. We selected most functions DIO2 had, and list some proteins which have the same functions with DIO2. You can find most of the proteins on our site.
Function | Related Protein |
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selenium binding | GPX1;DIO1;SEP15;RPH3A;DIO2;SELT;SELENBP1;SEPP1;GPX3 |
thyroxine 5-deiodinase activity | DIO3A;DIO2;DIO3;DIO1;DIO3B |
ubiquitin protein ligase binding | CKB;DTX1;TMEM173;TMEM189;EGR2;HSPA1B;HERC2;ABI2;HDAC6 |
DIO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIO2.
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