DPAGT1
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Official Full Name
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
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Overview
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. -
Synonyms
DPAGT1; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); DPAGT, DPAGT2; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; ALG7; CDG Ij; D11S366; DGPT; GPT; Gnpta; H2afx; AU021132; Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase); DPAGT2; G1PT; GlcNAc-1-P transferase; GPT_HUMAN; N-acetylglucosamine-1-phosphate transferase; OTTHUMP00000204052; OTTHUMP00000204055; dolichyl-phosphate alpha-N-acetylglucosaminyltransferase; UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra; UAGT; UGAT; CDG1J; DPAGT; CDG-Ij;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | DPAGT1-2822H | Recombinant Human DPAGT1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | DPAGT1-6840HCL | Recombinant Human DPAGT1 293 Cell Lysate | HEK293 | N/A | ||
Mouse | DPAGT1-4776M | Recombinant Mouse DPAGT1 Protein | Mammalian Cell | His | ||
Mouse | DPAGT1-2492M-B | Recombinant Mouse DPAGT1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | DPAGT1-2492M | Recombinant Mouse DPAGT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | DPAGT1-1316R | Recombinant Rhesus monkey DPAGT1 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | DPAGT1-1141R-B | Recombinant Rhesus Macaque DPAGT1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | DPAGT1-1141R | Recombinant Rhesus Macaque DPAGT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | DPAGT1-5545Z | Recombinant Zebrafish DPAGT1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
DPAGT1 involved in several pathways and played different roles in them. We selected most pathways DPAGT1 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPAGT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Asparagine N-linked glycosylation | NANP;PPP6R3;STT3A;ST6GALNAC1.2;NAPAA;ST8SIA2;TRAPPC10;NEU3;NAPG |
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | MPDU1B;SLC35A1;MPDU1;ALG10B;NEU3;ALG2;MPDU1A;NANP;NEU4 |
Metabolic pathways | TH;CYP4A12A;GLYCTK;CRLS1;TKTL1;MT-ND4;PISD;GCNT4A;B4GALT4 |
Metabolism of proteins | IGFALS;ADAMTSL3;CST3;DNAJB9;THSD1;LMAN2;SEC23IP;PAPPA;CTAGE5 |
N-Glycan biosynthesis | FUT8;DOLK;B4GALT1;RPN2;DPAGT1;ALG12;MAN1A1;MAN1A;DPM1 |
Post-translational protein modification | TMED10;ADAMTS1;TRAPPC5;ADAMTS13;DPH5;SMC6;DAD1;DPH2;MUC1 |
dolichyl-diphosphooligosaccharide biosynthesis |
DPAGT1 has several biochemical functions, for example, UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity, phospho-N-acetylmuramoyl-pentapeptide-transferase activity, transferase activity, transferring glycosyl groups. Some of the functions are cooperated with other proteins, some of the functions could acted by DPAGT1 itself. We selected most functions DPAGT1 had, and list some proteins which have the same functions with DPAGT1. You can find most of the proteins on our site.
Function | Related Protein |
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UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity | |
phospho-N-acetylmuramoyl-pentapeptide-transferase activity | |
transferase activity, transferring glycosyl groups | ST3GAL3B;B3GNT8;B3GNT2B;FUT9D;UGGT1;GLT8D1;4931440L10Rik;UGT2B3;GXYLT1 |
DPAGT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPAGT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPAGT1.
MFSD3
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