Background
Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP) is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post synaptic densityThis gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK and PSD-95 proteins fascilitating the assembly of the post synaptic density of neurons.Dlgap1 has five 14-amino acid repeats and three Pro-rich portions.