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DIO3

  • Official Full Name

    deiodinase, iodothyronine, type III

  • Overview

    The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3,5-triiodothyronine (T3) to inactive metabolites, 3,3,5-triiodothyronine (RT3) and 3,3-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
  • Synonyms

    DIO3; deiodinase, iodothyronine, type III; TXDI3; type III iodothyronine deiodinase; Type 3 DI; D3; 5DIII; Deiodinase iodothyronine type 3; Deiodinase iodothyronine type III; Dio 3; DIOIII; MGC124117; MGC124118; type-III 5 deiodinase; type-III 5-deiodinase; type 3 iodothyronine selenodeiodinase; iodothyronine deiodinase, placental type; thyroxine deiodinase type III (selenoprotein);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DIO3-2629H Recombinant Human DIO3 Protein, GST-tagged Wheat Germ GST
Human DIO3-3713H Recombinant Human DIO3 protein, His-tagged E.coli His 192-278 aa
Human DIO3-2565HF Recombinant Full Length Human DIO3 Protein, GST-tagged In Vitro Cell Free System GST 143 amino acids
Mouse DIO3-4595M Recombinant Mouse DIO3 Protein Mammalian Cell His
Mouse DIO3-2379M Recombinant Mouse DIO3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dio3-1342M Recombinant Mouse Dio3 Protein, His-tagged E.coli N-His Arg11-Arg277
Mouse DIO3-2379M-B Recombinant Mouse DIO3 Protein Pre-coupled Magnetic Beads HEK293
Rat DIO3-1870R Recombinant Rat DIO3 Protein Mammalian Cell His
Rat DIO3-1528R-B Recombinant Rat DIO3 Protein Pre-coupled Magnetic Beads HEK293
Rat Dio3-5658R Recombinant Rat Dio3 protein, His-tagged Yeast His 63-304aa (170:U→missing)
Rat DIO3-1528R Recombinant Rat DIO3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DIO3-385R Recombinant Rat DIO3 Protein, His/MBP-tagged E.coli His/MBP Arg11~Arg277
Rat DIO3-1603R Recombinant Rat DIO3 Protein (37-278 aa), His-tagged Yeast His 37-278 aa
Rat Dio3-4042R Recombinant Rat Dio3 protein, His-tagged E.coli His 63-304aa
Chicken DIO3-3832C Recombinant Chicken DIO3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DIO3 involved in several pathways and played different roles in them. We selected most pathways DIO3 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIO3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Thyroid hormone signaling pathwayMED14;SLC9A1;ACTG1;BAD;NOTCH3;PLCZ1;MED4;PLCG2;BMP4

DIO3 has several biochemical functions, for example, oxidoreductase activity, thyroxine 5-deiodinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DIO3 itself. We selected most functions DIO3 had, and list some proteins which have the same functions with DIO3. You can find most of the proteins on our site.

Function Related Protein
oxidoreductase activityTESCA;CYP7A1A;ADOB;CHML;GPX1B;HSD11B1L;HSD17B12B;CYP2J6;CYP2C54
thyroxine 5-deiodinase activityDIO1;DIO3A;DIO3B;DIO3;DIO2

DIO3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIO3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIO3.

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