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DIO2

  • Official Full Name

    deiodinase, iodothyronine, type II

  • Overview

    The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    DIO2; deiodinase, iodothyronine, type II; type II iodothyronine deiodinase; type 2 DI; type-II 5 deiodinase; type-II 5-deiodinase; iodothyronine type II deiodinase; 5DII; DIOII; AI324267;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Fundulus heteroclitus (Killifish) (Mummichog)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DIO2-2628H Recombinant Human DIO2 Protein, GST-tagged Wheat Germ GST
Human DIO2-532H Recombinant Human DIO2 Mammalian Cell His
Human DIO2-2798H Recombinant Human DIO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DIO2-2798H-B Recombinant Human DIO2 Protein Pre-coupled Magnetic Beads HEK293
Human DIO2-3650H Recombinant Human DIO2 protein, GST-tagged E.coli GST 171-273 aa
Mouse Dio2-1340M Recombinant Mouse Dio2 Protein, His-tagged E.coli N-His Ser30-Phe259
Rat Dio2-8147R Recombinant Rat Dio2 protein, His & MBP-tagged E.coli His/MBP Ser30~Phe259 (Accession# P70551)
Rat DIO2-1869R Recombinant Rat DIO2 Protein Mammalian Cell His
Rat DIO2-1527R-B Recombinant Rat DIO2 Protein Pre-coupled Magnetic Beads HEK293
Rat Dio2-1341R Recombinant Rat Dio2 Protein, His&GST-tagged E.coli N-His&GST Ser30-Thr129
Rat DIO2-1560R Recombinant Rat DIO2 Protein (1-266 aa), His-tagged Yeast His 1-266 aa
Rat DIO2-1527R Recombinant Rat DIO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL4865BF Recombinant Full Length Bovine Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged E.coli expression system His Full Length (1-269)
Fundulus heteroclitus (Killifish) (Mummichog) RFL33665FF Recombinant Full Length Fundulus Heteroclitus Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged E.coli expression system His Full Length (1-266)
Homo sapiens (Human) RFL30280HF Recombinant Full Length Human Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged E.coli expression system His Full Length (1-273)
Rattus norvegicus (Rat) RFL23815RF Recombinant Full Length Rat Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged E.coli expression system His Full Length (1-266)
Sus scrofa (Pig) RFL6341SF Recombinant Full Length Pig Type Ii Iodothyronine Deiodinase(Dio2) Protein, His-Tagged E.coli expression system His Full Length (1-269)
Zebrafish DIO2-12056Z Recombinant Zebrafish DIO2 Mammalian Cell His
Chicken DIO2-5690C Recombinant Chicken DIO2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DIO2 Related Articles

DIO2 involved in several pathways and played different roles in them. We selected most pathways DIO2 participated on our site, such as Amine-derived hormones, Metabolism, Metabolism of amino acids and derivatives, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine-derived hormonesTPH2;DBH;DIO2;CGA;DDC
MetabolismCYP2R1;SLC26A2;SURF1;EPM2A;THEM5;ARSK;SLC25A15A;MMS19;GC
Metabolism of amino acids and derivativesCKBA;PAOX;CKMT2A;FTCD;CKM;BHMT2;OAZ2;DCT;HIBADH
Regulation of thyroid hormone activity
Selenium Metabolism and SelenoproteinsTRNAU1AP;SELK;FBXO17;SELENBP1;MSRB1;SELT;DIO2;CREM;SP3
Selenium PathwayDIO2;CRP;SERPINA3;PRDX3;SELT;PRDX2;SELK;TXNRD3IT1;SEP15
Thyroid hormone signaling pathwayNCOR1;PLCD4;PIK3R2;MED27;PLCB2;NOTCH4;MED12L;ATP1A1;PFKP
Thyroxine biosynthesis

DIO2 has several biochemical functions, for example, selenium binding, thyroxine 5-deiodinase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DIO2 itself. We selected most functions DIO2 had, and list some proteins which have the same functions with DIO2. You can find most of the proteins on our site.

Function Related Protein
selenium bindingGPX1;DIO1;SEP15;RPH3A;DIO2;SELT;SELENBP1;SEPP1;GPX3
thyroxine 5-deiodinase activityDIO3A;DIO2;DIO3;DIO1;DIO3B
ubiquitin protein ligase bindingCKB;DTX1;TMEM173;TMEM189;EGR2;HSPA1B;HERC2;ABI2;HDAC6

DIO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIO2.

Nassar, M; Halle, I; et al. Detection of long-term influence of prenatal temperature stimulation on hypothalamic type-II iodothyronine deiodinase in juvenile female broiler chickens using a novel immunohistochemical amplification protocol. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY 179:120-124(2015).
Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).
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