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DRAP1

  • Official Full Name

    DR1-associated protein 1 (negative cofactor 2 alpha)

  • Overview

    Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans.Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
  • Synonyms

    DRAP1; DR1-associated protein 1 (negative cofactor 2 alpha); dr1-associated corepressor; DR1 associated corepressor; NC2 alpha; negative cofactor 2 alpha; DR1 associated protein 1 (negative cofactor 2 alpha); DR1 associated protein 1; DR1 associated protein1; DRAP 1; NC 2 alpha; NC 2alpha; Negative cofactor 2alpha; OTTHUMP00000234061; OTTHUMP00000234062; OTTHUMP00000234063; OTTHUMP00000234065; OTTHUMP00000234066; negative co-factor 2-alpha; NC2-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DRAP1-2670H Recombinant Human DRAP1, His-tagged E.coli His
Human DRAP1-2873H Recombinant Human DRAP1 Protein, GST-tagged Wheat Germ GST
Human DRAP1-6819HCL Recombinant Human DRAP1 293 Cell Lysate HEK293 N/A
Human DRAP1-4181HF Recombinant Full Length Human DRAP1 Protein, GST-tagged In Vitro Cell Free System GST 205 amino acids
Human DRAP1-1212H Recombinant Human DRAP1 Protein (4-198 aa), GST-tagged E.coli GST 4-198 aa
Human DRAP1-254H Recombinant Human DRAP1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse Drap1-2657M Recombinant Mouse Drap1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat DRAP1-1954R Recombinant Rat DRAP1 Protein Mammalian Cell His
Rat DRAP1-1613R Recombinant Rat DRAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DRAP1-1613R-B Recombinant Rat DRAP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DRAP1-1328R Recombinant Rhesus monkey DRAP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DRAP1-1153R Recombinant Rhesus Macaque DRAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DRAP1-1153R-B Recombinant Rhesus Macaque DRAP1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DRAP1-11589Z Recombinant Zebrafish DRAP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DRAP1 Related Articles

DRAP1 involved in several pathways and played different roles in them. We selected most pathways DRAP1 participated on our site, such as Developmental Biology, Signal Transduction, Signaling by Activin, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyMYL9;LEFTY1;TRPC3;FRS2A;COL9A1B;KCNQ3;ITSN1;CDON;AP2A1
Signal TransductionDEPDC1B;FAM13B1;CDC42EP3;SST;RGR;GPR37B;FGD4A;PDK4;PTPRK
Signaling by ActivinFOXH1;ACVR1C;FSTB;FST;DRAP1;FSTL3;INHBAA
Signaling by NODALFOXH1;ACVR1C;LEFTY1;CFC1;TDGF1;DRAP1;PCSK6;GDF1

DRAP1 has several biochemical functions, for example, DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DRAP1 itself. We selected most functions DRAP1 had, and list some proteins which have the same functions with DRAP1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingDMRT3;INSM1A;NR5A2;POLDIP2;CCNT1;ZBTB3;RORCB;DEDD2;Rhox5
protein bindingPOLR2J;CHUK;CPNE1;SOX4;TXN2;TFDP2;VEGFC;CNOT3;EIF2A
protein heterodimerization activityAGTR1A;TGFB3;BAD;HIST4H4;IKBKG;HSPD1;KCNA3;CENPW;MYH7
transcription corepressor activityRYBP;TFCP2L1;PSMC3;E2F7;SAP18;HOMEZ;CBX4;APEX1;HDAC7A
transcription factor activity, sequence-specific DNA bindingFOXO3;ZFP629;DMRT3;FOXG1A;ZFP30;SOX5;PLAG1;TA;ZNF583
transcription factor bindingMED25;REST;CHCHD2;PAX2;HMGB1;HMGA2;HEY1;RORA;PBX2

DRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRAP1.

TAF9; NFYB; TAF9B; POLE3; LMO2

Kantidakis, T; White, RJ; et al. Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells. NUCLEIC ACIDS RESEARCH 38:1228-1239(2010).
Valdagni, R; Rancati, T; et al. TO BLEED OR NOT TO BLEED. A PREDICTION BASED ON INDIVIDUAL GENE PROFILING COMBINED WITH DOSE-VOLUME HISTOGRAM SHAPES IN PROSTATE CANCER PATIENTS UNDERGOING THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 74:1431-1440(2009).
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