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DOT1L

  • Official Full Name

    DOT1-like histone H3K79 methyltransferase

  • Overview

    The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
  • Synonyms

    DOT1L; DOT1-like histone H3K79 methyltransferase; DOT1; KMT4; histone-lysine N-methyltransferase, H3 lysine-79 specific; H3-K79-HMTase; DOT1-like protein; lysine N-methyltransferase 4; histone methyltransferase DOT1L; histone H3-K79 methyltransferase; DOT1-like, histone H3 methyltransferase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DOT1L-180H Active Recombinant Human DOT1L protein, GST-tagged Insect Cell GST 1-435 aa
Human DOT1L-2821H Recombinant Human DOT1L Protein, GST-tagged Wheat Germ GST
Human DOT1L-658H Recombinant Human DOT1L, GST-tagged E.coli GST
Human DOT1L-27742TH Recombinant Human DOT1L E.coli N/A
Human DOT1L-767H Recombinant Human DOT1L protein E.coli N/A Gly2-Lys416
Human DOT1L-6841HCL Recombinant Human DOT1L 293 Cell Lysate HEK293 N/A
Human DOT1L-006H Recombinant Human DOT1L Protein, GST-tagged E.coli GST 2-416
Human DOT1L-2979H Recombinant Human DOT1L protein, His-tagged E.coli His 511-698 aa
Human DOT1L21203H Recombinant Human Dot1L (1-351) Protein
Human DOT1L3226H Recombinant Human Dot1L (1-416) Protein
Human DOT1L-130H Recombinant Human DOT1L Protein, GST-tagged E. coli GST 2-416
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DOT1L Related Research Area

DOT1L involved in several pathways and played different roles in them. We selected most pathways DOT1L participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOT1L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lysine degradationHYKK;DOT1L;BBOX1;SUV420H1;ALDH3A2A;EHMT2;PIPOX;SUV39H1;ALDH3A2
Transcriptional misregulation in cancerTLX1;PER2;FUS;HHEX;Pdgfa&Pdgfb;LYL1;HIST1H3D;NFKBIZ;PAX7

DOT1L has several biochemical functions, for example, DNA binding, histone methyltransferase activity (H3-K79 specific), histone-lysine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOT1L itself. We selected most functions DOT1L had, and list some proteins which have the same functions with DOT1L. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCDK5R2;PUF60;HOXD3;ALX4B;ZNF738;HOXC13A;HIST1H4H;ZNF521;FOXA
histone methyltransferase activity (H3-K79 specific)
histone-lysine N-methyltransferase activityEHMT1A;DOT1L;SUV420H1;SETD8A;AAAS;SUV39H1A;SETD1BA;SMYD1;SMYD2B
protein bindingRBM42;MYCN;BICD1;ETV1;FCGR1A;PSMD14;NRIP3;HOXB5;ESRP1
transcription factor bindingKDM1A;DIP2A;KCTD1;PELP1;HES1;EGR1;TRERF1;APBB3;GTF2B

DOT1L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOT1L here. Most of them are supplied by our site. Hope this information will be useful for your research of DOT1L.

MLLT3; MLLT1; MLLT10; MLLT6; HIST2H3D

  • Q&As
  • Reviews

Q&As (7)

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What are the mechanisms by which DOT1L modulates transcriptional regulation in various cell types? 06/04/2021

DOT1L modulates transcriptional regulation, affecting gene expression patterns in different cell types.

How do alterations in DOT1L expression or activity affect cellular aging and the development of age-related diseases? 04/28/2021

Variations in DOT1L activity impact cellular aging and may contribute to age-related diseases.

How does DOT1L influence embryonic development and stem cell differentiation? 10/10/2020

DOT1L influences embryonic development and stem cell differentiation through epigenetic regulation.

How does DOT1L contribute to the pathogenesis of leukemia, particularly MLL-rearranged leukemia? 06/16/2019

DOT1L contributes to leukemia development, especially in MLL-rearranged cases, by altering gene expression.

How does DOT1L (Disruptor of Telomeric Silencing 1-Like) regulate histone methylation and gene expression? 03/13/2019

DOT1L regulates gene expression by methylating histone H3, affecting chromatin and gene activity.

What role does DOT1L play in the development and maintenance of chromatin structure? 11/06/2018

DOT1L plays a crucial role in chromatin structure and stability, influencing genomic integrity.

What is the impact of DOT1L inhibition on epigenetic therapies for cancer treatment? 02/08/2018

Inhibiting DOT1L shows promise in epigenetic cancer therapies by modifying disease-related gene expression.

Customer Reviews (3)

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Reviews
11/04/2022

    Efficient protein purification, consistently delivers high yield and purity.

    11/21/2020

      Precise protein quantification, ensures data precision in our experiments.

      02/11/2018

        Dependable peptide synthesis, accelerates our peptide-focused projects effectively.

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