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DRD2

  • Official Full Name

    dopamine receptor D2

  • Overview

    This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
  • Synonyms

    DRD2; dopamine receptor D2; D2R; D2DR; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Homo sapiens (Human)
  • Human
  • Meleagris gallopavo (Wild turkey)
  • Mouse
  • Mus musculus (Mouse)
  • Mustela putorius furo (European domestic ferret) (Mustela furo)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Flag
  • Myc
  • His|GST
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DRD2-16H Recombinant Human DRD2 Protein, His-tagged E.coli His
Human DRD2-11H Recombinant Human DRD2 Wheat Germ N/A
Human DRD2-21HL Recombinant Human DRD2 HEK293T cell lysate HEK293T Myc/DDK
Human DRD2-6817HCL Recombinant Human DRD2 293 Cell Lysate HEK293 N/A
Human DRD2-1785H Recombinant Human DRD2 protein, His & GST-tagged E.coli His/GST Val200~Ile384
Human DRD2-1099HFL Recombinant Human DRD2 protein, His&Flag-tagged HEK293 His&Flag 1-443 aa
Human DRD2-17H Recombinant Human DRD2 Protein, His-tagged E. coli His
Human DRD2-4221H Recombinant Human DRD2 protein, His&Myc-tagged E.coli His&Myc 214-373aa
Human DRD2-1381H Recombinant Human DRD2 Protein, His-tagged E.coli N-His Ser194-Ala420
Human DRD2-6910HF Recombinant Full Length Human DRD2 Protein In Vitro Cell Free System 443 amino acids
Human DRD2-1991H Recombinant Human DRD2 Protein (Lys221-Gln373), N-His tagged E.coli N-His Lys221-Gln373
Mouse DRD2-4823M Recombinant Mouse DRD2 Protein Mammalian Cell His
Mouse DRD2-2527M Recombinant Mouse DRD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DRD2-1235M Recombinant Mouse DRD2 protein, His-tagged E.coli His Ser194~Ala421
Mouse DRD2-2527M-B Recombinant Mouse DRD2 Protein Pre-coupled Magnetic Beads HEK293
Rat Drd2-762R Recombinant Rat Drd2 protein, His & T7-tagged E.coli His/T7 Ser194~Ala421 (Accession # P61169)
Rat DRD2-1956R Recombinant Rat DRD2 Protein Mammalian Cell His
Rat DRD2-1615R Recombinant Rat DRD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DRD2-1615R-B Recombinant Rat DRD2 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL25541BF Recombinant Full Length Bovine D(2) Dopamine Receptor(Drd2) Protein, His-Tagged E.coli expression system His Full Length (1-444)
Canis lupus familiaris (Dog) (Canis familiaris) RFL3849CF Recombinant Full Length Dog D(2) Dopamine Receptor(Drd2) Protein, His-Tagged E.coli expression system His Full Length (1-443)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL30264CF Recombinant Full Length Chlorocebus Aethiops D(2) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-443)
Homo sapiens (Human) RFL26636HF Recombinant Full Length Human D(2) Dopamine Receptor(Drd2) Protein, His-Tagged E.coli expression system His Full Length (1-443)
Meleagris gallopavo (Wild turkey) RFL16261MF Recombinant Full Length Meleagris Gallopavo D(2) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-436)
Mus musculus (Mouse) RFL18269MF Recombinant Full Length Mouse D(2) Dopamine Receptor(Drd2) Protein, His-Tagged E.coli expression system His Full Length (1-444)
Mustela putorius furo (European domestic ferret) (Mustela furo) RFL5456MF Recombinant Full Length Mustela Putorius Furo D(2) Dopamine Receptor(Drd2) Protein, His-Tagged E.coli expression system His Full Length (1-443)
Pan troglodytes (Chimpanzee) RFL14492PF Recombinant Full Length Pan Troglodytes D(2) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-443)
Rattus norvegicus (Rat) RFL29848RF Recombinant Full Length Rat D(2) Dopamine Receptor(Drd2) Protein, His-Tagged E.coli expression system His Full Length (1-444)
Chicken DRD2-3800C Recombinant Chicken DRD2 Mammalian Cell His
Kit-1215 cAMP DRD2 (Short Isoform) CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DRD2 Related Articles
  • DRD2 Related Gene Family
  • DRD2 Related Research Area

