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DOCK4

  • Official Full Name

    dedicator of cytokinesis 4

  • Overview

    This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.
  • Synonyms

    DOCK4; dedicator of cytokinesis 4; dedicator of cytokinesis protein 4; FLJ34238; KIAA0716; MGC134911; MGC134912;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK4-12119H Recombinant Human DOCK4, GST-tagged E.coli GST C-term-310a.a.
Human DOCK4-2806H Recombinant Human DOCK4 Protein, GST-tagged Wheat Germ GST
Human DOCK4-403H Recombinant Human DOCK4 Protein, His/GST-tagged E.coli His/GST Met1~Pro300
Human DOCK4-2283H Recombinant Human DOCK4 Protein (Met1-Pro300), N-His tagged E.coli N-His Met1-Pro300
Human DOCK4-3468H Recombinant Human DOCK4 protein, His-tagged E.coli His 1838-1971 aa
Mouse DOCK4-4754M Recombinant Mouse DOCK4 Protein Mammalian Cell His
Mouse DOCK4-2479M-B Recombinant Mouse DOCK4 Protein Pre-coupled Magnetic Beads HEK293
Mouse DOCK4-2479M Recombinant Mouse DOCK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DOCK4 involved in several pathways and played different roles in them. We selected most pathways DOCK4 participated on our site, such as Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayFGF12;Kitl;ANGPT4;PDGFRA;CDH1;ACTB;ITGA2B;TLN1;PDGFB

DOCK4 has several biochemical functions, for example, GTPase activator activity, PDZ domain binding, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK4 itself. We selected most functions DOCK4 had, and list some proteins which have the same functions with DOCK4. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityDOCK1;ARAP2;TBC1D10B;BCR;TBC1D22B;ARHGAP9;RANGAP1A;ERRFI1;DLC1
PDZ domain bindingATP2B4;SLC22A12;SNTA1;LLGL2;LIN7B;GRIK5;SDC2;KCNJ4;CRIPT
Rac GTPase bindingSRGAP1;NOX1;ITPKA;ARHGAP4;RCC2;NCF2;PAK7;RALBP1;FMNL1
SH3 domain bindingGRB2;ENKUR;CD2AP;ARHGAP17;SKAP1;SH3BGR;MAPT;LYN;RAD9A
guanyl-nucleotide exchange factor activityDENND6A;TIAM2;GCGR;RANGRF;CHRM4;ITSN2A;VAV3B;RASGRF2B;RASGRP1
protein bindingRABGAP1;PPP6C;DPH1;NPHP3;CCNG1;CTAGE5;BLOC1S6;TXNDC16;ICAM1
receptor tyrosine kinase bindingPTPN11;LRP4;PTPN14;ZNF259;TRP53;DNAJA3;NRG3;GNB2L1;ANXA5

DOCK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK4.

GRB2; FASLG; HNRNPL; YWHAB

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