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DNM1

  • Official Full Name

    dynamin 1

  • Overview

    This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3 region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    DNM1; dynamin 1; DNM; dynamin-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Yeast
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNM1-06H Recombinant Human DNM1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DNM1-12103H Recombinant Human DNM1, GST-tagged E.coli GST 502-851a.a.
Human DNM1-362H Recombinant Human DNM1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human DNM1-458H Recombinant Human DNM1 Protein (2-245 aa), His-SUMO-tagged E.coli His/SUMO 2-245 aa
Human DNM1-1380H Recombinant Human DNM1 Protein (2-245 aa), His-tagged Yeast His 2-245 aa
Human DNM1-2822H Recombinant Human DNM1 protein, His-tagged E.coli His 2-245aa
Mouse Dnm1-2028M Recombinant Mouse Dnm1 protein, His & T7-tagged E.coli His/T7 Leu572~Ile745 (Accession # P39053)
Mouse DNM1-4735M Recombinant Mouse DNM1 Protein Mammalian Cell His
Mouse Dnm1-2617M Recombinant Mouse Dnm1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DNM1-2469M Recombinant Mouse DNM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DNM1-2469M-B Recombinant Mouse DNM1 Protein Pre-coupled Magnetic Beads HEK293
Rat DNM1-1922R Recombinant Rat DNM1 Protein Mammalian Cell His
Rat DNM1-1581R Recombinant Rat DNM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DNM1-1581R-B Recombinant Rat DNM1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DNM1 Related Articles
  • DNM1 Related Research Area
  • DNM1 Related Signal Pathway

DNM1 involved in several pathways and played different roles in them. We selected most pathways DNM1 participated on our site, such as Adaptive Immune System, Axon guidance, Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemFGF18B;DYNC1I2;FRS2B;FGFR1B;AP1G1;KLRB1B;DYNC1H1;CTSD;KIF15
Axon guidanceCOL4A4;COL9A1;ITGB1;SPTB;RHOAE;NCK1;LRRC4;PPP3CB;CLTB
Bacterial invasion of epithelial cellsCAV1;WASF2;BCAR1;ITGA5;ELMO2;SEPT6;SHC4;CTTN;ARPC5L
CXCR3-mediated signaling eventsMAPKAP1;CXCL13;DNM1
CXCR4-mediated signaling eventsPAG1;ARR3;GNB2L1;GNA13;MAPKAP1;CFL1;CRK;CSK;JAK2
Developmental BiologySMAD3B;EVL;FGFR1B;ACTR2B;JAK1;SEMA3AA;TRPC5;COL9A1;MED31
EGFR1 Signaling PathwaySTXBP1A;PLSCR1;RBBP7;REPS2;APPL2;EEF1A1;PITPNA;PITPNAA;USP6NL
EPH-Ephrin signalingCLTB;EFNB3;EPHB4A;EPHA2A;EPHA10;EFNB2;AP2B1;CLTC;AP2S1

DNM1 has several biochemical functions, for example, GTP binding, GTPase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNM1 itself. We selected most functions DNM1 had, and list some proteins which have the same functions with DNM1. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB11AL;LRRK1;RAB3DA;EHD1A;SEPT10;REM1;ARL8A;GTPBP1L;IRGF1
GTPase activityRAB27B;ARL8B;MXA;GBP4;RAB27A;DNM3;RAB11BB;GSPT1L;ATL1
identical protein bindingNUFIP1;TRA@;SH3GL1;PLN;EPHA4;JMJD6;MCIN;AGER;CSNK2B
poly(A) RNA bindingABT1;RSL1D1;CEBPZ;DHX29;DNAJC2;AGO1;ESF1;C2orf15;GTL3
protein bindingLY96;ZCCHC7;TALDO1;XIRP2;CHD2;PPAP2B;COPS3;PVR;CLOCK
protein dimerization activityMXD3;HES6;NEUROD6B;HER6;ATOH8;AHR2;ATOH1A;ASCL5;NLGN1
protein kinase bindingCCNA2;PTPN23;SHC1;ITGB2;CCNT2B;FOXO3;MLKL;CALM3;CDC25C

DNM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNM1.

GRB2; SNX9; AMPH

Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
Chowdhury, SM; Manepalli, P; et al. Graphene nanoribbons elicit cell specific uptake and delivery via activation of epidermal growth factor receptor enhanced by human papillomavirus E5 protein. ACTA BIOMATERIALIA 10:4494-4504(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does DNM1 contribute to the development and maintenance of neural networks? 03/28/2021

DNM1 contributes to the formation and maintenance of neural circuits, essential for brain function.

What role does DNM1 play in endocytosis and membrane trafficking within cells? 01/03/2021

DNM1 plays a key role in endocytosis, facilitating membrane trafficking and cellular transport processes.

What are the mechanisms by which DNM1 modulates synaptic plasticity and learning? 02/25/2020

DNM1 regulates synaptic plasticity, crucial for learning and memory formation.

How do alterations in DNM1 expression or function affect neurodegenerative diseases? 10/07/2019

Changes in DNM1 function can influence the progression of neurodegenerative diseases, affecting neuronal health and connectivity.

How does DNM1 (Dynamin 1) regulate synaptic vesicle recycling and neurotransmitter release in neurons? 09/17/2019

DNM1 is crucial for synaptic vesicle recycling, controlling neurotransmitter release at synapses.

How does DNM1 influence cellular signaling pathways, particularly in the nervous system? 11/23/2018

DNM1 impacts cellular signaling in neurons, influencing various neuronal activities and responses.

What is the impact of DNM1 mutations on neurological disorders, such as epilepsy? 11/07/2018

Mutations in DNM1 are linked to neurological conditions like epilepsy, affecting synaptic function.

Customer Reviews (3)

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Reviews
09/06/2022

    Precise protein quantification, ensures data accuracy in our experiments.

    05/26/2021

      Accurate mass spectrometry, essential for precise proteomics analysis.

      03/06/2021

        Efficient peptide synthesis, accelerates our peptide research efficiently.

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