DRD2 involved in several pathways and played different roles in them. We selected most pathways DRD2 participated on our site, such as Alcoholism, Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismGNG8;HIST4H4;GNB4;SLC18A1;HIST1H2BD;GNG2;HIST3H2A;HIST1H3D;GNAI2
Amine ligand-binding receptorsADRB3;ADRA2C;DRD4;DRD3;DRD2;ADRA2A;TAAR1;CHRM5;ADRA1D
Class A/1 (Rhodopsin-like receptors)GPR37L1;CCR7;GPR18;CCR1;NMBB;PRLH;ZFPM2B;AMCF-II;INSL5
Cocaine addictionNFKB1;RGS9;CREB3L2;SLC18A2;SLC6A3;CREB5;CREB3L3;PDYN;GRIN3A
Dopamine receptorsDRD4;DRD5;DRD2;DRD3;DRD1
Dopaminergic synapseGRIN2B;GNG2;GRIA3;DDC;FOS;GNG11;PPP2R5D;PLCB3;ATF4
G alpha (i) signalling eventsRGS10;INSL5;FPR-RS6;RGS20;GPR17;GPR55A;DRD4;CCR7;GPR18
GPCR downstream signalingFGD4A;NPB;TRPC6A;CCL27;ANXA1C;OR10A5;RAMP1;GRP;SSTR1

DRD2 has several biochemical functions, for example, NOT adrenergic receptor activity, dopamine binding, dopamine neurotransmitter receptor activity, coupled via Gi/Go. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD2 itself. We selected most functions DRD2 had, and list some proteins which have the same functions with DRD2. You can find most of the proteins on our site.

Function Related Protein
NOT adrenergic receptor activityDRD2;DRD2L;DRD2A;DRD2B
dopamine bindingDRD2B;DRD5;TH;ADRB2;DRD3;DRD2A;DRD1A;DRD4;DRD2
dopamine neurotransmitter receptor activity, coupled via Gi/GoDRD2L;DRD4B;DRD2B;DRD4;DRD2A;DRD2;DRD3;DRD4A;DRD4-RS
drug bindingTLR8;SRP54B;ABP1;DCK;FASN;DRD4;PYGL;PDE4C;GLRB
identical protein bindingPRC1;STXBP1;APOH;LYZ2;PFKFB1;L3MBTL1;KLHL7;NDC80;CRYAA
ionotropic glutamate receptor bindingGNAS;ADRB2;DRD2;DLG4B;DLG4;SHANK2;CACNG2;SHANK3;CANX
potassium channel regulator activityDPP10;CHP;SGK1;LRRC26;KCNE3;AMIGO1;SGK2;KCNIP3;ARPP19A
protein bindingMETTL17;SKP1;USP42;PARD6A;C16orf48;CD164;MFN2;PSMB4;PAEP
protein heterodimerization activityHIST1H3H;TLR2;ABTB2;IKZF4;TAF11;BOKB;TAF12;HIST1H4I;TGFB3
protein homodimerization activityQDPR;TERT;IKBKG;NBL1;HPGD;BCL2A1A;SMAD1;ERP29;IZUMO3

DRD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD2.

SLC6A3; ADORA2A; CALM1; butaclamol; spiperone; PPP1R9B

Prast, JM; Schardl, A; et al. Reacquisition of cocaine conditioned place preference and its inhibition by previous social interaction preferentially affect D1-medium spiny neurons in the accumbens corridor. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).
Qu, BX; Gong, YH; et al. Beta-amyloid auto-antibodies are reduced in Alzheimer's disease. JOURNAL OF NEUROIMMUNOLOGY 274:168-173(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What potential therapeutic applications arise from targeting DRD2 in neurological disorders? 05/30/2023

Targeting DRD2 could treat disorders like Parkinson's and schizophrenia.

How do genetic variations in DRD2 affect behavior? 03/20/2019

Genetic variations in DRD2 influence behavioral and mental health responses.

How does DRD2 contribute to motor control? 01/10/2019

It regulates motor control via dopamine pathways.

How does DRD2 interact with other dopamine receptors? 10/05/2018

DRD2 collaborates with other dopamine receptors in brain functions.

What is the primary role of DRD2 in neurotransmission? 03/26/2018

DRD2 modulates neurotransmitter signaling in the brain.

What role does DRD2 play in psychiatric disorders? 03/26/2018

DRD2 is key in psychiatric conditions, affecting mood and cognition.

What is the impact of altered DRD2 activity on addiction? 03/23/2017

Altered DRD2 activity is linked to addiction, affecting reward mechanisms.

Customer Reviews (3)

Write a review
Reviews
01/10/2019

    Integral to our research success, highly recommended.

    03/26/2018

      Efficiency at its best, a research cornerstone.

      03/26/2018

        Swift and accurate service, accelerates research timelines.

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