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DPM1
Official Full Name
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Background
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER).Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins.Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase.Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
Synonyms
AI118379; AI194292