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DNASE1

  • Official Full Name

    deoxyribonuclease I

  • Overview

    This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
  • Synonyms

    DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; Deoxyribonuclease 1; Deoxyribonuclease1; DeoxyribonucleaseI; DNASE 1; DNase I lysosomal; DNaseI; DNL 1; DRNI; FLJ38093; Human urine deoxyribonuclease I; DNase I, lysosomal;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Others
  • Bovine
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Bovine
  • CHO
  • CHO Cell
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Pancreas
  • Wheat Germ
  • Fc
  • Fc|His
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNASE1-12094H Recombinant Human DNASE1, GST-tagged E.coli GST 1-282a.a.
Human DNASE1-195H Recombinant Human DNASE1 Mammalian Cell His
Human DNASE1-207H Recombinant Human DNASE1, His tagged Human Cell Fc
Human DNASE1-775H Recombinant Human DNASE1 Protein, GST-His-tagged E.coli GST/His
Human DNASE1-2774H Recombinant Human DNASE1 Protein, GST-tagged Wheat Germ GST
Human DNASE1-1529H Recombinant Human DNASE1 protein, His-tagged E.coli His Gly19~Ala259
Human DNASE1-866HCL Recombinant Human DNASE1 cell lysate Human Cell N/A
Human DNASE1-3522H Recombinant Human DNASE1 protein, His-tagged E.coli His 1-282 aa
Human DNASE1-P001H Recombinant Human DNASE1 therapeutic protein CHO N/A 260 aa
Human DNASE1-2810H Recombinant Human DNASE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DNASE1-10H Recombinant Human DNASE1 protein CHO Cell N/A
Human DNASE1-2810H-B Recombinant Human DNASE1 Protein Pre-coupled Magnetic Beads HEK293
Human DNASE1-4032HF Recombinant Full Length Human DNASE1 Protein, GST-tagged In Vitro Cell Free System GST 282 amino acids
Human DNASE1-1974H Recombinant Human DNASE1 Protein (Gly19-Ala259), His tagged E.coli His Gly19-Ala259
Mouse DNASE1-4726M Recombinant Mouse DNASE1 Protein Mammalian Cell His
Mouse Dnase1-1358M Recombinant Mouse Dnase1 Protein, His-tagged E.coli N-His Leu23-Ile284
Mouse DNASE1-2461M-B Recombinant Mouse DNASE1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DNASE1-2461M Recombinant Mouse DNASE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DNASE1-1917R Recombinant Rat DNASE1 Protein Mammalian Cell His
Rat DNASE1-1576R Recombinant Rat DNASE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DNASE1-1576R-B Recombinant Rat DNASE1 Protein Pre-coupled Magnetic Beads HEK293
Bovine DNASE1-711B Active Recombinant bovine DNASE1 Protein CHO N/A
Bovine DNASE1-1227B Recombinant Bovine Deoxyribonuclease I Bovine N/A
Bovine DNASE1-8333B Native Bovine DNASE1 Pancreas N/A
Bovine DNASE1-0029B Recombinant Bovine DNASE1 Protein (Met1-Thr282), N-His-tagged E.coli N-His Met1-Thr282
Cynomolgus Monkey IL6ST-145C Recombinant Cynomolgus DNASE1, His tagged Human Cell His
Cynomolgus Monkey IL6ST-144C Recombinant Cynomolgus DNASE1, Fc tagged Human Cell Fc/His
Zebrafish DNASE1-781Z Recombinant Zebrafish DNASE1 Mammalian Cell His
Chicken DNASE1-7097C Recombinant Chicken DNASE1 Mammalian Cell His
CMC04 DNase I E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DNASE1 Related Articles

DNASE1 involved in several pathways and played different roles in them. We selected most pathways DNASE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DNASE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DNASE1 has several biochemical functions, for example, actin binding, deoxyribonuclease I activity, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE1 itself. We selected most functions DNASE1 had, and list some proteins which have the same functions with DNASE1. You can find most of the proteins on our site.

Function Related Protein
actin bindingACTR2B;MYO10;SCINLB;MED28;ABLIM3;FHOD1;SHROOM1;MSN;FXYD5
deoxyribonuclease I activityDNASE1;DICER1
endodeoxyribonuclease activityERCC5;DNASE1L3L;DNASE1L1;DNASE1L2;ERCC4;MRE11A;APEX1;DNASE2A;APLF
protein bindingPGLS;CD14;MYL6;SFN;ANGPTL4;SLPI;SERP2;KCNMA1;GORAB

DNASE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNASE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNASE1.

Vogel, B; Frantz, S; et al. Determination of DNase activity by degradation of ethidium bromide-DNA complexes using a fluorescence plate reader. ANALYTICAL BIOCHEMISTRY 471:73-79(2015).
Fragoulis, GE; Vakrakou, AG; et al. Impaired degradation and aberrant phagocytosis of necrotic cell debris in the peripheral blood of patients with primary Sjogren's syndrome. JOURNAL OF AUTOIMMUNITY 56:12-22(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does DNASE1 (Deoxyribonuclease I) contribute to DNA degradation and clearance, particularly in apoptotic cells? 09/21/2022

DNASE1 helps degrade DNA in apoptotic cells, ensuring proper clearance and preventing inflammation.

How does DNASE1 deficiency lead to the development of systemic lupus erythematosus (SLE) and other autoimmune diseases? 02/24/2021

DNASE1 deficiency can contribute to autoimmune diseases like SLE by allowing self-DNA accumulation.

What is the impact of DNASE1 on the regulation of inflammation and immune system activation? 10/22/2020

DNASE1 regulates inflammation and immune responses by controlling extracellular DNA levels.

How does DNASE1 influence the resolution of inflammation and tissue repair processes? 04/21/2020

DNASE1 aids in resolving inflammation and promoting tissue repair by degrading DNA in damaged tissues.

What are the mechanisms by which DNASE1 modulates the stability and integrity of extracellular DNA? 11/09/2019

DNASE1 maintains the stability and integrity of extracellular DNA, preventing inappropriate immune activation.

How do alterations in DNASE1 expression or activity affect susceptibility to chronic inflammatory conditions? 03/06/2019

Changes in DNASE1 function can increase susceptibility to chronic inflammation and autoimmune disorders.

What role does DNASE1 play in preventing the accumulation of self-DNA and autoimmune responses? 11/13/2018

DNASE1 prevents the accumulation of self-DNA, reducing the risk of autoimmune reactions.

Customer Reviews (3)

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Reviews
12/06/2022

    Dependable antibody validation, vital for our immunoprecipitation studies.

    01/10/2022

      Top-quality protein purification service, essential for our lab's work.

      02/22/2019

        Fast and reliable protein expression, a critical part of our projects.

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