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DPAGT1

  • Official Full Name

    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)

  • Overview

    The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme.
  • Synonyms

    DPAGT1; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); DPAGT, DPAGT2; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; ALG7; CDG Ij; D11S366; DGPT; GPT; Gnpta; H2afx; AU021132; Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase); DPAGT2; G1PT; GlcNAc-1-P transferase; GPT_HUMAN; N-acetylglucosamine-1-phosphate transferase; OTTHUMP00000204052; OTTHUMP00000204055; dolichyl-phosphate alpha-N-acetylglucosaminyltransferase; UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra; UAGT; UGAT; CDG1J; DPAGT; CDG-Ij;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DPAGT1-2822H Recombinant Human DPAGT1 Protein, GST-tagged Wheat Germ GST
Human DPAGT1-6840HCL Recombinant Human DPAGT1 293 Cell Lysate HEK293 N/A
Mouse DPAGT1-4776M Recombinant Mouse DPAGT1 Protein Mammalian Cell His
Mouse DPAGT1-2492M-B Recombinant Mouse DPAGT1 Protein Pre-coupled Magnetic Beads HEK293
Mouse DPAGT1-2492M Recombinant Mouse DPAGT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DPAGT1-1316R Recombinant Rhesus monkey DPAGT1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DPAGT1-1141R-B Recombinant Rhesus Macaque DPAGT1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DPAGT1-1141R Recombinant Rhesus Macaque DPAGT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish DPAGT1-5545Z Recombinant Zebrafish DPAGT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DPAGT1 involved in several pathways and played different roles in them. We selected most pathways DPAGT1 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPAGT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Asparagine N-linked glycosylationNANP;PPP6R3;STT3A;ST6GALNAC1.2;NAPAA;ST8SIA2;TRAPPC10;NEU3;NAPG
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinMPDU1B;SLC35A1;MPDU1;ALG10B;NEU3;ALG2;MPDU1A;NANP;NEU4
Metabolic pathwaysTH;CYP4A12A;GLYCTK;CRLS1;TKTL1;MT-ND4;PISD;GCNT4A;B4GALT4
Metabolism of proteinsIGFALS;ADAMTSL3;CST3;DNAJB9;THSD1;LMAN2;SEC23IP;PAPPA;CTAGE5
N-Glycan biosynthesisFUT8;DOLK;B4GALT1;RPN2;DPAGT1;ALG12;MAN1A1;MAN1A;DPM1
Post-translational protein modificationTMED10;ADAMTS1;TRAPPC5;ADAMTS13;DPH5;SMC6;DAD1;DPH2;MUC1
dolichyl-diphosphooligosaccharide biosynthesis

DPAGT1 has several biochemical functions, for example, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity, phospho-N-acetylmuramoyl-pentapeptide-transferase activity, transferase activity, transferring glycosyl groups. Some of the functions are cooperated with other proteins, some of the functions could acted by DPAGT1 itself. We selected most functions DPAGT1 had, and list some proteins which have the same functions with DPAGT1. You can find most of the proteins on our site.

Function Related Protein
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
phospho-N-acetylmuramoyl-pentapeptide-transferase activity
transferase activity, transferring glycosyl groupsST3GAL3B;B3GNT8;B3GNT2B;FUT9D;UGGT1;GLT8D1;4931440L10Rik;UGT2B3;GXYLT1

DPAGT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPAGT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPAGT1.

MFSD3

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