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DSC2

  • Official Full Name

    desmocollin 2

  • Overview

    The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.
  • Synonyms

    DSC2; desmocollin 2; DSC3; desmocollin-2; CDHF2; cadherin family member 2; desmosomal glycoprotein II; desmosomal glycoprotein III; desmosomal glycoprotein II/III; DG2; ARVD11; DGII/III; DKFZp686I11137;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DSC2-3856H Recombinant Human DSC2 protein, His-tagged HEK293 His Met1-Arg684
Human DSC2-2878H Recombinant Human DSC2 Protein, GST-tagged Wheat Germ GST
Human DSC2-2051HCL Recombinant Human DSC2 cell lysate Human Cell N/A
Human DSC2-4443H Recombinant Human DSC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DSC2-2527H Recombinant Human DSC2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DSC2-478H Recombinant Human DSC2 Protein, His-tagged E.coli His Arg136~Cys471
Human DSC2-4195HF Recombinant Full Length Human DSC2 Protein, GST-tagged In Vitro Cell Free System GST 847 amino acids
Mouse DSC2-4832M Recombinant Mouse DSC2 Protein Mammalian Cell His
Mouse Dsc2-2662M Recombinant Mouse Dsc2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DSC2-2534M-B Recombinant Mouse DSC2 Protein Pre-coupled Magnetic Beads HEK293
Mouse DSC2-2534M Recombinant Mouse DSC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Dsc2-8753R Recombinant Rat Dsc2, His tagged Human Cell His
Rat DSC2-1159RCL Recombinant Rat DSC2 cell lysate Human Cell N/A
Bos taurus (Bovine) RFL36737BF Recombinant Full Length Bovine Desmocollin-2(Dsc2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (90-863)
Mus musculus (Mouse) RFL5362MF Recombinant Full Length Mouse Desmocollin-2(Dsc2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (136-902)
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) RFL5242SF Recombinant Full Length Schizosaccharomyces Pombe Uba Domain-Containing Protein 14(Ucp14) Protein, His-Tagged E.coli expression system His Full Length (1-372)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DSC2 Related Articles
  • DSC2 Related Research Area

DSC2 involved in several pathways and played different roles in them. We selected most pathways DSC2 participated on our site, such as Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with DSC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arrhythmogenic right ventricular cardiomyopathyDMD;CTNNA1;CTNNA2;DES;DSG2;DSP;DSC2;DAG1;JUP
Arrhythmogenic right ventricular cardiomyopathy (ARVC)LAMA2;ACTN1;ITGB8;DES;CACNA2D3;ITGA10;CTNNA3;DSG2;ACTN2

DSC2 has several biochemical functions, for example, calcium ion binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSC2 itself. We selected most functions DSC2 had, and list some proteins which have the same functions with DSC2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCELSR1;EFEMP2B;PCDHB2;PLCD4;ANXA7;CDH12;MYL9B;S100Z;MYL12B
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communicationDSP;PKP2;CTNNA3;JUP;DSC2;DSG2
protein bindingCTDP1;S100P;GLDN;FOXK1;NTN4;ETF1;ZFYVE1;CDC37L1;PDLIM7

DSC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DSC2.

DSG2; GABARAPL1

Saruta, H; Ishii, N; et al. Two Cases of Pemphigus Vegetans With IgG Anti-Desmocollin 3 Antibodies. JAMA DERMATOLOGY 149:1209-1213(2013).
Arai, R; Okuda, H; et al. IgA pemphigus with non-pustular erythematous lesions and IgA antibodies to desmocollins 1 and 2. EUROPEAN JOURNAL OF DERMATOLOGY 23:362-365(2013).
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