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DLX4

  • Official Full Name

    distal-less homeobox 4

  • Overview

    Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
  • Synonyms

    DLX4; distal-less homeobox 4; DLX7, DLX9; homeobox protein DLX-4; BP1; DLX8; beta protein 1; homeobox protein DLX-7; homeobox protein DLX-8; distal-less homeo box 7; distal-less homeo box 9; DLX7; DLX9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • HIS
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DLX4-5388H Recombinant Human Distal-less Homeobox 4 E.coli N/A
Human DLX4-068H Recombinant Human DLX4 Protein, HIS-tagged E.coli HIS
Human DLX4-2694H Recombinant Human DLX4 Protein, GST-tagged Wheat Germ GST
Human DLX4-6904HCL Recombinant Human DLX4 293 Cell Lysate HEK293 N/A
Human DLX4-6905HCL Recombinant Human DLX4 293 Cell Lysate HEK293 N/A
Human DLX4-4006HF Recombinant Full Length Human DLX4 Protein, GST-tagged In Vitro Cell Free System GST 240 amino acids
Mouse DLX4-4637M Recombinant Mouse DLX4 Protein Mammalian Cell His
Mouse DLX4-2406M-B Recombinant Mouse DLX4 Protein Pre-coupled Magnetic Beads HEK293
Mouse DLX4-2406M Recombinant Mouse DLX4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DLX4 involved in several pathways and played different roles in them. We selected most pathways DLX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DLX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DLX4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLX4 itself. We selected most functions DLX4 had, and list some proteins which have the same functions with DLX4. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingMYPOP;RFX1A;SIX4;BATF3;NR3C1;MXD1;NKX6;PHOX2B;TBX20
protein bindingTRIM10;FZD2;PARN;EPN2;Anks6;NOL6;TRP53;REV1;PPP2R2A
sequence-specific DNA bindingPRRX1A;NR4A2A;PAX2A;CUX1;VENTX;HOXA13B;E2F5;CREMB;CREBL2
transcription factor activity, sequence-specific DNA bindingZFP641;NKX2;DMRTC1B;TFDP2;ZNF187;RARAA;IRF2;ZKSCAN6;SCAND3
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingASCL1;BCL11A;TCF21;CREBBP;CC2D1B;HSF1;NKX6;ETS2;HOXA2

DLX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLX4.

SP1; SMAD4; SMAD2; ABL1; FYN; SRC; NCK1; PLCG1; PIK3R1; CRK; GRB2

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