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DLX5

  • Official Full Name

    distal-less homeobox 5

  • Overview

    This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation.
  • Synonyms

    DLX5; distal-less homeobox 5; distal less homeo box 5; homeobox protein DLX-5; distal-less homeo box 5; split hand/foot malformation type 1 with sensorineural hearing loss; SHFM1D;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DLX5-28H Recombinant Human DLX5 protein, GST-tagged Wheat Germ GST
Human DLX5-2926H Recombinant Human Distal-less Homeobox 5, His-tagged E.coli His
Human DLX5-6903HCL Recombinant Human DLX5 293 Cell Lysate HEK293 N/A
Human DLX5-301106H Recombinant Human DLX5 protein, GST-tagged E.coli GST Met1-Tyr289
Human DLX5-600HF Recombinant Full Length Human DLX5 Protein, GST-tagged In Vitro Cell Free System GST 289 amino acids
Mouse DLX5-4638M Recombinant Mouse DLX5 Protein Mammalian Cell His
Mouse DLX5-2407M Recombinant Mouse DLX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DLX5-2407M-B Recombinant Mouse DLX5 Protein Pre-coupled Magnetic Beads HEK293
Rat DLX5-1889R Recombinant Rat DLX5 Protein Mammalian Cell His
Rat DLX5-1548R-B Recombinant Rat DLX5 Protein Pre-coupled Magnetic Beads HEK293
Rat DLX5-1548R Recombinant Rat DLX5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken DLX5-5735C Recombinant Chicken DLX5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DLX5 Related Articles
  • DLX5 Related Research Area

DLX5 involved in several pathways and played different roles in them. We selected most pathways DLX5 participated on our site, such as Neural Crest Differentiation, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neural Crest DifferentiationFOXD3;PHOX2B;MIA;DLL3;OLIG3;TFAP2A;MBP;PRTG;CDH7
Signaling pathways regulating pluripotency of stem cellsPOU5F1;RAF1;SMAD2;HESX1;INHBB;MAPK3;IGF1R;HAND1;BMPR2

DLX5 has several biochemical functions, for example, HMG box domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLX5 itself. We selected most functions DLX5 had, and list some proteins which have the same functions with DLX5. You can find most of the proteins on our site.

Function Related Protein
HMG box domain bindingGATA3;PAX3;HOXC4;SP1;OLIG2;MEOX1;DLX5;EGR2;ALX4
RNA polymerase II core promoter proximal region sequence-specific DNA bindingAGO1;TFE3A;LEF1;NFAT5;CTCF;SIX1;ZNF664;ELK1;CUX2
transcription regulatory region DNA bindingHNRNPL;AIRE;CDK5RAP2;TAF2;GABPA;GLI1;SOX6;NR1D1;TBX21
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingTFAP2C;NKX2-5;FLI1;HNRNPK;NDN;GMEB1;HOXC11;GATA3;CAMTA1

DLX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLX5.

Senga, Y; Yoshioka, K; et al. Expression and gene knockdown of zebrafish Ca2+/calmodulin-dependent protein kinase I delta-LL. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 540:41-52(2013).
Scullen, T; Santo, L; et al. Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy. LEUKEMIA 27:1715-1721(2013).
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