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DRD5

  • Official Full Name

    dopamine receptor D5

  • Overview

    This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This receptor is neuron specific, localized primarily within limbic regions of the brain. Defects in DRD5 are a cause of blepharospasm and may be a cause of schizophrenia.
  • Synonyms

    DRD5; dopamine receptor D5; DBDR; DRD1B; DRD1L2; MGC10601; D(1B) dopamine receptor; OTTHUMP00000158603; dopamine D5 receptor; dopamine receptor D1B; d(5) dopamine receptor; D1beta dopamine receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus laevis (African clawed frog)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DRD5-12165H Recombinant Human DRD5, His-tagged E.coli His C-term-127a.a.
Human DRD5-12H Recombinant Human DRD5 Wheat Germ N/A
Human DRD5-13H Active Recombinant Human DRD5, GST-tagged E.coli GST
Human DRD5-6816HCL Recombinant Human DRD5 293 Cell Lysate HEK293 N/A
Human DRD5-1383H Recombinant Human DRD5 Protein, His-tagged E.coli N-His Ala360-His477
Human DRD5-6912HF Recombinant Full Length Human DRD5 Protein In Vitro Cell Free System 477 amino acids
Human DRD5-1992H Recombinant Human DRD5 Protein (Asn351-His477), His tagged E.coli His Asn351-His477
Human DRD5-1993H Recombinant Human DRD5 Protein (Phe361-His477), N-His tagged E.coli N-His Phe361-His477
Rat DRD5-1959R Recombinant Rat DRD5 Protein Mammalian Cell His
Rat DRD5-1618R Recombinant Rat DRD5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat DRD5-1618R-B Recombinant Rat DRD5 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL20175HF Recombinant Full Length Human D(1B) Dopamine Receptor(Drd5) Protein, His-Tagged E.coli expression system His Full Length (1-477)
Mus musculus (Mouse) RFL16471MF Recombinant Full Length Mouse D(1B) Dopamine Receptor(Drd5) Protein, His-Tagged E.coli expression system His Full Length (1-478)
Rattus norvegicus (Rat) RFL20193RF Recombinant Full Length Rat D(1B) Dopamine Receptor(Drd5) Protein, His-Tagged E.coli expression system His Full Length (1-475)
Xenopus laevis (African clawed frog) RFL5863XF Recombinant Full Length Xenopus Laevis D(1B) Dopamine Receptor Protein, His-Tagged E.coli expression system His Full Length (1-457)
Kit-1218 DRD5 CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-0962 TR-FRET LXR alpha Coactivator Assay Kit, rabbit N/A
Kit-1071 Deubiquitinase Activity Assay Kit (Fluorometric) N/A
Kit-1219 cAMP DRD5 CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DRD5 Related Articles
  • DRD5 Related Research Area

DRD5 involved in several pathways and played different roles in them. We selected most pathways DRD5 participated on our site, such as Amine ligand-binding receptors, Calcium signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with DRD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine ligand-binding receptorsHRH3;DRD4;ADRA2B;CHRM5;DRD1;ADRA1D;DRD3;ADRA2A;ADRB3
Calcium signaling pathwayADORA2AB;ADRa1A;ITPKB;P2RX8;GRPR;ORAI1;TRHR2;TNNC1B;MYLK2
Class A/1 (Rhodopsin-like receptors)FPR-RS6;OXGR1A.2;CHRM1;GPR37B;DRD2;CCK;APLNR;NMU;CCL35.2
Dopamine receptorsDRD3;DRD2;DRD1;DRD5;DRD4
Dopaminergic synapseSLC18A1;KCNJ5;PPP2R1B;PPP2R5A;ARNTL;KCNJ3;ATF4;CREB3;PRKCG
G alpha (s) signalling eventsNPS;ADRB3;ADORA2B;PTHRP2;CALCB;RLN3;PTH2;ADM2A;RAMP3
GPCR downstream signalingSSTR2;GPR55;OR10A5;SCT;FPR-RS3;CCL19A.2;TIAM2;FPR-RS4;TRPC7
GPCR ligand bindingAPLNR;CHRM1;LPAR2A;CRHR2;GPBAR1;OXGR1A.2;ADCYAP1B;RCA2.1;OPN4

DRD5 has several biochemical functions, for example, G-protein coupled amine receptor activity, dopamine binding, dopamine neurotransmitter receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DRD5 itself. We selected most functions DRD5 had, and list some proteins which have the same functions with DRD5. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled amine receptor activityTAAR7B;TAAR6;DRD1A;GPR161;TAAR8C;DRD4B;DRD1;TAAR8B;TAAR7F
dopamine bindingDRD1;SLC6A3;TH;DRD2B;DRD3;DRD2;DRD2L;DRD4;DRD1A
dopamine neurotransmitter receptor activityDRD1B;DRD2A;DRD5;DRD4-RS;DRD4B;DRD2B;DRD1;DRD7;DRD4
dopamine neurotransmitter receptor activity, coupled via GsDRD5;DRD1B;DRD1;DRD1A

DRD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRD5.

Hawi, Z; RCummins, TD; et al. The molecular genetic architecture of attention deficit hyperactivity disorder. MOLECULAR PSYCHIATRY 20:289-297(2015).
Sriram, K; Jefferson, AM; et al. Neurotoxicity following acute inhalation of aerosols generated during resistance spot weld-bonding of carbon steel. INHALATION TOXICOLOGY 26:720-732(2014).
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