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DOCK1

  • Official Full Name

    dedicator of cytokinesis 1

  • Overview

    DOCK180 and its partner, ELMO1, interact directly with one another to form an atypical two-part guanine nucleotide exchange factor (GEF) for the small GTPase Rac (1). Rac activation occurs in association with p130 Cas and Crk, which form a complex with DO
  • Synonyms

    DOCK1; dedicator of cytokinesis 1; dedicator of cyto kinesis 1; dedicator of cytokinesis protein 1; ced5; DOCK180; DOwnstream of CrK; dedicator of cyto-kinesis 1; 180 kDa protein downstream of CRK;

  • Recombinant Proteins
  • Human
  • Zebrafish
  • E.coli
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK1-2802H Recombinant Human DOCK1 Protein, GST-tagged Wheat Germ GST
Human DOCK1-26153TH Recombinant Human DOCK1 Wheat Germ N/A 152 amino acids
Human DOCK1-26951TH Recombinant Human DOCK1 Wheat Germ N/A 106 amino acids
Human DOCK1-1980H Recombinant Human DOCK1 Protein (Arg443-Cys627), N-His tagged E.coli N-His Arg443-Cys627
Human DOCK1-2543H Recombinant Human DOCK1 protein, His-tagged E.coli His 1565-1865 aa
Human DOCK1-401H Recombinant Human DOCK1 Protein, His-tagged E.coli His Thr1200~Gln1435
Human DOCK1-126HF Recombinant Full Length Human DOCK1 Protein In Vitro Cell Free System 152 amino acids
Human DOCK1-4068HF Recombinant Full Length Human DOCK1 Protein, GST-tagged In Vitro Cell Free System GST 152 amino acids
Zebrafish DOCK1-6085Z Recombinant Zebrafish DOCK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOCK1 Related Articles

DOCK1 involved in several pathways and played different roles in them. We selected most pathways DOCK1 participated on our site, such as Axon guidance, Bacterial invasion of epithelial cells, DCC mediated attractive signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceCNTN1;SEMA6C;COL9A1B;DUSP7;SCN8A;FRS3;ARPC2;Plxna2;SPNA1
Bacterial invasion of epithelial cellsCDH1;BCAR1;ELMO3;SEPT2;SHC1;ARPC4;DNM1;ARPC5L;CTNNA2
DCC mediated attractive signalingNTN1A;TRIO;DOCK1;DCC;NTN1B
Developmental BiologyKBTBD7;SHB;CACNG3;CEBPA;TRPC7;RND1L;SPAG9;NTN1B;EFNA1B
Factors involved in megakaryocyte development and platelet productionKIF2C;HBBE1.1;GATA6;KIF5B;NFE2;GATA1;KIF15;KIF3C;OSTN
Fcgamma receptor (FCGR) dependent phagocytosisARPC1A;ABI1B;ABI1A;PPAPDC1A;WASF2;PPAPDC1B;ABI1;ABI2;PLD4
Focal AdhesionMYL12.1;THBS3;COL2A1A;MYLK4;RAC2;RHOAD;VWF;PRKCBB;ACTN4

DOCK1 has several biochemical functions, for example, GTPase activator activity, SH3 domain binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK1 itself. We selected most functions DOCK1 had, and list some proteins which have the same functions with DOCK1. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityTBC1D26;RGS5;ALS2CL;GAPVD1;NF1;ARFGAP2;RAP1GDS1;ADAP2;RASAL2
SH3 domain bindingMICAL1;GRB2;ABL1;ITGB1BP2;ELMO2;PDE4D;ADAM17;SH2D2A;SH3BP1
guanyl-nucleotide exchange factor activityPTGIR;RAPGEF6;SH2D3C;RAPGEFL1;ARHGEF39;FGD2;SH2D3CB;FGD4;NET1
protein bindingTTLL6;TRIM13;VAV3;NUPL1;PTPRB;KRAS;WDHD1;GAGE8;ELK4

DOCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK1.

ELMO1; RAC1

Abu-Thuraia, A; Gauthier, R; et al. Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion. MOLECULAR AND CELLULAR BIOLOGY 35:76-87(2015).
Epting, D; Slanchev, K; et al. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. DEVELOPMENT 142:174-184(2015).
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