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DPM1

  • Official Full Name

    dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

  • Overview

    Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER).Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins.Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase.Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
  • Synonyms

    DPM1; dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit; dolichol-phosphate mannosyltransferase; CDGIE; MPDS; dolichol monophosphate mannose synthase; Dolichol phosphate mannose synthase; Dolichol-phosphate mannose synthase; Dolichyl phosphate beta D mannosyltransferase; dolichyl phosphate mannosyltransferase polypeptide 1; dolichyl phosphate mannosyltransferase polypeptide 1 catalytic subunit; Dolichyl-phosphate beta-D-mannosyltransferase; DPM synthase; DPM1_HUMAN; Mannose P dolichol synthase; Mannose-P-dolichol synthase; MPD synthase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • ABP
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DPM1-2836H Recombinant Human DPM1 Protein, GST-tagged Wheat Germ GST
Human DPM1-6835HCL Recombinant Human DPM1 293 Cell Lysate HEK293 N/A
Human DPM1-315H Recombinant Human DPM1 Protein, His/ABP-tagged E. coli His/ABP
Human DPM1-4079HF Recombinant Full Length Human DPM1 Protein, GST-tagged In Vitro Cell Free System GST 260 amino acids
Human DPM1-01H Recombinant Human DPM1 Protein, His-Tagged E.coli His
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RFL29232SF Recombinant Full Length Saccharomyces Cerevisiae Dolichol-Phosphate Mannosyltransferase(Dpm1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-267)
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) RFL7397UF Recombinant Full Length Ustilago Maydis Dolichol-Phosphate Mannosyltransferase(Dpm1) Protein, His-Tagged E.coli expression system His Full Length (1-294)
Zebrafish DPM1-1023Z Recombinant Zebrafish DPM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DPM1 involved in several pathways and played different roles in them. We selected most pathways DPM1 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
N-Glycan biosynthesisMGAT4B;B4GALT3;MGAT5;MGAT2;B4GALT2;MAN1A2;MAN1A1;MGAT3A;MOGS
Metabolic pathwaysPIP5K1BB;ATP6V0A4;ATP6V0D1;ALG11;ATP5B;ACOX1;GALNTL2;PGS1;GOT2A

DPM1 has several biochemical functions, for example, alcohol binding, dolichyl-phosphate beta-D-mannosyltransferase activity, dolichyl-phosphate-mannose-protein mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPM1 itself. We selected most functions DPM1 had, and list some proteins which have the same functions with DPM1. You can find most of the proteins on our site.

Function Related Protein
alcohol bindingCDIPT;DPM1
dolichyl-phosphate beta-D-mannosyltransferase activityDPM1;ALG5
dolichyl-phosphate-mannose-protein mannosyltransferase activityALG5;DPM1;SDF2
mannose bindingMANBA;CLEC4M;DPM1;LMAN2;BSG;MRC1;MBL2;CD209B;M6PR
protein bindingPNMA5;DDX47;FAM46D;ALKBH8;C1R;ADPRH;TRIM21;HBD;ATRIP

DPM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPM1.

ILK; DPM3; TDO2; MYC; PTP4A3; CIAO1; DPM2; TSC22D1; DPM3; TNFRSF14; BRF2

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