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DMBT1

  • Official Full Name

    deleted in malignant brain tumors 1

  • Overview

    Loss of sequences from human chromosome 10q has been associated with the progression of human cancers.The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line.DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized.The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID).Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition.This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.
  • Synonyms

    DMBT1; deleted in malignant brain tumors 1; deleted in malignant brain tumors 1 protein; GP340; muclin; SAG; gp-340; hensin; glycoprotein 340; salivary agglutinin; surfactant pulmonary-associated D-binding protein; FLJ61058; MGC164738;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DMBT1-3231H Recombinant Human DMBT1, His tagged Human Cell His
Human DMBT1-26786TH Recombinant Human DMBT1 Wheat Germ N/A 109 amino acids
Human DMBT1-2700H Recombinant Human DMBT1 Protein, GST-tagged Wheat Germ GST
Human DMBT1-2407HCL Recombinant Human DMBT1 cell lysate Human Cell N/A
Human DMBT1-1351H Recombinant Human DMBT1 Protein, His-tagged E.coli N-His Cys2008-Arg2413
Mouse DMBT1-4641M Recombinant Mouse DMBT1 Protein Mammalian Cell His
Mouse DMBT1-2409M-B Recombinant Mouse DMBT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DMBT1-2409M Recombinant Mouse DMBT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DMBT1-1890R Recombinant Rat DMBT1 Protein Mammalian Cell His
Rat DMBT1-1549R-B Recombinant Rat DMBT1 Protein Pre-coupled Magnetic Beads HEK293
Rat DMBT1-1549R Recombinant Rat DMBT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DMBT1 Related Articles
  • DMBT1 Related Research Area

DMBT1 involved in several pathways and played different roles in them. We selected most pathways DMBT1 participated on our site, such as Metabolism of proteins, Salivary secretion, Surfactant metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMBT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of proteinsGPR116;IGFALS;MUCL1;DPH3;SPON2;CPA3;MTX1;B3GALTL;SPCS3
Salivary secretionITPR3;ATP1A2;PLCB1;VAMP2;LYZ;CD38;DMBT1;ATP2B1;RYR3
Surfactant metabolismLMCD1;SLC34A2A;DMBT1;SFTPC;CKAP4;SFTPBB;CCDC59;GATA6;CTSH

DMBT1 has several biochemical functions, for example, calcium-dependent protein binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DMBT1 itself. We selected most functions DMBT1 had, and list some proteins which have the same functions with DMBT1. You can find most of the proteins on our site.

Function Related Protein
calcium-dependent protein bindingSEC31A;ANXA2;STX2;MYO1D;ANXA7;NRXN1;VLDLR;STMN2;CHP
protein bindingZFAND6;RAB6A;COPG;RUVBL1;TTC30B;FAM164A;NDUFB10;LYAR;FAM103A1
scavenger receptor activityTMPRSS3;MARCO;LGALS3BPA;HHIPL1;TMPRSS4B;SCARF2;TINAG;POLR1B;ENPP2
signaling pattern recognition receptor activityMARCO;TLR2;FCN1;TRIM5;DMBT1;COLEC12;CLEC7A
zymogen binding

DMBT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMBT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMBT1.

CAV1; CDK5RAP3; P/V/C; CDK6; PARD6B

Higashi, K; Asano, K; et al. Expression of the Clustered NeuAc alpha 2-3Gal beta O-Glycan Determines the Cell Differentiation State of the Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 289:25833-25843(2014).
Petersen, CP; Weis, VG; et al. Macrophages Promote Progression of Spasmolytic Polypeptide-Expressing Metaplasia After Acute Loss of Parietal Cells. GASTROENTEROLOGY 146:1727-+(2014).
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Reviews
07/27/2020

    This flexibility allows for tailored approaches and provides researchers with more options to study specific aspects of DMBT1 biology or its interactions with other molecules.

    12/23/2019

      Manufacturers can provide comprehensive product information, including data on the functionality, stability, and handling of DMBT1 protein.

      09/30/2019

        By actively engaging with researchers and understanding their needs, manufacturers can contribute significantly to the success and impact of research involving the DMBT1 protein.

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