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DOCK10

  • Official Full Name

    dedicator of cytokinesis 10

  • Overview

    Dock10 (Dedicator of cytokinesis), also known as Zizimin3, is a large (~240 kDa) protein involved in intracellular signalling networks.It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins.
  • Synonyms

    DOCK10; dedicator of cytokinesis 10; dedicator of cytokinesis protein 10; KIAA0694; ZIZ3; zizimin3; zizimin-3; protein zizimin 3; dopamine receptor interacting protein 2; DRIP2; Nbla10300; DKFZp781A1532;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK10-2804H Recombinant Human DOCK10 Protein, GST-tagged Wheat Germ GST
Human DOCK10-12117H Recombinant Human DOCK10, His-tagged E.coli His 194-542a.a.
Human DOCK10-1365H Recombinant Human DOCK10 Protein, His-tagged E.coli N-His Ala1945-Val2186
Human DOCK10-4070HF Recombinant Full Length Human DOCK10 Protein, GST-tagged In Vitro Cell Free System GST 542 amino acids
Mouse Dock10-1366M Recombinant Mouse Dock10 Protein, His-tagged E.coli N-His Ile2016-Val2187
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DOCK10 involved in several pathways and played different roles in them. We selected most pathways DOCK10 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Factors involved in megakaryocyte development and platelet productionKLC3;KIF2C;GATA2A;MYB;HBB-BH1;PHF21A;IRF1B;KIF2B;DOCK11
HemostasisCEACAM8;BRPF3;GRB7;HMG20B;CEACAM6;APOA1B;KLC3;ANXA2B;DOCK7
Regulation of CDC42 activityBCAR3;ARHGAP1;ARHGAP17;DOCK6;DOCK10;DNMBP;DOCK9;SPATA13;ITSN2

DOCK10 has several biochemical functions, for example, Rho GTPase binding, Rho guanyl-nucleotide exchange factor activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK10 itself. We selected most functions DOCK10 had, and list some proteins which have the same functions with DOCK10. You can find most of the proteins on our site.

Function Related Protein
Rho GTPase bindingPARD6A;DOCK9;FLNA;DAPK3;DAAM1;KIF3B;PFN1;CDC42BPB;IQGAP3
Rho guanyl-nucleotide exchange factor activityC3A.1;RASGRF2;VAV2;DOCK11;TIAM2;ARHGEF18A;DOCK9;SOS1;ARHGEF15
molecular_functionWDR55;TMEM239;SKINT6;PPP1R27B;NEURL4;FAM81A;CCDC114;LEPROTL1;XKR8
protein bindingSPTLC1;PMAIP1;ZNF155;WRNIP1;AHSA2;ANLN;RGS3;C11orf54;CEP164

DOCK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK10.

LURAP1

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