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DPP3

  • Official Full Name

    dipeptidyl-peptidase 3

  • Overview

    This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized.
  • Synonyms

    DPP3; dipeptidyl-peptidase 3; dipeptidylpeptidase 3 , dipeptidylpeptidase III; dipeptidyl peptidase 3; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; DPP III; DPP3_HUMAN; EC 3.4.14.4; dipeptidylpeptidase 3; dipeptidylpeptidase III; DPPIII;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DPP3-515H Recombinant Human Dipeptidyl-Peptidase 3, GST-tagged Sf9 Insect Cell GST
Human DPP3-28433TH Recombinant Human DPP3 N/A
Human DPP3-43H Recombinant Human DPP3 protein, His-tagged E.coli His 752aa(including fusion tag)
Human DPP3-2841H Recombinant Human DPP3 Protein, GST-tagged Wheat Germ GST
Human DPP3-6831HCL Recombinant Human DPP3 293 Cell Lysate HEK293 N/A
Human DPP3-6832HCL Recombinant Human DPP3 293 Cell Lysate HEK293 N/A
Human DPP3-1673H Recombinant Human DPP3 Protein (Met1-Ala737), N-His tagged E.coli N-His Met1-Ala737
Human DPP3-6457H Recombinant Human DPP3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DPP3-4116HF Recombinant Full Length Human DPP3 Protein, GST-tagged In Vitro Cell Free System GST 737 amino acids
Mouse Dpp3-1054M Recombinant Mouse Dpp3 protein, His & T7-tagged E.coli His/T7 Ala2~Glu263 (Accession # Q99KK7)
Mouse Dpp3-2640M Recombinant Mouse Dpp3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat DPP3-1942R Recombinant Rat DPP3 Protein Mammalian Cell His
Rat DPP3-1601R Recombinant Rat DPP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DPP3-1601R-B Recombinant Rat DPP3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DPP3-790Z Recombinant Zebrafish DPP3 Mammalian Cell His
Kit-1717 DPP3 Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DPP3 Related Research Area

DPP3 involved in several pathways and played different roles in them. We selected most pathways DPP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DPP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

DPP3 has several biochemical functions, for example, dipeptidyl-peptidase activity, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPP3 itself. We selected most functions DPP3 had, and list some proteins which have the same functions with DPP3. You can find most of the proteins on our site.

Function Related Protein
dipeptidyl-peptidase activityDPP4;DPEP3;DPP8;DPEP1;DPP7;DPEP2;PRCP;FAP;DPP3
metallopeptidase activityADAM21;CHMP1A;BRCC3;DPP3;MMP1A;TAF2;MMP25;ANPEPA;ERMP1
protein bindingNFYC;RRAD;NUP155;RAP1B;RASA1;ZNF423;LNX2B;BRIP1;STYX
zinc ion bindingLMO7;ADAMTS12;CA2;RNF34;MUL1;C11orf54;S100A3;KDM2BA;MT3

DPP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPP3.

KEAP1; OSBPL10; HSPA8; ATP5C1; TERF1; TINF2; POT1; TERF2IP

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does DPP3 play in metabolic processes? 11/09/2022

DPP3 is involved in the final stages of protein catabolism, breaking down small peptides into amino acids, which can then be reused in protein synthesis or participate in various metabolic pathways.

How is DPP3 expression regulated in various tissues? 10/14/2022

DPP3 expression varies among tissues, with higher levels in the heart, liver, and kidneys. Its expression is regulated by various factors, including hormonal and metabolic cues.

Are there any known inhibitors targeting DPP3, and what are their therapeutic implications? 06/01/2021

Some inhibitors targeting DPP3 have been identified, though their therapeutic implications are still under exploration. Inhibiting DPP3 might be beneficial in conditions where its overactivity contributes to disease pathology.

What is the significance of DPP3 in the context of drug metabolism? 01/02/2020

DPP3 is known to metabolize certain drugs, affecting their bioavailability and efficacy. Understanding DPP3's role in drug metabolism can help in drug design and dosage determination.

Are there any known diseases or conditions associated with mutations or dysregulation of DPP3? 06/02/2019

Dysregulation of DPP3 has been associated with certain cancers and inflammatory conditions. However, the exact pathological role of DPP3 in these conditions is still under investigation.

What is the primary function of the DPP3 gene and its encoded protein? 03/17/2019

The DPP3 gene encodes dipeptidyl peptidase III (DPP3), an intracellular zinc-dependent enzyme. Its primary function is to cleave dipeptides from the N-termini of polypeptides.

How does DPP3 differ from other dipeptidyl peptidases in terms of substrate specificity? 01/03/2019

Unlike other dipeptidyl peptidases, DPP3 has a broader substrate specificity, cleaving a variety of dipeptidyl-2-arylamide substrates and playing roles in multiple physiological processes.

Customer Reviews (3)

Write a review
Reviews
02/26/2021

    Fast delivery, great packaging.

    08/01/2020

      No issues, worked great.

      12/17/2018

        Quality better than expected.

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