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DKC1

  • Official Full Name

    dyskeratosis congenita 1, dyskerin

  • Overview

    This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Synonyms

    DKC1; dyskeratosis congenita 1, dyskerin; DKC; CBF5; DKCX; NAP57; NOLA4; XAP101; H/ACA ribonucleoprotein complex subunit 4; CBF5 homolog; snoRNP protein DKC1; nucleolar protein NAP57; nucleolar protein family A member 4; nopp140-associated protein of 57 kDa;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DKC1-261H Recombinant Human DKC1 protein, GST-tagged Wheat Germ GST 1 a.a. - 514 a.a.
Human DKC1-6916HCL Recombinant Human DKC1 293 Cell Lysate HEK293 N/A
Human DKC1-570HF Recombinant Full Length Human DKC1 Protein, GST-tagged In Vitro Cell Free System GST 514 amino acids
Human DKC1-685H Recombinant Human DKC1 Protein, His-tagged E.coli His Arg298~Leu465
Mouse Dkc1-686M Recombinant Mouse Dkc1 Protein, His-tagged E.coli His Arg298~Glu509
Rat DKC1-1875R Recombinant Rat DKC1 Protein Mammalian Cell His
Rat DKC1-1533R Recombinant Rat DKC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Dkc1-687R Recombinant Rat Dkc1 Protein, His-tagged E.coli His Lys298~Gly509
Rat DKC1-1533R-B Recombinant Rat DKC1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DKC1-1272R Recombinant Rhesus monkey DKC1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DKC1-1097R-B Recombinant Rhesus Macaque DKC1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DKC1-1097R Recombinant Rhesus Macaque DKC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DKC1-3393Z Recombinant Zebrafish DKC1 Mammalian Cell His
Chicken DKC1-2787C Recombinant Chicken DKC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DKC1 Related Articles

DKC1 involved in several pathways and played different roles in them. We selected most pathways DKC1 participated on our site, such as Cell Cycle, Chromosome Maintenance, Extension of Telomeres, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleRBL2;SMC3;DPF1;ANKLE2;SYNE1;WRAP53;CCP110;SGOL1;CDKN1B
Chromosome MaintenancePANE1;TERF2IP;RBBP7;TERF2;DNA2;CENPP;POLD3;DKC1;CENPQ
Extension of TelomeresRUVBL2;WRAP53;DKC1
Regulation of TelomerasePINX1;MXD1;CMTM2A;TNKS;NR2F2;DKC1;SP3
Ribosome biogenesis in eukaryotesRCL1;POP5;PWP2;GAR1;NOP10;NAT10;NMD3;FBL;SMFN
Telomere Extension By TelomeraseWRAP53;DKC1
Telomere MaintenanceDKC1;WRAP53

DKC1 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DKC1 itself. We selected most functions DKC1 had, and list some proteins which have the same functions with DKC1. You can find most of the proteins on our site.

Function Related Protein
RNA bindingPABPC1A;EIF1AXA;XPO5;NSUN3;RPL39L;PAPOLB;CPEB1B;PRAC;RPL38
poly(A) RNA bindingSTAU1;YTHDF1;RBM15B;TARDBP;UBA1;CELF2;MBNL2;UTP23;SNRPD2
protein bindingAGTR2;MAGEA2;NANOS2;SIGLEC5;CYTIP;NDUFA13;CCDC135;VASN;BRIP1
pseudouridine synthase activityPUSL1;PUS3;PUS10;DKC1;RPUSD4;PUS7L;TRUB2;RPUSD2;RPUSD1
telomerase RNA bindingNHP2;HNRNPU;NOP10;DKC1;WRAP53;TERT;HNRNPC;GAR1;PINX1
telomerase activityCCDC111;PTGES3;UAP1L1;DKC1;CTU1;TERT;PRIM2

DKC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKC1.

NAF1; WRAP53; RUVBL1

Cerrudo, CS; Gomez, DLM; et al. Novel Insights into the Evolution and Structural Characterization of Dyskerin Using Comprehensive Bioinformatics Analysis. JOURNAL OF PROTEOME RESEARCH 14:874-887(2015).
Gao, JJ; Roy, S; et al. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. ENVIRONMENTAL RESEARCH 136:462-469(2015).
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