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DNMT3A

  • Official Full Name

    DNA (cytosine-5-)-methyltransferase 3 alpha

  • Overview

    CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms

    DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Flag
  • GST
  • StrepII
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DNMT3A-164H Active Recombinant Human DNMT3A, GST-tagged Sf9 Insect Cell GST
Human DNMT3A-2790H Recombinant Human DNMT3A Protein, GST-tagged Wheat Germ GST
Human DNMT3A-26885TH Recombinant Human DNMT3A, His-tagged E.coli His
Human DNMT3A-513H Recombinant Human DNMT3A, GST-tagged Insect Cell GST
Human DNMT3A-390H Recombinant Human DNMT3A, His-tagged Insect Cell His
Human DNMT3A-73H Recombinant Human DNM3A protein, GST-tagged Insect Cell GST 2-912
Human DNMT3A-12110H Recombinant Human DNMT3A, GST-tagged E.coli GST 1-280a.a.
Human DNMT3A-6855HCL Recombinant Human DNMT3A 293 Cell Lysate HEK293 N/A
Human DNMT3A-01H Recombinant Human DNMT3A Protein, GST/StrepII-tagged Insect cell GST/StrepII 214-912
Human DNMT3A-20H Recombinant Human DNMT3A, His-tagged E. coli His 680-902aa
Human DNMT3A-01HFL Active Recombinant Full Length Human DNMT3A Protein, Flag-tagged Mamanlian cells Flag
Human DNMT3A-779H Recombinant Human DNMT3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DNMT3A-02HFL Active Recombinant Full Length Human DNMT3A Protein, Flag-tagged Mamanlian cells Flag
Human DNMT3A-779H-B Recombinant Human DNMT3A Protein Pre-coupled Magnetic Beads HEK293
Human DNMT3A-21H Recombinant Human DNMT3A protein, His-tagged E.coli His Ile634~Val912
Human DNMT3A-1978H Recombinant Human DNMT3A Protein (Ala628-Val912), N-His tagged E.coli N-His Ala628-Val912
Human DNMT3A-4049HF Recombinant Full Length Human DNMT3A Protein, GST-tagged In Vitro Cell Free System GST 912 amino acids
Human DNMT3A-1122HFL Recombinant Full Length Human DNMT3A Protein, C-Flag-tagged Mammalian cells Flag
Mouse DNMT3A-4741M Recombinant Mouse DNMT3A Protein Mammalian Cell His
Mouse DNMT3A-2473M Recombinant Mouse DNMT3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DNMT3A-2473M-B Recombinant Mouse DNMT3A Protein Pre-coupled Magnetic Beads HEK293
Mouse Dnmt3a-03MFL Recombinant Full Length Mouse Dnmt3a Protein, Flag-tagged Mamanlian cells Flag
Mouse Dnmt3a-2621M Recombinant Mouse Dnmt3a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat DNMT3A-1926R Recombinant Rat DNMT3A Protein Mammalian Cell His
Rat DNMT3A-1585R-B Recombinant Rat DNMT3A Protein Pre-coupled Magnetic Beads HEK293
Rat DNMT3A-1585R Recombinant Rat DNMT3A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken DNMT3A-2202C Recombinant Chicken DNMT3A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DNMT3A Related Articles
  • DNMT3A Related Research Area

