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DROSHA

  • Official Full Name

    drosha, ribonuclease type III

  • Overview

    Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]
  • Synonyms

    DROSHA; drosha, ribonuclease type III; RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976; ribonuclease 3; p241; RNase III; protein Drosha; nuclear RNase III Drosha; putative ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; drosha, double-stranded RNA-specific endoribonuclease; putative protein p241 which interacts with transcription factor Sp1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DROSHA-7909H Recombinant Human DROSHA protein, His-tagged E.coli His Ile1114~Glu1235
Human DROSHA-423HCL Recombinant Human DROSHA Lysate HEK293 Myc/DDK
Human DROSHA-424HCL Recombinant Human DROSHA Lysate HEK293 Myc/DDK
Human DROSHA-3741H Recombinant Human DROSHA protein, GST-tagged E.coli GST 353-550 aa
Human DROSHA-5830H Recombinant Human DROSHA Protein (Arg28-Met160), C-His tagged Mammalian cells C-His Arg28-Met160
Mouse DROSHA-4829M Recombinant Mouse DROSHA Protein Mammalian Cell His
Mouse DROSHA-2532M Recombinant Mouse DROSHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DROSHA-2532M-B Recombinant Mouse DROSHA Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DROSHA-1333R Recombinant Rhesus monkey DROSHA Protein, His-tagged Mammalian Cell His
Rhesus Macaque DROSHA-1158R Recombinant Rhesus Macaque DROSHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DROSHA-1158R-B Recombinant Rhesus Macaque DROSHA Protein Pre-coupled Magnetic Beads HEK293
Chicken DROSHA-1522C Recombinant Chicken DROSHA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DROSHA Related Articles

DROSHA involved in several pathways and played different roles in them. We selected most pathways DROSHA participated on our site, such as Ribosome biogenesis in eukaryotes, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DROSHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ribosome biogenesis in eukaryotesNXT1;NOP10;BARHL1;NHP2L1A;XRN2;WDR43;UTP14C;PWP2;MPHOSPH10
Proteoglycans in cancerEZR;STAT3;HPSE2;PDPK1;IGF1;MTOR;MAPK12;SOS1;PLCE1

DROSHA has several biochemical functions, for example, RNA binding, double-stranded RNA binding, endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DROSHA itself. We selected most functions DROSHA had, and list some proteins which have the same functions with DROSHA. You can find most of the proteins on our site.

Function Related Protein
RNA bindingUPF3A;RBM39A;OASL1;HNRNPUL1;RNASEL;BARHL1;SYNCRIP;PUSL1;NHP2L1B
double-stranded RNA bindingOAS1;RNASEN;TFRC;MBNL1;MYH4;LSM14A;ACTN1;TLR8;TARBP2
endonuclease activityRNASE4;DIS3;DCLRE1C;ENDOG;FEN1;ENDOU2;RSFR;CENPT;RNASE3
endoribonuclease activityRNASEL;RNASEKB;ENDOU2;ERN1;CPSF3;DROSHA;TSN;AGO2;RNASEK
hydrolase activityLIPM;CTSM;EAR2;MMAA;USP43;REXO4;MMP23BB;ABHD14B;MOV10B.1
lipopolysaccharide bindingBPI;TRIL;LBP;SELP;TLR4;CD6;KIAA0644;TREM2;CD14
metal ion bindingZNF75A;MOB4;FBXL19;ZNF263;SPNA1;MTMR4;MOBKL1A;SPRTN;SMPD3
nuclease activityDROSHA;RNASEL3;TDP2;TMPPE;EXO5;PARN;RNASEL2;ZRANB3;RNASEKA
poly(A) RNA bindingSUPV3L1;RBPMS;CAST;MEX3C;RTCA;PRPF38B;LARP4B;RPS15A;CD3EAP
protein bindingPOLR2A;PA2G4;SETD6;HSP90AA1.2;NFKB1;SMAD1;BRSK1;FAIM;TIE1
protein homodimerization activityCRTAM;PLEK;GCA;TNNC1;SLC22A1;CD8A;GRIK2;BCL2A;GOT2
ribonuclease III activityRNASEN;BARHL1;AGFG1A;DICER1;DROSHA;MRPL44

DROSHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DROSHA here. Most of them are supplied by our site. Hope this information will be useful for your research of DROSHA.

Ddx17

Alarcon, CR; Lee, H; et al. N-6-methyladenosine marks primary microRNAs for processing. NATURE 519:482-+(2015).
Walz, AL; Ooms, A; et al. Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors (vol 27, pg 286, 2015). CANCER CELL 27:426-426(2015).
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