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DOCK7

  • Official Full Name

    dedicator of cytokinesis 7

  • Overview

    Dock7 (Dedicator of cytokinesis 7), also known as Zir2, is a large (~240 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock7 activates isoforms of the small G protein Rac.
  • Synonyms

    DOCK7; dedicator of cytokinesis 7; ZIR2; KIAA1771, ZIR2; OTTHUMP00000015338; dedicator of cytokinesis protein 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Rat
  • E.coli
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOCK7-28082TH Recombinant Human DOCK7, His-tagged E.coli His
Human DOCK7-2808H Recombinant Human DOCK7 Protein, GST-tagged Wheat Germ GST
Human DOCK7-504HCL Recombinant Human DOCK7 cell lysate N/A
Human DOCK7-3936HF Recombinant Full Length Human DOCK7 Protein, GST-tagged In Vitro Cell Free System GST 624 amino acids
Human DOCK7-1370H Recombinant Human DOCK7 Protein, His-tagged E.coli N-His Val1916-Leu2140
Rat Dock7-1371R Recombinant Rat Dock7 Protein, His-tagged E.coli N-His Arg1815-Leu2118
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOCK7 Related Articles

DOCK7 involved in several pathways and played different roles in them. We selected most pathways DOCK7 participated on our site, such as ErbB2/ErbB3 signaling events, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB2/ErbB3 signaling eventsCHRNA1;FMNL3;DOCK7;CHRNE;RNF41
Factors involved in megakaryocyte development and platelet productionDOCK2;KIF11;HMG20B;PHF21A;ZFPM2A;GATA1;KIF2A;MFN1;HBB-Y
HemostasisITPK1;CLEC1B;MFN2;IRF2A;CENPE;F13A1A.1;KIF26A;AKAP1;HBE1

DOCK7 has several biochemical functions, for example, Rac GTPase binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK7 itself. We selected most functions DOCK7 had, and list some proteins which have the same functions with DOCK7. You can find most of the proteins on our site.

Function Related Protein
Rac GTPase bindingPKN1;SRGAP1;DOCK7;RAB7;RCC2;PAK6;RAB7A;SRGAP2B;CORO1C
guanyl-nucleotide exchange factor activityDOCK1;DOCK5;RPGR;RIC8B;DENND4B;PTGIR;FGD1;RASGRP3;PRSS56

DOCK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK7.

USP19; YWHAG; USP7; RPP14; TK1; ANXA7; SNCA; CDKN1A; PPP2CB; BCL2L1; GRB7; SMN1; WHSC1L1; q9wmx2-pro_0000037548; RASSF10; N; LRCH4; MYC; YWHAZ; YWHAH

Schaker, K; Bartsch, S; et al. The Bipartite Rac1 Guanine Nucleotide Exchange Factor Engulfment and Cell Motility 1/Dedicator of Cytokinesis 180 (Elmo1/Dock180) Protects Endothelial Cells from Apoptosis in Blood Vessel Development. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6408-6418(2015).
Aydin, SE; Kilic, SS; et al. DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients. JOURNAL OF CLINICAL IMMUNOLOGY 35:189-198(2015).
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