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DLG1

  • Official Full Name

    discs, large homolog 1 (Drosophila)

  • Overview

    This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.
  • Synonyms

    DLG1; discs, large homolog 1 (Drosophila); discs, large (Drosophila) homolog 1; disks large homolog 1; discs large homolog 1; dJ1061C18.1.1; DLGH1; hdlg; presynaptic protein SAP97; SAP 97; SAP97; synapse associated protein 97; synapse-associated protein 97; SAP-97; DKFZp761P0818; DKFZp781B0426;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DLG1-2675H Recombinant Human DLG1 Protein, GST-tagged Wheat Germ GST
Human DLG1-9483HCL Recombinant Human DLG1 cell lysate HEK293T Myc/DDK
Human DLG1-1344H Recombinant Human DLG1 Protein, His-tagged E.coli N-His Ala686-Leu904
Mouse DLG1-4619M Recombinant Mouse DLG1 Protein Mammalian Cell His
Mouse DLG1-2396M-B Recombinant Mouse DLG1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DLG1-2396M Recombinant Mouse DLG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DLG1-1878R Recombinant Rat DLG1 Protein Mammalian Cell His
Rat Dlg1-1345R Recombinant Rat Dlg1 Protein, His-tagged E.coli N-His Ala686-Ala907
Rat DLG1-1537R-B Recombinant Rat DLG1 Protein Pre-coupled Magnetic Beads HEK293
Rat DLG1-1537R Recombinant Rat DLG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DLG1-1276R Recombinant Rhesus monkey DLG1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DLG1-1101R-B Recombinant Rhesus Macaque DLG1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DLG1-1101R Recombinant Rhesus Macaque DLG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DLG1-9933Z Recombinant Zebrafish DLG1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DLG1 Related Articles

DLG1 involved in several pathways and played different roles in them. We selected most pathways DLG1 participated on our site, such as Hippo signaling pathway, T cell receptor signaling pathway, HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwaySOX2;CCND2;FZD9;CRB1;PRKCZ;WNT1;ID2;WNT8B;WNT10B
T cell receptor signaling pathwayKRAS;NCK1;CD40LG;DBNLB;Il2;PIK3R2;CBLB;IFNG;CD3E; CD3D
HTLV-I infectionTNFRSF13C;POLD4;ANAPC5;TBPL2;WNT7A;TGFB2;AKT2;POLE3;WNT6
Viral carcinogenesisDNAJA3;ACTN1;CDK1;PMAIP1;LTBR;HIST1H4F;HDAC3;HIST1H2BL;STAT5A

DLG1 has several biochemical functions, for example, L27 domain binding, PDZ domain binding, guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DLG1 itself. We selected most functions DLG1 had, and list some proteins which have the same functions with DLG1. You can find most of the proteins on our site.

Function Related Protein
L27 domain bindingDLG1;LIN7A;LIN7B;LIN7C
PDZ domain bindingLNX2;ADRB1;FZD3;DLG1;DLG4;SNTB1;PDZK1;CFTR;ERC1
guanylate kinase activityMPP2;CARD11;DLG4B;DLG3;GUK1;MPP1;DLG2;GUK1B;DLG4
ion channel bindingFAM115C;LYN;SNTA1;ACTN3;KCNAB1;KCNQ3;GRINA;PDE4D;FAM115A
ionotropic glutamate receptor bindingDLG1L;DRD2;FLOT2;SHANK3;DLG4B;DLG1;GNAS;SHANK1;CACNG2
kinase bindingDLG3;JAKMIP2;TRIP6;CHP1;PRDX3;RPS3;STRADA;HPCA;JAKMIP1
mitogen-activated protein kinase kinase bindingMAPK8IP3;TRIB2;ARRB1;DLG1;RAF1;TAOK2;PIN1;TRIB1;MAP3K11
phosphatase bindingTRPC4AP;SH2D4A;CRY1;SH3GL1;SMAD2;TPRN;CTSC;PPP1R21;MAST2
potassium channel regulator activitySGK2;DPP10;YWHAE;DRD2;KCNAB2;KCNMB4;ARPP19;ANK2;KCNMB3
protein C-terminus bindingZBTB16;CEP135;GRIP1;CSK;TAF13;ID1;VGLL1;NCF2;CACNA1B
protein bindingTMEM11;MATN2;TMEM74;CHMP1B;TLDC2;ZNF792;HNRPLL;LGALS2;ARHGAP26
protein complex scaffoldSLC9A3R1;ISCU;SMARCD1;AXIN1;WWC1;TELO2;SLC9A3R2;CHCHD3;CAV1
protein kinase bindingSYK;EMP2;CDC25B;SKAP1;FAM83B;SPRY2;USF1;PDPK1;AP2A2

DLG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLG1.

Lrfn2; Nrcam; Grin2b; E6; Dlg4; Scn7a; Fzd1; Lrfn1; Fzd4

Hawkins, ED; Oliaro, J; et al. Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity. NATURE COMMUNICATIONS 4:-(2013).
Aoyagi, T; Takahashi, M; et al. The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation. VIRUS GENES 40:193-199(2010).
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