DNMT3A
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Official Full Name
DNA (cytosine-5-)-methyltransferase 3 alpha
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Overview
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- StrepII
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DNMT3A Related Articles
- DNMT3A Related Research Area
DNMT3A involved in several pathways and played different roles in them. We selected most pathways DNMT3A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chromatin modifying enzymes | PRMT7;SMARCB1B;ACTL6B;KDM4D;KDM2AA;KDM4A;ATF7IP;ARID5B;HIST2H3C |
Chromatin organization | EP400;DMAP1;MSL2;HMG20B;ING5B;SUZ12A;BRPF1;ING3;ARID2 |
Cysteine and methionine metabolism | GCLM;MAT2A;MDH2;AMD1;ENOPH1;LDHA;BCAT1;GOT1;SMS |
DNA methylation | UHRF1;DNMT3A;DNMT3L;DNMT3B;DNMT1 |
Epigenetic regulation of gene expression | SAP30;SUDS3;DNMT1;SMARCA5;DNMT3L;PHF19;TAF1A;SUZ12B;RBB4L |
Gene Expression | ZNF12;ZNF606;ZNF625;GATAD2A;ZNF684;TYW3;ZNF750;POU2F1;RXRBB |
Metabolic pathways | ADK;SDS;AMPD3;MLYCD;ACOX1;CYP3A7-CYP3AP1;ATP6V1C1A;IDI1;ASAH2 |
MicroRNAs in cancer | TGFB2;PDCD4;MAPK7;EFNA3;THBS1;FGFR3;CCNG1;TTC6;BMPR2 |
DNMT3A has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3A itself. We selected most functions DNMT3A had, and list some proteins which have the same functions with DNMT3A. You can find most of the proteins on our site.
Function | Related Protein |
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DNA (cytosine-5-)-methyltransferase activity | TRDMT1;DNMT3B;DNMT3A;DNMT1 |
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | DNMT3A;DNMT3B |
DNA binding | TIGD1;NKX2;ZBTB7B;BANF1;TNP2;NKX2-5;HOXB8A;ASCL1A;H2AFY |
DNA-methyltransferase activity | PRMT8B;PRDM13;DNMT4;PRDM12;METTL7B;METTL23;PRDM11;DNMT1;METTL21D |
chromatin binding | DNMT1;MORF4L1;ATAD2;POU4F2;PDX1;ZKSCAN3;RBMX;HMGB2B;STAG1 |
identical protein binding | MRFAP1L1;MPZL2B;VIM;FNBP1;SYP;PUF60;SMN2;DYRK1A;APIP |
metal ion binding | NR2F6A;CYP2Y3;KSR2;DZIP1L;GLI4;PDE8B;ENOPH1;DPEP2;PFKMA |
protein binding | CDC6;PRDM5;GAGE8;TOMM34;DYNC1H1;ZDHHC13;TEKT4;MTMR6;HNRNPM |
unmethylated CpG binding | KDM2A;CXXC1;MLL1;DNMT3A;DNMT3B |
DNMT3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3A here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3A.
EZH2; H3F3A; SETDB1
- Q&As
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Q&As (5)
Ask a questionDNMT3A mutations can serve as biomarkers for certain cancers, aiding in the diagnosis and classification of hematologic malignancies.
DNMT3A is essential for normal DNA methylation patterns during development and differentiation, influencing gene expression and cellular function.
Like many targeted therapies, DNMT3A-targeted treatments may have off-target effects, and their specificity is an area of active research.
Yes, molecular diagnostic tests, such as DNA sequencing, can identify DNMT3A mutations in cancer cells.
DNMT3A mutations lead to abnormal DNA methylation patterns, contributing to altered gene expression and promoting cancer development.
Customer Reviews (3)
Write a reviewIts exceptional characteristics, coupled with the manufacturer's commitment to customer satisfaction, ensure that I can pursue my scientific investigations with confidence and success.
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