DRD1
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Official Full Name
dopamine receptor D1
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Overview
The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2 mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. Dopamine receptor D1 has been reported mostly in various regions of the brain. ESTs have been isolated from normal olfactory epithelium and cancerous genitourinary tract libraries. -
Synonyms
DRD1; dopamine receptor D1; DADR; DRD1A; D(1A) dopamine receptor; Dopamine D1 receptor; OTTHUMP00000161116;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Oryctolagus cuniculus (Rabbit)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Xenopus laevis (African clawed frog)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Flag
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DRD1 Related Gene Family
- DRD1 Related Research Area
DRD1 involved in several pathways and played different roles in them. We selected most pathways DRD1 participated on our site, such as Alcoholism, Amine ligand-binding receptors, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alcoholism | HDAC10;MAOA;GRIN3B;HIST2H3C;HIST1H3G;GNG3;HIST1H3F;CREB3L1;NPY |
Amine ligand-binding receptors | CHRM5;TAAR1;ADRA2A;CHRM2;DRD1;CHRM4;HRH3;ADRB1;ADRA1D |
Calcium signaling pathway | EGFRA;AGTR1A;CACNA1D;PTAFR;AKR1C1;PRKCBA;HTR4;EDNRBA;EDNRA |
Class A/1 (Rhodopsin-like receptors) | OPN5;KEL;ADRA1B;ZFPM2B;RLN3A;RHOL;ADRA2A;GPR31;GPR37L1 |
Cocaine addiction | GPSM1;DDC;GRIA2;CREB3L3;CREB5;RELA;GRIN2C;PRKACB;DLG4 |
Dopamine receptors | DRD3;DRD2;DRD1;DRD4;DRD5 |
Dopaminergic synapse | PRKACB;CREB5;TH;SLC6A3;GRIA2;GNGT2;SLC18A1;GNB3;DRD5 |
DRD1 has several biochemical functions, for example, ATPase binding, D3 dopamine receptor binding, G-protein alpha-subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD1 itself. We selected most functions DRD1 had, and list some proteins which have the same functions with DRD1. You can find most of the proteins on our site.
Function | Related Protein |
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ATPase binding | PKD2;ATP1B1;PEX26;USP25;FBL;ANK1;METTL21A;ATP6V1G1;Ar |
D3 dopamine receptor binding | CLIC6;DRD1A;DRD1;PALM |
G-protein alpha-subunit binding | CRHR1;RGS19;RIC8A;RGS14;F2R;RIC8;PPP5C;HTR2A;DRD1A |
G-protein coupled amine receptor activity | DRD1A;TAAR7F;DRD1;TAAR8B;TAAR13C;TAAR8A;DRD5;GPR21;DRD4-RS |
angiotensin receptor binding | DRD1A;ARRB1;ARRB2;DRD1 |
dopamine binding | DRD2L;GPR143;DRD1;TH;SLC6A3;DRD2;DRD5;DRD1B;DRD3 |
dopamine neurotransmitter receptor activity | DRD2A;DRD1;DRD5;DRD4B;DRD4;DRD4A;DRD1A;DRD4-RS;DRD2L |
dopamine neurotransmitter receptor activity, coupled via Gs | DRD5;DRD1;DRD1A;DRD1B |
drug binding | FSCN1;CHRNA3;GRIK1;HTR2B;PDE4D;CHRM1;P2RX4;P2RX1;GABRA1 |
protein binding | POLDIP2;SOST;NQO2;TTC39B;MTMR2;PCGF6;E2F1;TACC1;DDX20 |
protein complex binding | LZTFL1;ATP6V1B1;C8A;CRIPT;CDK5RAP2;SHANK1;ATM;ANKRD54;NASP |
protein heterodimerization activity | NR4A2;EXT2;MYOG;H2AFVA;HIST1H2BE;CHRNB4;AGTR1;DMRT3;CXorf15 |
protein phosphatase binding | MET;ROS1;ANAPC5;MAPK14;TRP53;MAP2K7;VCP;FLT4;JUPA |
DRD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD1.
sch_23390
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- Reviews
Q&As (7)
Ask a questionGenetic mutations in DRD1 can alter dopamine signaling and brain function.
DRD1 is involved in various psychiatric and neurological disorders.
It significantly modulates cognitive abilities and behavior.
DRD1 is crucial for dopamine-mediated neurotransmission, influencing brain function.
Targeting DRD1 offers therapeutic potential for neurological and psychiatric conditions.
DRD1 works with other dopamine receptors, contributing to neural networks.
Changes in DRD1 activity disrupt normal dopamine signaling, affecting mental health.
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