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DOK1

  • Official Full Name

    docking protein 1, 62kDa (downstream of tyrosine kinase 1)

  • Overview

    The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
  • Synonyms

    DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1); P62DOK; docking protein 1; pp62; p62(dok); Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Antibody
  • Human
  • Mouse
  • Rat
  • E.coli
  • Guinea Pig
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOK1-619H Recombinant Human DOK1 Mammalian Cell His
Human DOK1-28084TH Recombinant Human DOK1 Wheat Germ N/A 481 amino acids
Human DOK1-6848HCL Recombinant Human DOK1 293 Cell Lysate HEK293 N/A
Human DOK1-2813H Recombinant Human DOK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DOK1-1375H Recombinant Human DOK1 Protein, His-tagged E.coli N-His Gly18-Gln237
Human DOK1-2813H-B Recombinant Human DOK1 Protein Pre-coupled Magnetic Beads HEK293
Human DOK1-1110H Recombinant Human DOK1 Protein (1-481 aa), His-SUMO-tagged E.coli His/SUMO 1-481 aa
Human DOK1-129HF Recombinant Full Length Human DOK1 Protein In Vitro Cell Free System 481 amino acids
Human DOK1-2125H Recombinant Human DOK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Dok1-2629M Recombinant Mouse Dok1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DPABT-H17728 Guinea Pig Anti-DOK1 Polyclonal Antibody Guinea Pig N/A
Rat DOK1-1931R Recombinant Rat DOK1 Protein Mammalian Cell His
Rat Dok1-676R Recombinant Rat Dok1 Protein, His-tagged E.coli His Gly18~Gln237
Rat DOK1-1590R Recombinant Rat DOK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DOK1-1590R-B Recombinant Rat DOK1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOK1 Related Articles

DOK1 involved in several pathways and played different roles in them. We selected most pathways DOK1 participated on our site, such as B Cell Receptor Signaling Pathway, BCR signaling pathway, Fc-epsilon receptor I signaling in mast cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B Cell Receptor Signaling PathwayPPP3CC;PILRB;DUSP6;DOK1;CTNNB2;PTPN6;FCGR2B;PIK3CG;RASGRP3
BCR signaling pathwayDOK1;MALT1;POU2F2;CSK;NETO2;PAG1;CSNK2A1;MAP4K1;IBTK
Fc-epsilon receptor I signaling in mast cellsPTPN13;DOK1;ITK;LAT2;S1PR1
Insulin PathwayEXOC5;DOK1;GRB14;EXOC3;GRB10;EXOC6;EXOC1
Kit Receptor Signaling PathwayDOK1B;PTPRU;SPRED2B;GRAPA;GRB10;SOCS4;DOK1;GRAP;GRB7
MeaslesPIK3CD;HSPA2;EIF3H;STAT5B;TLR2;IL2RG;HSPA1B;CCNE2;Ifna11
PDGFR-beta signaling pathwayDOK1;GRB10;SNX15;SLC9A3R1;SLA
Signaling events mediated by PTP1BNOX4;YBX1;DOK1;CSN2

DOK1 has several biochemical functions, for example, insulin receptor binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK1 itself. We selected most functions DOK1 had, and list some proteins which have the same functions with DOK1. You can find most of the proteins on our site.

Function Related Protein
insulin receptor bindingDOK3;DOK2;SNX2;IRS4;IGF1;PTPN11;IGF1R;INSL3;DOK6
protein bindingAUP1;GPR143;CSRNP1;FKBP8;GTF2E1;AK3;NHP2;IL5RA;CRHBP
receptor signaling protein activityCD19;FLRT3;FCGR1A;KLK1B4;BAG1;NGF;DOK4;IL1RL1;PDCL

DOK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK1.

SRMS; Cbll1; ORF; CRKL; DOK3; SH2D1A; ERBB2; Dlg4

Kanehara, K; Cho, Y; et al. Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction. PLANT JOURNAL 81:292-303(2015).
Mukherjee, M; Jing-Song, F; et al. Dimeric Switch of Hakai-truncated Monomers during Substrate Recognition INSIGHTS FROM SOLUTION STUDIES AND NMR STRUCTURE. JOURNAL OF BIOLOGICAL CHEMISTRY 289:25611-25623(2014).
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