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DIS3

  • Official Full Name

    DIS3 mitotic control homolog (S. cerevisiae)

  • Overview

    Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.
  • Synonyms

    DIS3; DIS3 mitotic control homolog (S. cerevisiae); KIAA1008; exosome complex exonuclease RRP44; dis3p; EXOSC11; exosome component 11; RRP44; Mitotic control protein dis3 homolog; Protein DIS3 homolog; Ribosomal RNA processing protein 44; Ribosomal RNA-processing protein 44; RRP44_HUMAN; 2810028N01Rik; bA555G22.1; RP11-342J4.3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DIS3-12004H Recombinant Human DIS3, His-tagged E.coli His 607-958a.a.
Human DIS3-6919HCL Recombinant Human DIS3 293 Cell Lysate HEK293 N/A
Human DIS3-6219H Recombinant Human DIS3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse DIS3-4602M Recombinant Mouse DIS3 Protein Mammalian Cell His
Mouse DIS3-2383M Recombinant Mouse DIS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dis3-2568M Recombinant Mouse Dis3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DIS3-2383M-B Recombinant Mouse DIS3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DIS3 involved in several pathways and played different roles in them. We selected most pathways DIS3 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DIS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA degradationPAN2;CNOT4;XRN2;LSM6;TOB1B;CNOT8;PABPC4;EXOSC7;EXOSC1

DIS3 has several biochemical functions, for example, 3-5-exoribonuclease activity, RNA binding, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DIS3 itself. We selected most functions DIS3 had, and list some proteins which have the same functions with DIS3. You can find most of the proteins on our site.

Function Related Protein
3-5-exoribonuclease activityERI1;PNPT1;EXOSC4;EXOSC3;ERI3;DOM3Z;ISG20;C16orf57;PAN2
RNA bindingZNF638;NOM1;DDX51;AGFG1A;CELF1;ADAD1;YBX1;CTU1;RBMS3
endonuclease activityG3BP1;OGG1;ANG;RNASEL4;ANG3;RNASEKA;SMG6;NTHL1;MRE11A
guanyl-nucleotide exchange factor activityCHRM4;PCP2;TBXA2R;ARHGEF37;VAV1;FGD4;VAV2;FGD2;FGD3
protein bindingCDKN1C;ZBTB7B;FGF7;RPUSD4;HSPA12B;LYL1;RPS13;HEMGN;DDC

DIS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DIS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DIS3.

EXOSC10; EXOSC3; EXOSC8; EXOSC2; EXOSC4; NME2; BABAM1; ZBTB17; hemA; NTMT1; ssrna_ug

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