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DLG4

  • Official Full Name

    Dlg4 discs, large homolog 4 (Drosophila)

  • Synonyms

    DLG4; discs, large homolog 4 (Drosophila); disks large homolog 4; SAP-90; PSD-95 beta; PSD-95 alpha 2b; discs large homolog 4; synapse-associated protein 90; postsynaptic density protein 95; Dlgh4; PSD95; SAP90; PSD-95; SAP90A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • 6×His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DLG4-18H Recombinant Human DLG4 protein, His-tagged E.coli His
Human DLG4-31002TH Recombinant Human DLG4 Wheat Germ N/A 102 amino acids
Human DLG4-159H Recombinant Human DLG4 protein, GST-tagged Wheat Germ GST
Human DLG4-152H Recombinant Human DLG4 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DLG4-6910HCL Recombinant Human DLG4 293 Cell Lysate HEK293 N/A
Human DLG4-902H Recombinant Human DLG4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DLG4-1970H Recombinant Human DLG4 Protein (Ile6-Ala249), N-His tagged E.coli N-His Ile6-Ala249
Human DLG4-727HF Recombinant Full Length Human DLG4 Protein, GST-tagged In Vitro Cell Free System GST 767 amino acids
Human DLG4-1969H Recombinant Human DLG4 Protein (Ile6-Leu724), N-His tagged E.coli N-His Ile6-Leu724
Human DLG4-4905HFL Recombinant Full Length Human DLG4 protein, Flag-tagged Mamanlian cells Flag
Human DLG4-32H Recombinant Human DLG4 Protein (Mut), N-6×His tagged E.coli N-6×His
Human DLG4-1971H Recombinant Human DLG4 Protein (Ile6-Ser415), N-His tagged E.coli N-His Ile6-Ser415
Human DLG4-33H Recombinant Human DLG4 Protein (WT), N-6×His tagged E.coli N-6×His
Mouse DLG4-4622M Recombinant Mouse DLG4 Protein Mammalian Cell His
Mouse DLG4-2397M Recombinant Mouse DLG4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dlg4-2576M Recombinant Mouse Dlg4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DLG4-2397M-B Recombinant Mouse DLG4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dlg4-1346M Recombinant Mouse Dlg4 Protein, His-tagged E.coli N-His Met1-Ser393
Rat DLG4-1881R Recombinant Rat DLG4 Protein Mammalian Cell His
Rat DLG4-1540R-B Recombinant Rat DLG4 Protein Pre-coupled Magnetic Beads HEK293
Rat DLG4-1540R Recombinant Rat DLG4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DLG4 Related Articles
  • DLG4 Related Research Area

DLG4 involved in several pathways and played different roles in them. We selected most pathways DLG4 participated on our site, such as ARMS-mediated activation, Activation of Ca-permeable Kainate Receptor, Activation of Kainate Receptors upon glutamate binding, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationPEA15;SPTA1;PAQR3A;DUSP5;FGFR1B;DUSP6;SPRED3;KLB;SPTBN2
Activation of Ca-permeable Kainate ReceptorNCALDA;DLG1L;DLG4;DLG3
Activation of Kainate Receptors upon glutamate bindingDLG3;GNB5;DLG4;NCALDA;DLG1L
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsADCY3;SLC14A2;CREB1B;PDPK1A;DLG4;AKAP9;ADCY1;NEFLB;ADCY8
Axon guidanceROCK1;RND1;RNF8;CNTN1;NFATC3;SLIT1;SEMA4C;DUSP7;EPHB3A
CREB phosphorylation through the activation of CaMKIIAKAP9;DLG4;SLC14A2;NEFLB;NETO2;CREB1B
CREB phosphorylation through the activation of RasAKAP9;NEFLB;SLC14A2;PDPK1A;DLG4
Cocaine addictionCREB3L3;CDK5;MAOB;DRD1;GRIA2;FOSB;MAOA;GPSM1;CREB3L1

DLG4 has several biochemical functions, for example, D1 dopamine receptor binding, P2Y1 nucleotide receptor binding, PDZ domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLG4 itself. We selected most functions DLG4 had, and list some proteins which have the same functions with DLG4. You can find most of the proteins on our site.

Function Related Protein
D1 dopamine receptor bindingDRD3;PTPN11;DLG4;ARRB2;ATP1A3;GNAS;CAV2;AGTR1A
P2Y1 nucleotide receptor binding
PDZ domain bindingATP2B1B;FZD1;LNX1;SLC22A5;F11R;SNTB1;GRIK5;CFTR;GRASP
acetylcholine receptor bindingRAPSN;DLG4;KCNS1;RER1;JAK2;APP;RIC3;NRXN1;UBXN2A
beta-1 adrenergic receptor bindingDLG4;MAGI2
guanylate kinase activityGUK1;DLG1;CARD11;GUK1A;MPP1;DLG4B;TJP2;DLG1L;DLG4
ionotropic glutamate receptor bindingCANX;GNAS;DLG4;FLOT2;DLG1;CACNG2;DLG4B;SHANK1;ADRB2
kinase bindingHAP1;GFAP;ATF5;TENC1;PER3;PPP1R9B;CAB39;ABI2;PRDX3
neuroligin family protein bindingDLG4;NRXN1;NRXN2;NRXN3
protein C-terminus bindingXRCC5;EFHC1;SCLT1;DLG4;MLLT4;OPRL1;BCL10;ERCC2;NEIL1
protein bindingTXNDC9;CLOCK;CDK18;USP10;ZFP932;LMF2;DHX38;ABL1;MAU2
protein complex bindingSTK11;C8G;RAP1B;RNF40;NCOA1;CALY;CDK4;ATP6V1B1;RELA
protein phosphatase bindingMVP;VCP;FGF19;PIK3R2;PPP6R3;MAP3K5;EIF2AK3;GRB2;RPA3
scaffold protein bindingNLGN4Y;PANX1;LRP4;NLRP1;SRC;ATP2B4;TREM1;MAPK3;ADCY6

DLG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLG4.

Kcna4; ERBB4; Dlgap1; KCNA4

Dorostkar, MM; Burgold, S; et al. Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model. BRAIN 137:3319-3326(2014).
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