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DOLK

  • Official Full Name

    dolichol kinase

  • Overview

    The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.
  • Synonyms

    DOLK; dolichol kinase; TMEM15, transmembrane protein 15; DK1; dolichol kinase 1; KIAA1094; CDG1M; DK; SEC59; SEC59, YEAST, HOMOLOG OF; TMEM15; Transmembrane protein 15; SEC59 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOLK-2817H Recombinant Human DOLK Protein Wheat Germ N/A
Human DOLK-6842HCL Recombinant Human DOLK 293 Cell Lysate HEK293 N/A
Human DOLK-3947HF Recombinant Full Length Human DOLK Protein In Vitro Cell Free System 289 amino acids
Mouse DOLK-4767M Recombinant Mouse DOLK Protein Mammalian Cell His
Mouse DOLK-2488M Recombinant Mouse DOLK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DOLK-2488M-B Recombinant Mouse DOLK Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DOLK-1314R Recombinant Rhesus monkey DOLK Protein, His-tagged Mammalian Cell His
Rhesus Macaque DOLK-1139R Recombinant Rhesus Macaque DOLK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DOLK-1139R-B Recombinant Rhesus Macaque DOLK Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DOLK-6201Z Recombinant Zebrafish DOLK Mammalian Cell His
Chicken DOLK-5037C Recombinant Chicken DOLK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOLK Related Articles

DOLK involved in several pathways and played different roles in them. We selected most pathways DOLK participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOLK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
N-Glycan biosynthesisMAN1B1;DPM1;GANAB;DPM2;RPN1;MAN2A2;ALG3;ALG14;B4GALT1
Metabolic pathwaysATP6V1E1;GMPPB;TST;SHMT2;HADHA;SMPD4;ASPA;INPP5J;ALDH3A2A

DOLK has several biochemical functions, for example, dolichol kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOLK itself. We selected most functions DOLK had, and list some proteins which have the same functions with DOLK. You can find most of the proteins on our site.

Function Related Protein
dolichol kinase activity
protein bindingMYBPC3;KLHL41;TMEM123;CRYBB3;ZBTB6;OPRL1;NME4;TRIM50;RYBP

DOLK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOLK here. Most of them are supplied by our site. Hope this information will be useful for your research of DOLK.

EDA; CREB3

Voss, S; Dolk, DR; et al. Interview with Daniel Dolk and Christer Carlsson on "Decision Analytics". BUSINESS & INFORMATION SYSTEMS ENGINEERING 6:181-184(2014).
Lieu, MT; Ng, BG; et al. Severe, fatal multisystem manifestations in a patient with dolichol kinase-congenital disorder of glycosylation. MOLECULAR GENETICS AND METABOLISM 110:484-489(2013).
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