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DOCK6

  • Official Full Name

    DOCK6 dedicator of cytokinesis 6 [ Homo sapiens ]

  • Overview

    This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2.
  • Synonyms

    dedicator of cytokinesis 6; Ensembl:ENSRNOG00000010652; dedicator of cytokinesis protein 6;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK6-12121H Recombinant Human DOCK6, His-tagged E.coli His 1699-2041a.a.
Mouse Dock6-1369M Recombinant Mouse Dock6 Protein, His-tagged E.coli N-His Phe1915-Leu2080
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DOCK6 involved in several pathways and played different roles in them. We selected most pathways DOCK6 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Factors involved in megakaryocyte development and platelet productionPHF21A;HBBE3;KIF9;DOCK2;DOCK7;OSTN;KIF3A;AKAP10;KIF11
HemostasisSTXBP3A;HMG20B;DGKB;GLG1B;LRRC16A;CD9A;KIF26A;ITPK1;HBBE2
Regulation of CDC42 activitySPATA13;ARHGAP1;RALBP1;DOCK6;DOCK9;ARHGAP17;ARHGEF25;DNMBP;BCAR3
Regulation of RAC1 activityRALBP1;DOCK6;DEF6;RAP1GDS1;ARHGAP1;ABR;ARHGAP9;CHN1;PREX2

DOCK6 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK6 itself. We selected most functions DOCK6 had, and list some proteins which have the same functions with DOCK6. You can find most of the proteins on our site.

Function Related Protein
guanyl-nucleotide exchange factor activitySBF1;VAV1;FGD2;VAV3;ITSN2A;RIC8;ARHGEF11;ARHGEF39;PTGIR

DOCK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK6.

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