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DNASE2

  • Official Full Name

    deoxyribonuclease II, lysosomal

  • Overview

    This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
  • Synonyms

    DNASE2; deoxyribonuclease II, lysosomal; DNL; DNL2; DNASE2A; Deoxyribonuclease-2-alpha; EC=3.1.22.1; Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2; deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha; NP_001366.1; EC 3.1.22.1; Acid DNase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNASE2-2778H Recombinant Human DNASE2 Protein, GST-tagged Wheat Germ GST
Human DNASE2-6863HCL Recombinant Human DNASE2 293 Cell Lysate HEK293 N/A
Human DNASE2-4035HF Recombinant Full Length Human DNASE2 Protein, GST-tagged In Vitro Cell Free System GST 360 amino acids
Human DNASE2-449H Recombinant Human DNASE2 Protein, His-tagged E.coli His Cys19~Ile360
Human DNASE2-776H Recombinant Human DNASE2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DNASE2-698H Recombinant Human DNASE2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DNASE2-971HFL Recombinant Full Length Human DNASE2 Protein, C-Flag-tagged Mammalian cells Flag
Human DNASE2-776H-B Recombinant Human DNASE2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey DNASE2-470C Recombinant Cynomolgus DNASE2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey DNASE2-216C Recombinant Cynomolgus Monkey DNASE2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey DNASE2-216C-B Recombinant Cynomolgus Monkey DNASE2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DNASE2-6475Z Recombinant Zebrafish DNASE2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DNASE2 involved in several pathways and played different roles in them. We selected most pathways DNASE2 participated on our site, such as Clathrin derived vesicle budding, Lysosome, Lysosome Vesicle Biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNASE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Clathrin derived vesicle buddingSNX9;FTH1A;CNO;DTNBP1B;AP1B1;TFR1B;PUM1;CLVS2;AP1G1
LysosomeLIPA;GGA3;ATP6V0D2;CTNS;NAPSA;SLC17A5;GUSB;CTSM;ATP6V0A2
Lysosome Vesicle BiogenesisCLVS1;CLVS2;AP1S3A;DNASE2;CTSZ;AP4B1;BLOC1S1
Membrane TraffickingTRAPPC3;NAPAA;TFR1B;CLINT1;BET1;CLVS1;CTAGE5;ARCN1;CLVS2
Vesicle-mediated transportMYO6B;TPD52L1;PPP6C;GJA5;MYO1C;TERFA;SNX9B;TRAPPC6BL;SNX9A
trans-Golgi Network Vesicle BuddingBLOC1S3;CPD;BLOC1S6;HIP1R;TCEAL4;HIP1RB;PUM1;CLINT1;SNX9A

DNASE2 has several biochemical functions, for example, DNA binding, deoxyribonuclease II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE2 itself. We selected most functions DNASE2 had, and list some proteins which have the same functions with DNASE2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPA2G4;KDM1B;FOXN1;RPS15;NR0B2;ZFP629;YBX2;ZBTB22;ZNF599
deoxyribonuclease II activityDNASE2B;DNASE2A;DNASE2

DNASE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNASE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNASE2.

RUVBL2; RUVBL1; cona_canen

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