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DOK7

  • Official Full Name

    docking protein 7

  • Overview

    The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
  • Synonyms

    DOK7; docking protein 7; CMS1B; C4orf25; protein Dok-7; downstream of tyrosine kinase 7;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOK7-2816H Recombinant Human DOK7 Protein, GST-tagged Wheat Germ GST
Human DOK7-6843HCL Recombinant Human DOK7 293 Cell Lysate HEK293 N/A
Human DOK7-3767H Recombinant Human DOK7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DOK7-3946HF Recombinant Full Length Human DOK7 Protein, GST-tagged In Vitro Cell Free System GST 298 amino acids
Mouse DOK7-4766M Recombinant Mouse DOK7 Protein Mammalian Cell His
Mouse Dok7-2632M Recombinant Mouse Dok7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DOK7-2487M Recombinant Mouse DOK7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DOK7-2487M-B Recombinant Mouse DOK7 Protein Pre-coupled Magnetic Beads HEK293
Rat Dok7-205R Recombinant Rat Dok7 Protein, His-tagged E.coli His Trp63~Gly320
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOK7 Related Articles
  • DOK7 Related Research Area

DOK7 involved in several pathways and played different roles in them. We selected most pathways DOK7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DOK7 has several biochemical functions, for example, insulin receptor binding, lipid binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK7 itself. We selected most functions DOK7 had, and list some proteins which have the same functions with DOK7. You can find most of the proteins on our site.

Function Related Protein
insulin receptor bindingPTPN11;SHC1;SNX1;LMBRD1;FRS2B;IGF2;FRS3;SLC2A2;DOK2
lipid bindingAPOA4B.1;FABP10A;ACBD6;BPIFB1;UNC119;FABP1A;BAD;UNC119B;CYTH4
protein kinase bindingPTPRR;PTPRJ;DNM1;SMAD3;PLK1;USP37;TRAP1;CCNYL1;AP1B1

DOK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK7.

mpzl1; CRK; APPL1; ypel3; EFHC1; GABARAPL2

Witting, N; Crone, C; et al. Clinical and neurophysiological response to pharmacological treatment of DOK7 congenital myasthenia in an older patient. CLINICAL NEUROLOGY AND NEUROSURGERY 130:168-170(2015).
Franco, A; Malhotra, N; et al. Publication bias in the social sciences: Unlocking the file drawer. SCIENCE 345:1502-1505(2014).
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