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DPM3

  • Official Full Name

    dolichyl-phosphate mannosyltransferase polypeptide 3

  • Overview

    Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.
  • Synonyms

    DPM3; dolichyl-phosphate mannosyltransferase polypeptide 3; dolichol-phosphate mannosyltransferase subunit 3; MGC34275; MGC125904; MGC125905; prostin 1; prostin-1; MPD synthase subunit 3; DPM synthase complex subunit 3; mannose-P-dolichol synthase subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Dictyostelium discoideum (Slime mold)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DPM3-2838H Recombinant Human DPM3 Protein, GST-tagged Wheat Germ GST
Human DPM3-6833HCL Recombinant Human DPM3 293 Cell Lysate HEK293 N/A
Human DPM3-4080HF Recombinant Full Length Human DPM3 Protein, GST-tagged In Vitro Cell Free System GST 122 amino acids
Mouse DPM3-4791M Recombinant Mouse DPM3 Protein Mammalian Cell His
Mouse Dpm3-2639M Recombinant Mouse Dpm3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DPM3-2502M Recombinant Mouse DPM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DPM3-2502M-B Recombinant Mouse DPM3 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL12889BF Recombinant Full Length Bovine Dolichol-Phosphate Mannosyltransferase Subunit 3(Dpm3) Protein, His-Tagged E.coli expression system His Full Length (1-92)
Dictyostelium discoideum (Slime mold) RFL9061DF Recombinant Full Length Dictyostelium Discoideum Dolichol-Phosphate Mannosyltransferase Subunit 3(Dpm3) Protein, His-Tagged E.coli expression system His Full Length (1-92)
Homo sapiens (Human) RFL29735HF Recombinant Full Length Human Dolichol-Phosphate Mannosyltransferase Subunit 3(Dpm3) Protein, His-Tagged E.coli expression system His Full Length (1-92)
Mus musculus (Mouse) RFL6839MF Recombinant Full Length Mouse Dolichol-Phosphate Mannosyltransferase Subunit 3(Dpm3) Protein, His-Tagged E.coli expression system His Full Length (1-92)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL12832PF Recombinant Full Length Pongo Abelii Dolichol-Phosphate Mannosyltransferase Subunit 3(Dpm3) Protein, His-Tagged E.coli expression system His Full Length (1-92)
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) RFL28576SF Recombinant Full Length Schizosaccharomyces Pombe Dolichol-Phosphate Mannosyltransferase Subunit 3(Dpm3) Protein, His-Tagged E.coli expression system His Full Length (1-90)
Zebrafish DPM3-11065Z Recombinant Zebrafish DPM3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DPM3 Related Articles

DPM3 involved in several pathways and played different roles in them. We selected most pathways DPM3 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
N-Glycan biosynthesisALG14;FUT8A;DOLPP1;RPN1;DOLK;B4GALT2;ST6GAL1;B4GALT3;MGAT1A
Metabolic pathwaysPLA2G4F;FAH;DPM3;UCK1;PIP5K1AB;ALDOA;MINPP1A;HIBADHB;MGAT1

DPM3 has several biochemical functions, for example, contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPM3 itself. We selected most functions DPM3 had, and list some proteins which have the same functions with DPM3. You can find most of the proteins on our site.

Function Related Protein
contributes_to dolichyl-phosphate beta-D-mannosyltransferase activityDPM2;DPM3
protein bindingALG13;TMEM183A;AHSP;TMEM171;RPA2;C1D;DIRAS3;PLCE1;NOTCH2NL

DPM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPM3.

DPM1; Dpm2; DPM2; LRRK2

Yang, AC; Ng, BG; et al. Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy. MOLECULAR GENETICS AND METABOLISM 110:345-351(2013).
Barone, R; Aiello, C; et al. DPM2-CDG: A muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy. ANNALS OF NEUROLOGY 72:550-558(2012).
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