DRD2
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Official Full Name
dopamine receptor D2
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Overview
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008] -
Synonyms
DRD2; dopamine receptor D2; D2R; D2DR; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Chicken
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Homo sapiens (Human)
- Human
- Meleagris gallopavo (Wild turkey)
- Mouse
- Mus musculus (Mouse)
- Mustela putorius furo (European domestic ferret) (Mustela furo)
- Pan troglodytes (Chimpanzee)
- Rat
- Rattus norvegicus (Rat)
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- Flag
- Myc
- His|GST
- His|T7
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | DRD2-16H | Recombinant Human DRD2 Protein, His-tagged | E.coli | His | ||
Human | DRD2-11H | Recombinant Human DRD2 | Wheat Germ | N/A | ||
Human | DRD2-21HL | Recombinant Human DRD2 HEK293T cell lysate | HEK293T | Myc/DDK | ||
Human | DRD2-6817HCL | Recombinant Human DRD2 293 Cell Lysate | HEK293 | N/A | ||
Human | DRD2-1785H | Recombinant Human DRD2 protein, His & GST-tagged | E.coli | His/GST | Val200~Ile384 | |
Human | DRD2-1099HFL | Recombinant Human DRD2 protein, His&Flag-tagged | HEK293 | His&Flag | 1-443 aa | |
Human | DRD2-17H | Recombinant Human DRD2 Protein, His-tagged | E. coli | His | ||
Human | DRD2-4221H | Recombinant Human DRD2 protein, His&Myc-tagged | E.coli | His&Myc | 214-373aa | |
Human | DRD2-1381H | Recombinant Human DRD2 Protein, His-tagged | E.coli | N-His | Ser194-Ala420 | |
Human | DRD2-6910HF | Recombinant Full Length Human DRD2 Protein | In Vitro Cell Free System | 443 amino acids | ||
Human | DRD2-1991H | Recombinant Human DRD2 Protein (Lys221-Gln373), N-His tagged | E.coli | N-His | Lys221-Gln373 | |
Mouse | DRD2-4823M | Recombinant Mouse DRD2 Protein | Mammalian Cell | His | ||
Mouse | DRD2-2527M | Recombinant Mouse DRD2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | DRD2-1235M | Recombinant Mouse DRD2 protein, His-tagged | E.coli | His | Ser194~Ala421 | |
Mouse | DRD2-2527M-B | Recombinant Mouse DRD2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Drd2-762R | Recombinant Rat Drd2 protein, His & T7-tagged | E.coli | His/T7 | Ser194~Ala421 (Accession # P61169) | |
Rat | DRD2-1956R | Recombinant Rat DRD2 Protein | Mammalian Cell | His | ||
Rat | DRD2-1615R | Recombinant Rat DRD2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | DRD2-1615R-B | Recombinant Rat DRD2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Bos taurus (Bovine) | RFL25541BF | Recombinant Full Length Bovine D(2) Dopamine Receptor(Drd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-444) | |
Canis lupus familiaris (Dog) (Canis familiaris) | RFL3849CF | Recombinant Full Length Dog D(2) Dopamine Receptor(Drd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-443) | |
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) | RFL30264CF | Recombinant Full Length Chlorocebus Aethiops D(2) Dopamine Receptor Protein, His-Tagged | E.coli expression system | His | Full Length (1-443) | |
Homo sapiens (Human) | RFL26636HF | Recombinant Full Length Human D(2) Dopamine Receptor(Drd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-443) | |
Meleagris gallopavo (Wild turkey) | RFL16261MF | Recombinant Full Length Meleagris Gallopavo D(2) Dopamine Receptor Protein, His-Tagged | E.coli expression system | His | Full Length (1-436) | |
Mus musculus (Mouse) | RFL18269MF | Recombinant Full Length Mouse D(2) Dopamine Receptor(Drd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-444) | |