DNMT3A involved in several pathways and played different roles in them. We selected most pathways DNMT3A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Cysteine and methionine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesPRMT7;SMARCB1B;ACTL6B;KDM4D;KDM2AA;KDM4A;ATF7IP;ARID5B;HIST2H3C
Chromatin organizationEP400;DMAP1;MSL2;HMG20B;ING5B;SUZ12A;BRPF1;ING3;ARID2
Cysteine and methionine metabolismGCLM;MAT2A;MDH2;AMD1;ENOPH1;LDHA;BCAT1;GOT1;SMS
DNA methylationUHRF1;DNMT3A;DNMT3L;DNMT3B;DNMT1
Epigenetic regulation of gene expressionSAP30;SUDS3;DNMT1;SMARCA5;DNMT3L;PHF19;TAF1A;SUZ12B;RBB4L
Gene ExpressionZNF12;ZNF606;ZNF625;GATAD2A;ZNF684;TYW3;ZNF750;POU2F1;RXRBB
Metabolic pathwaysADK;SDS;AMPD3;MLYCD;ACOX1;CYP3A7-CYP3AP1;ATP6V1C1A;IDI1;ASAH2
MicroRNAs in cancerTGFB2;PDCD4;MAPK7;EFNA3;THBS1;FGFR3;CCNG1;TTC6;BMPR2

DNMT3A has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3A itself. We selected most functions DNMT3A had, and list some proteins which have the same functions with DNMT3A. You can find most of the proteins on our site.

Function Related Protein
DNA (cytosine-5-)-methyltransferase activityTRDMT1;DNMT3B;DNMT3A;DNMT1
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substratesDNMT3A;DNMT3B
DNA bindingTIGD1;NKX2;ZBTB7B;BANF1;TNP2;NKX2-5;HOXB8A;ASCL1A;H2AFY
DNA-methyltransferase activityPRMT8B;PRDM13;DNMT4;PRDM12;METTL7B;METTL23;PRDM11;DNMT1;METTL21D
chromatin bindingDNMT1;MORF4L1;ATAD2;POU4F2;PDX1;ZKSCAN3;RBMX;HMGB2B;STAG1
identical protein bindingMRFAP1L1;MPZL2B;VIM;FNBP1;SYP;PUF60;SMN2;DYRK1A;APIP
metal ion bindingNR2F6A;CYP2Y3;KSR2;DZIP1L;GLI4;PDE8B;ENOPH1;DPEP2;PFKMA
protein bindingCDC6;PRDM5;GAGE8;TOMM34;DYNC1H1;ZDHHC13;TEKT4;MTMR6;HNRNPM
unmethylated CpG bindingKDM2A;CXXC1;MLL1;DNMT3A;DNMT3B

DNMT3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3A here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3A.

EZH2; H3F3A; SETDB1

Deplus, R; Blanchon, L; et al. Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a. CELL REPORTS 8:743-753(2014).
Ahearne, MJ; Allchin, RL; et al. Follicular helper T-cells: expanding roles in T-cell lymphoma and targets for treatment. BRITISH JOURNAL OF HAEMATOLOGY 166:326-335(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can DNMT3A protein be used as a biomarker for cancer diagnosis? 02/23/2022

DNMT3A mutations can serve as biomarkers for certain cancers, aiding in the diagnosis and classification of hematologic malignancies.

How does DNMT3A impact normal cellular function? 04/15/2021

DNMT3A is essential for normal DNA methylation patterns during development and differentiation, influencing gene expression and cellular function.

Can DNMT3A-targeted therapies have off-target effects? 06/18/2020

Like many targeted therapies, DNMT3A-targeted treatments may have off-target effects, and their specificity is an area of active research.

Are there diagnostic tests for detecting DNMT3A mutations? 05/28/2020

Yes, molecular diagnostic tests, such as DNA sequencing, can identify DNMT3A mutations in cancer cells.

How does DNMT3A contribute to epigenetic changes in cancer cells? 03/03/2020

DNMT3A mutations lead to abnormal DNA methylation patterns, contributing to altered gene expression and promoting cancer development.

Customer Reviews (3)

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Reviews
11/17/2022

    Its exceptional characteristics, coupled with the manufacturer's commitment to customer satisfaction, ensure that I can pursue my scientific investigations with confidence and success.

    09/07/2022

      Its consistent performance and reproducibility have been praised by scientists who have employed it in their studies, with many reporting outstanding results and a high level of satisfaction.

      08/20/2017

        This level of support becomes invaluable, allowing researchers to focus on their scientific objectives while receiving expert guidance alongside.

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