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DOK2

  • Official Full Name

    docking protein 2, 56kDa

  • Overview

    Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. DOK-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. DOK-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung.
  • Synonyms

    DOK2; docking protein 2, 56kDa; docking protein 2, 56kD; docking protein 2; Dok 2; p56dok 2; p56(dok-2); downstream of tyrosine kinase 2; p56DOK; p56dok-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOK2-28083TH Recombinant Human DOK2, His-tagged E.coli His
Human DOK2-2810H Recombinant Human DOK2 Protein, GST-tagged Wheat Germ GST
Human DOK2-6847HCL Recombinant Human DOK2 293 Cell Lysate HEK293 N/A
Human DOK2-3938HF Recombinant Full Length Human DOK2 Protein, GST-tagged In Vitro Cell Free System GST 412 amino acids
Human DOK2-1233H Recombinant Human DOK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse DOK2-4761M Recombinant Mouse DOK2 Protein Mammalian Cell His
Mouse Dok2-2630M Recombinant Mouse Dok2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DOK2-2483M-B Recombinant Mouse DOK2 Protein Pre-coupled Magnetic Beads HEK293
Mouse DOK2-2483M Recombinant Mouse DOK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DOK2 involved in several pathways and played different roles in them. We selected most pathways DOK2 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Angiopoietin receptor Tie2-mediated signalingELF2;ELF1;GRB7;CRK;GRB14;AGTR1;CDKN1A;DOK2;BMX
Cell surface interactions at the vascular wallANGPT2A;TREM1;GAS6;CD84;MERTK;ESAMA;BSG;CXADR;FN1B
EGFR1 Signaling PathwayGRB7;PITPNA;TNK2;AP2A1;RBBP7;SPRY2;EPPK1;GRB14;REPS1
HemostasisCEACAM1;TRPC3;ATP2B3A;PLEK;IRF1B;CENPE;PROCA;DGKQ;KIF5B
IL-4 signaling PathwayADRBK2;SPI1B;DOK2;HMGA1-RS1;PAWR;IL4R.1
IL2-mediated signaling eventsIKZF3;DOK2;STAM2;CISH
IL4-mediated signaling eventsMYBL1;PARP14;DOK2;NIPAL1;RETNLB;MYB;EGR2;IgG3;TFF3
Tie2 SignalingDOK2;ANGPT2A;GRB14

DOK2 has several biochemical functions, for example, insulin receptor binding, protein binding, receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK2 itself. We selected most functions DOK2 had, and list some proteins which have the same functions with DOK2. You can find most of the proteins on our site.

Function Related Protein
insulin receptor bindingDOK5;IGF2;IGF1;INS2;LMBRD1;INS1;DOK6;DOK1B;PIK3R1
protein bindingTOMM34;KCNMA1;PPP2R1A;GCG;PPARA;USP28;CXCL11;FAM124B;KLF2
receptor signaling protein activityNCR1;IL4R;ARF1;CD19;ADCYAP1;RGS14A;SMAD1;Siglece;FCGR1A
transmembrane receptor protein tyrosine kinase adaptor activitySH2B2;SHC1;TRAT1;GAB2;PIK3R1;STAP1;IRS1;BLNK;DOK2

DOK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK2.

POT1; LCK; STAT3; CRK; CRK; CRKL; DOK3; APPL1; CFLAR; SPOP; SSSCA1

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