Mustela putorius furo (European domestic ferret) (Mustela furo) | RFL5456MF | Recombinant Full Length Mustela Putorius Furo D(2) Dopamine Receptor(Drd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-443) | |
Pan troglodytes (Chimpanzee) | RFL14492PF | Recombinant Full Length Pan Troglodytes D(2) Dopamine Receptor Protein, His-Tagged | E.coli expression system | His | Full Length (1-443) | |
Rattus norvegicus (Rat) | RFL29848RF | Recombinant Full Length Rat D(2) Dopamine Receptor(Drd2) Protein, His-Tagged | E.coli expression system | His | Full Length (1-444) | |
Chicken | DRD2-3800C | Recombinant Chicken DRD2 | Mammalian Cell | His | ||
Kit-1215 | cAMP DRD2 (Short Isoform) CHO-K1 GPCR Assay Kit | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- DRD2 Related Articles
- DRD2 Related Gene Family
- DRD2 Related Research Area
DRD2 involved in several pathways and played different roles in them. We selected most pathways DRD2 participated on our site, such as Alcoholism, Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alcoholism | GNG8;HIST4H4;GNB4;SLC18A1;HIST1H2BD;GNG2;HIST3H2A;HIST1H3D;GNAI2 |
Amine ligand-binding receptors | ADRB3;ADRA2C;DRD4;DRD3;DRD2;ADRA2A;TAAR1;CHRM5;ADRA1D |
Class A/1 (Rhodopsin-like receptors) | GPR37L1;CCR7;GPR18;CCR1;NMBB;PRLH;ZFPM2B;AMCF-II;INSL5 |
Cocaine addiction | NFKB1;RGS9;CREB3L2;SLC18A2;SLC6A3;CREB5;CREB3L3;PDYN;GRIN3A |
Dopamine receptors | DRD4;DRD5;DRD2;DRD3;DRD1 |
Dopaminergic synapse | GRIN2B;GNG2;GRIA3;DDC;FOS;GNG11;PPP2R5D;PLCB3;ATF4 |
G alpha (i) signalling events | RGS10;INSL5;FPR-RS6;RGS20;GPR17;GPR55A;DRD4;CCR7;GPR18 |
GPCR downstream signaling | FGD4A;NPB;TRPC6A;CCL27;ANXA1C;OR10A5;RAMP1;GRP;SSTR1 |
DRD2 has several biochemical functions, for example, NOT adrenergic receptor activity, dopamine binding, dopamine neurotransmitter receptor activity, coupled via Gi/Go. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD2 itself. We selected most functions DRD2 had, and list some proteins which have the same functions with DRD2. You can find most of the proteins on our site.
Function | Related Protein |
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NOT adrenergic receptor activity | DRD2;DRD2L;DRD2A;DRD2B |
dopamine binding | DRD2B;DRD5;TH;ADRB2;DRD3;DRD2A;DRD1A;DRD4;DRD2 |
dopamine neurotransmitter receptor activity, coupled via Gi/Go | DRD2L;DRD4B;DRD2B;DRD4;DRD2A;DRD2;DRD3;DRD4A;DRD4-RS |
drug binding | TLR8;SRP54B;ABP1;DCK;FASN;DRD4;PYGL;PDE4C;GLRB |
identical protein binding | PRC1;STXBP1;APOH;LYZ2;PFKFB1;L3MBTL1;KLHL7;NDC80;CRYAA |
ionotropic glutamate receptor binding | GNAS;ADRB2;DRD2;DLG4B;DLG4;SHANK2;CACNG2;SHANK3;CANX |
potassium channel regulator activity | DPP10;CHP;SGK1;LRRC26;KCNE3;AMIGO1;SGK2;KCNIP3;ARPP19A |
protein binding | METTL17;SKP1;USP42;PARD6A;C16orf48;CD164;MFN2;PSMB4;PAEP |
protein heterodimerization activity | HIST1H3H;TLR2;ABTB2;IKZF4;TAF11;BOKB;TAF12;HIST1H4I;TGFB3 |
protein homodimerization activity | QDPR;TERT;IKBKG;NBL1;HPGD;BCL2A1A;SMAD1;ERP29;IZUMO3 |
DRD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD2.
SLC6A3; ADORA2A; CALM1; butaclamol; spiperone; PPP1R9B
- Q&As
- Reviews
Q&As (7)
Ask a questionTargeting DRD2 could treat disorders like Parkinson's and schizophrenia.
Genetic variations in DRD2 influence behavioral and mental health responses.
It regulates motor control via dopamine pathways.
DRD2 collaborates with other dopamine receptors in brain functions.
DRD2 modulates neurotransmitter signaling in the brain.
DRD2 is key in psychiatric conditions, affecting mood and cognition.
Altered DRD2 activity is linked to addiction, affecting reward mechanisms.
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