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DPYD

  • Official Full Name

    dihydropyrimidine dehydrogenase

  • Overview

    The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
  • Synonyms

    DPYD; dihydropyrimidine dehydrogenase; DHP; DPD; DHPDHASE; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DPYD-2111H Recombinant Human DPYD protein, His & T7-tagged E.coli His/T7 Ile781~Cys1025 (Accession # Q12882)
Human DPYD-28437TH Recombinant Human DPYD Wheat Germ N/A 110 amino acids
Human DPYD-2860H Recombinant Human DPYD Protein, GST-tagged Wheat Germ GST
Human DPYD-28435TH Recombinant Human DPYD Wheat Germ N/A
Human DPYD-2533H Recombinant Human DPYD Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DPYD-1291H Recombinant Human DPYD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DPYD-2728H Recombinant Human DPYD protein, His-tagged E.coli His 4 - 99 aa
Human DPYD-1986H Recombinant Human DPYD Protein (Ile781-Cys1025), N-His tagged E.coli N-His Ile781-Cys1025
Human DPYD-786H Recombinant Human DPYD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DPYD-3724H Recombinant Human DPYD protein, GST-tagged E.coli GST 4-99 aa
Human DPYD-4165HF Recombinant Full Length Human DPYD Protein, GST-tagged In Vitro Cell Free System GST 173 amino acids
Human DPYD-503HFL Recombinant Full Length Human DPYD Protein, C-Flag-tagged Mammalian cells Flag
Human DPYD-786H-B Recombinant Human DPYD Protein Pre-coupled Magnetic Beads HEK293
Mouse Dpyd-2112M Recombinant Mouse Dpyd protein, His & T7-tagged E.coli His/T7 Pro169~Asp422 (Accession # Q8CHR6)
Mouse DPYD-4810M Recombinant Mouse DPYD Protein Mammalian Cell His
Mouse Dpyd-2649M Recombinant Mouse Dpyd Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DPYD-2518M-B Recombinant Mouse DPYD Protein Pre-coupled Magnetic Beads HEK293
Mouse DPYD-2518M Recombinant Mouse DPYD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DPYD-1947R Recombinant Rat DPYD Protein Mammalian Cell His
Rat DPYD-1606R Recombinant Rat DPYD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DPYD-1606R-B Recombinant Rat DPYD Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

DPYD involved in several pathways and played different roles in them. We selected most pathways DPYD participated on our site, such as Drug metabolism - other enzymes, Fluoropyrimidine Activity, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Drug metabolism - other enzymesCES1;UCKL1;IMPDH1B;UGT1A6B;IMPDH1;UGT1A3;XDH;TPMT;TK1
Fluoropyrimidine ActivityCES1;UPP2;DHFR;DPYD;TYMP;SLC22A7;DPYS
Metabolic pathwaysAmy1;CYP2J6;PPAP2B;PTGES3A;DHRS3;PAFAH2;ASMT;GOT2;PLA2G2F
MetabolismSLC26A1;CTRB1;MED25;CHP;ETFB;PDP1;CYGB1;ALOX5B.3;PAICS
Metabolism of nucleotidesTYMP;GLRX;ADSSL1;DUT;UPP2;DCK;AK7A;AK8;DPYS
Pantothenate and CoA biosynthesisPANK4;DPYDB;VNN2;BCAT1;PANK2;UPB1;PANK3;DPYD;COASY
Pyrimidine catabolismPROZA;DPYS;DPYD;UPP2;TYMP;DPYDA.1
Pyrimidine metabolismNME1-NME2;UCK2A;NME6;POLR3B;POLA2;NT5C3B;NT5C1B-RDH14;PNP5A;POLR1E

DPYD has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, NADP binding, dihydropyrimidine dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYD itself. We selected most functions DPYD had, and list some proteins which have the same functions with DPYD. You can find most of the proteins on our site.

Function Related Protein
4 iron, 4 sulfur cluster bindingNFU1;MUTYH;LIAS;POLE;ACO1;ACO2;IREB2;RSAD2;BRIP1
NADP bindingNDOR1;PGD;NOS1;GAPDHS;FMO3;NNT;GAPDH;POR;DPYD
dihydropyrimidine dehydrogenase (NADP+) activityDPYD;DPYDB
flavin adenine dinucleotide bindingCYBB;DLD;GCDHA;CRY-DASH;NOS2;ACOX2;KMO;DPYD;NOX4
metal ion bindingFTR54;PPARG;ZNF285A;FBXO5;SUZ12;HBB-Y;Car4;ZNF559-ZNF177;ZBTB7B
protein bindingIST1;IRF1;LCA5;KIR2DL4;MRPL10;SLC16A3;SYT16;STUB1;DPEP3
protein homodimerization activityAADAT;PDGFC;SDCBP2;USH1G;INHBB;PRMT8;CRYBA1;ACOT7;KIAA0947

DPYD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYD here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYD.

LXN; GOPC; fyuA; pelY; gyrA; q7cj40_yerpe; q7cjh7_yerpe; ebgC1; vacB; smc3; yapH; q8d0h5_yerpe; clpA3; phnK; xerC; tcaC1

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